Search Results - "Jiang, Shi Hu"

nNOS‐CAPON blockers produce anxiolytic effects by promoting synaptogenesis in chronic stress‐induced animal models of anxiety by Zhu, Li‐Juan, Shi, Hu‐Jiang, Chang, Lei, Zhang, Cheng cheng, Si, Meng, Li, Na, Zhu, Dong‐Ya

“…Background and Purpose Anxiety disorder is a common mental health disorder. However, there are few safe and fast‐acting anxiolytic drugs available that can…”
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Hippocampal nuclear factor kappa B accounts for stress‐induced anxiety behaviors via enhancing neuronal nitric oxide synthase (nNOS)‐carboxy‐terminal PDZ ligand of nNOS‐Dexras1 coupling by Zhu, Li‐Juan, Ni, Huan‐Yu, Chen, Rong, Chang, Lei, Shi, Hu‐Jiang, Qiu, Dan, Zhang, Zhan, Wu, Dan‐Lian, Jiang, Zhao‐Chun, Xin, Hong‐Liang, Zhou, Qi‐Gang, Zhu, Dong‐Ya

“…Anxiety disorders are associated with a high social burden worldwide. Recently, increasing evidence suggests that nuclear factor kappa B (NF‐κB) has…”
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Requirement of hippocampal DG nNOS-CAPON dissociation for the anxiolytic and antidepressant effects of fluoxetine by Shi, Hu-Jiang, Wu, Dan-Lian, Chen, Rong, Li, Na, Zhu, Li-Juan

“…Adult hippocampal neurogenesis and synaptic plasticity are necessary for the behavioral response to the selective serotonin reuptake inhibitor (SSRI)…”
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Functional p53 is required for triptolide-induced apoptosis and AP-1 and nuclear factor-κB activation in gastric cancer cells by Jiang, Xiao-Hua, Wong, Benjamin Chun-Yu, Lin, Marie Chia-Mi, Zhu, Geng-Hui, Kung, Hsiang-Fu, Jiang, Shi-Hu, Yang, Dan, Lam, Shiu-Kum

“…Triptolide, a major component in the extract of Chinese herbal plant Tripterygium wilfordii Hook f (TWHf), has potential anti-neoplastic effect. In the present…”
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Restoration of XAF1 expression induces apoptosis and inhibits tumor growth in gastric cancer by Tu, Shui Ping, Liston, Peter, Cui, Jian Tao, Lin, Marie C.M., Jiang, Xiao Hua, Yang, Yi, Gu, Qing, Jiang, Shi Hu, Lum, Ching Tung, Kung, Hsiang Fu, Korneluk, Robert G, Wong, Benjamin Chun‐Yu

“…XAF1 (XIAP‐associated factor 1) is a novel XIAP binding protein that can antagonize XIAP and sensitize cells to other cell death triggers. Our previous results…”
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Systemic administration of ZLc-002 exerts anxiolytic-like effects by dissociation of nNOS from CAPON in adult mice by Zhu, Li-Juan, Chang, Lei, Shi, Hu-Jiang, Li, Na

“…Anxiety is recognized as primary clinical phenotype of psychiatric disorders. However, many patients with anxiety have not yet received effective treatment…”
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Arsenic trioxide induces apoptosis in human gastric cancer cells through up‐regulation of P53 and activation of caspase‐3 by Jiang, Xiao‐Hua, Chun‐Yu Wong, Benjamin, Yuen, Siu‐Tsan, Jiang, Shi‐Hu, Cho, Chi‐Hin, Lai, Kam‐Chuen, Lin, Marie C.M., Kung, Hsiang‐Fu, Lam, Shiu‐Kum

“…Arsenic trioxide (As2O3) can induce clinical remission in patients suffering from acute promyelocytic leukemia, through induction of apoptosis and activation…”
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Novel target for induction of apoptosis by cyclo-oxygenase-2 inhibitor SC-236 through a protein kinase C-β1-dependent pathway by JIANG, Xiao-Hua, LAM, Shiu-Kum, LIN, Marie C. M, JIANG, Shi-Hu, KUNG, Hsiang-Fu, SLOSBERG, Eric D, JAE WON SOH, WEINSTEIN, I. Bernard, WONG, Benjamin Chun-Yu

“…Nonsteroidal anti-inflammatory drugs (NSAIDs) reduce the risk of gastrointestinal cancers. Recently, a similar protective effect has been demonstrated by the…”
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Involvement of 5-HT1A receptor-mediated histone acetylation in the regulation of depression by Zhu, Li-Juan, Sun, Yan-Qiu, Wang, Shuang, Shi, Hu-Jiang, Li, Na

“…Depression is one of the most common and disabling mental disorders. There is growing evidence that 5-HT1A receptor is involved in the regulation of…”
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Hippocampus: Molecular, Cellular, and Circuit Features in Anxiety by Shi, Hu-Jiang, Wang, Shuang, Wang, Xin-Ping, Zhang, Rui-Xin, Zhu, Li-Juan

“…Anxiety disorders are currently a major psychiatric and social problem, the mechanisms of which have been only partially elucidated. The hippocampus serves as…”
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Suppression of RelA/p65 nuclear translocation independent of IκB-α degradation by cyclooxygenase-2 inhibitor in gastric cancer by CHUN YU WONG, Benjamin, XIAO HUA JIANG, XIAO MING FAN, CHIA MI LIN, Marie, SHI HU JIANG, SHIU KUM LAM, HSIANG FU KUNG

“…Selective cyclooxygenase-2 (COX-2) inhibitors are promising anti-inflammatory drugs with potential antitumor activities. The nuclear factor-kappa B (NF-κB)…”
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Correlation Between the Single-Site CpG Methylation and Expression Silencing of the XAF1 Gene in Human Gastric and Colon Cancers by Zou, Bing, Chim, Chor Sang, Zeng, Hui, Leung, Suet Yi, Yang, Yi, Tu, Shui Ping, Lin, Marie C.M., Wang, Jide, He, Hua, Jiang, Shi Hu, Sun, Yun Wei, Yu, Li Fen, Yuen, Siu Tsan, Kung, Hsiang Fu, Wong, Benjamin C.Y.

“…Background & Aims: X-linked inhibitor of apoptosis protein (XIAP)-associated factor 1 (XAF1) antagonizes the anti-caspase activity of XIAP. XAF1 messenger RNA…”
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Antisense Targeting Protein Kinase C α and β1 Inhibits Gastric Carcinogenesis by Jiang, Xiao-Hua, Tu, Shui-Ping, Cui, Jian-Tao, Lin, Marie C. M., Xia, Harry H. X., Wong, Wai Man, Chan, Annie On-On, Yuen, Man Fung, Jiang, Shi-Hu, Lam, Shiu-Kum, Kung, Hsiang-Fu, Soh, Jae Won, Weinstein, I. Bernard, Wong, Benjamin Chun-Yu

“…Abstract Protein kinase C (PKC) family, which functions through serine/threonine kinase activity, is involved in signal transduction pathways necessary for…”
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Cyclooxygenase-2 inhibitor (SC-236) suppresses activator protein-1 through c-Jun NH2-terminal kinase by Wong, Benjamin Chun-Yu, Jiang, Xiao Hua, Lin, Marie C m, Tu, Shui Ping, Cui, Jian Tao, Jiang, Shi Hu, Wong, Wai Man, Yuen, Man Fung, Lam, Shiu Kum, Kung, Hsiang Fu

“…Aspirin exerts antitumor effect partly through blocking tumor promoter-induced activator protein-1 (AP-1) activation. The aim of this study is to determine how…”
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Tumor suppressor XIAP‐Associated factor 1 (XAF1) cooperates with tumor necrosis factor‐related apoptosis‐inducing ligand to suppress colon cancer growth and trigger tumor regression by Tu, Shui Ping, Sun, Yun Wei, Cui, Jian Tao, Zou, Bing, Lin, Marie C. M., Gu, Qing, Jiang, Shi Hu, Kung, Hsiang Fu, Korneluk, Robert G., Wong, Benjamin C. Y.

“…BACKGROUND: XIAP‐associated factor 1 (XAF1) antagonizes the anticaspase activity of XIAP (X‐linked inhibitor of apoptosis) and functions as a tumor suppressor…”
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Suppression of survivin expression inhibits in vivo tumorigenicity and angiogenesis in gastric cancer by SHUI PING TU, XIAO HUA JIANG, CHAN, Annie On-On, MAN FUNG YUEN, SHIU KUM LAM, HSIANG FU KUNG, WONG, Benjamin Chun-Yu, LIN, Marie C. M, JIAN TAO CUI, YI YANG, CHING TUNG LUM, BING ZOU, YAN BO ZHU, SHI HU JIANG, WAI MAN WONG

“…Survivin plays an important role in cancer development. We aim to show here that suppression of survivin expression or function by antisense and…”
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The Role of Vesicle Release and Synaptic Transmission in Depression by Zhang, Cheng-Cheng, Zhu, Li-Xia, Shi, Hu-Jiang, Zhu, Li-Juan

“…•Abnormal synaptic plasticity and synaptic homeostasis imbalance in depression.•Aberrant presynaptic SNARE-mediated vesicle release affects synaptic…”
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Hippocampal HDAC5-mediated histone acetylation underlies stress susceptibility in mice exposed to chronic social defeat stress by Li, Na, Liu, Ting, Wang, Yu-Ye, Xu, Tong, Shi, Hu-Jiang, Chang, Lei, Zhu, Li-Juan

“…•Hippocampal HDAC5 regulates histone H4 acetylation and stress susceptibility.•Knockdown of the HDAC5 reverses CSDS-induced depression susceptibility.•HDAC5…”
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Involvement of 5-HT1A receptor-mediated histone acetylation in the regulation of depression by Zhu, Li-Juan, Sun, Yan-Qiu, Wang, Shuang, Shi, Hu-Jiang, Li, Na

“…Depression is one of the most common and disabling mental disorders. There is growing evidence that 5-HT1A receptor is involved in the regulation of…”
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Hippocampal excitation-inhibition balance underlies the 5-HT2C receptor in modulating depressive behaviours by Shi, Hu-Jiang, Xue, Yi-Ren, Shao, Hua, Wei, Cheng, Liu, Ting, He, Jie, Yang, Yu-Hao, Wang, Hong-Mei, Li, Na, Ren, Si-Qiang, Chang, Lei, Wang, Zhen, Zhu, Li-Juan

“…The implication of 5-hydroxytryptamine 2C receptor (5-HT2CR) in depression is a topic of debate, and the underlying mechanisms remain largely unclear. We now…”
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