Search Results - "Jiang, Wenxia"

PAXX promotes KU accumulation at DNA breaks and is essential for end-joining in XLF-deficient mice by Liu, Xiangyu, Shao, Zhengping, Jiang, Wenxia, Lee, Brian J., Zha, Shan

“…Non-homologous end-joining (NHEJ) is the most prominent DNA double strand break (DSB) repair pathway in mammalian cells. PAXX is the newest NHEJ factor, which…”
Get full text

Regulation of the DNA Damage Response by DNA-PKcs Inhibitory Phosphorylation of ATM by Zhou, Yi, Lee, Ji-Hoon, Jiang, Wenxia, Crowe, Jennie L., Zha, Shan, Paull, Tanya T.

“…Ataxia-telangiectasia mutated (ATM) regulates the DNA damage response as well as DNA double-strand break repair through homologous recombination. Here we show…”
Get full text

Alteration of Gut Microbiome and Correlated Lipid Metabolism in Post-Stroke Depression by Jiang, Wenxia, Gong, Lei, Liu, Fang, Ren, Yikun, Mu, Jun

“…The pathogenesis of post-stroke depression (PSD) remains largely unknown. There is growing evidence indicating that gut microbiota participates in the…”
Get full text

Screening of Immune-related lncRNAs in Lung Adenocarcinoma and Establishing a Survival Prognostic Risk Prediction Model by Jiang, Wenxia, Zhu, Xuyou, Bo, Jiaqi, Ma, Jun

“…This study aimed to improve lung adenocarcinoma (LUAD) prognosis prediction based on a signature of immune-related long non-coding RNAs (lncRNAs). LUAD samples…”
Get more information

Spata2 Knockdown Exacerbates Brain Inflammation via NF-κB/P38MAPK Signaling and NLRP3 Inflammasome Activation in Cerebral Ischemia/Reperfusion Rats by Ren, Yikun, Jiang, Jin, Jiang, Wenxia, Zhou, Xueling, Lu, Wenhao, Wang, Jingwen, Luo, Yong

“…Brain inflammation induced by ischemic stroke is an important cause of secondary brain injury. The nuclear factor kappa B (NF-κB), mitogen-activated protein…”
Get full text

An expressway traffic congestion measurement under the influence of service areas by Liao, Lyuchao, Li, Zhengrong, Lai, Shukun, Jiang, Wenxia, Zou, Fumin, Yu, Xiang, Xu, Zhiyu

“…Identifying traffic congestion accurately is crucial for improving the expressway service level. Because the distributions of microscopic traffic quantities…”
Get full text

Differential Phosphorylation of DNA-PKcs Regulates the Interplay between End-Processing and End-Ligation during Nonhomologous End-Joining by Jiang, Wenxia, Crowe, Jennifer L., Liu, Xiangyu, Nakajima, Satoshi, Wang, Yunyue, Li, Chen, Lee, Brian J., Dubois, Richard L., Liu, Chao, Yu, Xiaochun, Lan, Li, Zha, Shan

“…Nonhomologous end-joining (NHEJ) is a major DNA double-strand break repair pathway that is conserved in eukaryotes. In vertebrates, NHEJ further acquires…”
Get full text

The BRCT Domains of the BRCA1 and BARD1 Tumor Suppressors Differentially Regulate Homology-Directed Repair and Stalled Fork Protection by Billing, David, Horiguchi, Michiko, Wu-Baer, Foon, Taglialatela, Angelo, Leuzzi, Giuseppe, Nanez, Silvia Alvarez, Jiang, Wenxia, Zha, Shan, Szabolcs, Matthias, Lin, Chyuan-Sheng, Ciccia, Alberto, Baer, Richard

“…The BRCA1 tumor suppressor preserves genome integrity through both homology-directed repair (HDR) and stalled fork protection (SFP). In vivo, BRCA1 exists as a…”
Get full text

Interactome analysis identifies a new paralogue of XRCC4 in non-homologous end joining DNA repair pathway by Xing, Mengtan, Yang, Mingrui, Huo, Wei, Feng, Feng, Wei, Leizhen, Jiang, Wenxia, Ning, Shaokai, Yan, Zhenxin, Li, Wen, Wang, Qingsong, Hou, Mei, Dong, Chunxia, Guo, Rong, Gao, Ge, Ji, Jianguo, Zha, Shan, Lan, Li, Liang, Huanhuan, Xu, Dongyi

“…Non-homologous end joining (NHEJ) is a major pathway to repair DNA double-strand breaks (DSBs), which can display different types of broken ends. However, it…”
Get full text

Ipsilateral immunization after a prior SARS-CoV-2 mRNA vaccination elicits superior B cell responses compared to contralateral immunization by Jiang, Wenxia, Maldeney, Alexander R., Yuan, Xue, Richer, Martin J., Renshaw, Scott E., Luo, Wei

“…mRNA vaccines have proven to be pivotal in the fight against COVID-19. A recommended booster, given 3 to 4 weeks post the initial vaccination, can…”
Get full text

ATR kinase supports normal proliferation in the early S phase by preventing replication resource exhaustion by Menolfi, Demis, Lee, Brian J., Zhang, Hanwen, Jiang, Wenxia, Bowen, Nicole E., Wang, Yunyue, Zhao, Junfei, Holmes, Antony, Gershik, Steven, Rabadan, Raul, Kim, Baek, Zha, Shan

“…The ATR kinase, which coordinates cellular responses to DNA replication stress, is also essential for the proliferation of normal unstressed cells. Although…”
Get full text

Kinase-dead ATR differs from ATR loss by limiting the dynamic exchange of ATR and RPA by Menolfi, Demis, Jiang, Wenxia, Lee, Brian J., Moiseeva, Tatiana, Shao, Zhengping, Estes, Verna, Frattini, Mark G., Bakkenist, Christopher J., Zha, Shan

“…ATR kinase is activated by RPA-coated single-stranded DNA (ssDNA) to orchestrate DNA damage responses. Here we show that ATR inhibition differs from ATR loss…”
Get full text

Stem cells and vascular dementia: from basic science to the clinic by Jiang, Wenxia, Gong, Lei, Liu, Fang, Mu, Jun

“…Vascular dementia (VD) is the second most common cause of dementia following Alzheimer’s disease (AD). The major symptoms of VD including memory loss, language…”
Get full text

Hsa-miR-217 Inhibits the Proliferation, Migration and Invasion in Non-small-cell Lung Cancer Cells Via Targeting SIRT1 and p53/KAI1 Signaling by Jiang, Wenxia, Hou, Likun, Wei, Juan, Du, Yifeng, Zhao, Yan, Deng, Xue, Lin, Xiangdong

“…Brain metastasis is a major cause for cancer death in patients with lung cancer. Sirtuin 1 (SIRT1) and hsa-miR-217 has been identified to mediate the…”
Get full text

Kinase-dead ATM protein causes genomic instability and early embryonic lethality in mice by Yamamoto, Kenta, Wang, Yunyue, Jiang, Wenxia, Liu, Xiangyu, Dubois, Richard L, Lin, Chyuan-Sheng, Ludwig, Thomas, Bakkenist, Christopher J, Zha, Shan

“…Ataxia telangiectasia (A-T) mutated (ATM) kinase orchestrates deoxyribonucleic acid (DNA) damage responses by phosphorylating numerous substrates implicated in…”
Get full text

Kinase-dead ATM protein is highly oncogenic and can be preferentially targeted by Topo-isomerase I inhibitors by Yamamoto, Kenta, Wang, Jiguang, Sprinzen, Lisa, Xu, Jun, Haddock, Christopher J, Li, Chen, Lee, Brian J, Loredan, Denis G, Jiang, Wenxia, Vindigni, Alessandro, Wang, Dong, Rabadan, Raul, Zha, Shan

“…Missense mutations in ATM kinase, a master regulator of DNA damage responses, are found in many cancers, but their impact on ATM function and implications for…”
Get full text

Whole-Genome Sequencing and Analysis of the White-Rot Fungus Ceriporia lacerata Reveals Its Phylogenetic Status and the Genetic Basis of Lignocellulose Degradation and Terpenoid Synthesis by Mao, Zhitao, Yang, Ping, Liu, Huanhuan, Mao, Yufeng, Lei, Yu, Hou, Dongwei, Ma, Hongwu, Liao, Xiaoping, Jiang, Wenxia

“…is an endophytic white-rot fungus that has lignocellulolytic and terpenoid-biosynthetic abilities. However, little is known about the genomic architecture of…”
Get full text

Overlapping functions between XLF repair protein and 53BP1 DNA damage response factor in end joining and lymphocyte development by Liu, Xiangyu, Jiang, Wenxia, Dubois, Richard L, Yamamoto, Kenta, Wolner, Zachary, Zha, Shan

“…Nonhomologous end joining (NHEJ), a major pathway of DNA double-strand break (DSB) repair, is required during lymphocyte development to resolve the programmed…”
Get full text

Misidentification of Acute Psychiatric Symptoms in the Emergency Room: Clinical Experience in China by Liu, Fang, Chen, Jianjun, Du, Yang, Jiang, Wenxia, Gong, Lei, Mu, Jun

“…Patients who come to the emergency department because of acute psychiatric symptoms are often not admitted to the correct department timely. The purpose of…”
Get full text

Ataxia telangiectasia-mutated protein and DNA-dependent protein kinase have complementary V(D)J recombination functions by Zha, Shan, Jiang, Wenxia, Fujiwara, Yuko, Patel, Harin, Goff, Peter H, Brush, James W, Dubois, Richard L, Alt, Frederick W

“…Antigen receptor variable region exons are assembled during lymphocyte development from variable (V), diversity (D), and joining (J) gene segments. Each…”
Get full text