Search Results - "Jiang, Mengshi"

Targeting photodynamic and photothermal therapy to the endoplasmic reticulum enhances immunogenic cancer cell death by Li, Wei, Yang, Jie, Luo, Lihua, Jiang, Mengshi, Qin, Bing, Yin, Hang, Zhu, Chunqi, Yuan, Xiaoling, Zhang, Junlei, Luo, Zhenyu, Du, Yongzhong, Li, Qingpo, Lou, Yan, Qiu, Yunqing, You, Jian

“…Immunogenic cell death (ICD)-associated immunogenicity can be evoked through reactive oxygen species (ROS) produced via endoplasmic reticulum (ER) stress. In…”
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Extremely Effective Chemoradiotherapy by Inducing Immunogenic Cell Death and Radio-Triggered Drug Release under Hypoxia Alleviation by Zhu, Chunqi, Guo, Xiaomeng, Luo, Lihua, Wu, Zhe, Luo, Zhenyu, Jiang, Mengshi, Zhang, Junlei, Qin, Bing, Shi, Yingying, Lou, Yan, Qiu, Yunqing, You, Jian

“…Local hypoxia in solid malignancies often results in resistance to radiotherapy (RT) and chemotherapy (CT), which may be one of the main reasons for their…”
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Regulating immune memory and reversing tumor thermotolerance through a step-by-step starving-photothermal therapy by Luo, Lihua, Qin, Bing, Jiang, Mengshi, Xie, Lin, Luo, Zhenyu, Guo, Xuemeng, Zhang, Junlei, Li, Xiang, Zhu, Chunqi, Du, Yongzhong, Peng, Ling, You, Jian

“…Photothermal therapy (PTT) is a highly effective treatment for solid tumors and can induce long-term immune memory worked like an in situ vaccine…”
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Virus-like Nonvirus Cationic Liposome for Efficient Gene Delivery via Endoplasmic Reticulum Pathway by Yuan, Xiaoling, Qin, Bing, Yin, Hang, Shi, Yingying, Jiang, Mengshi, Luo, Lihua, Luo, Zhenyu, Zhang, Junlei, Li, Xiang, Zhu, Chunqi, Du, Yongzhong, You, Jian

“…Gene vectors play a critical role in gene therapy. To achieve efficient transfection, we developed a novel nonvirus cationic liposome (Lipo-Par), which was…”
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Oxygen nanocarrier broke the hypoxia trap of solid tumors and rescued transfection efficiency for gene therapy by Qin, Bing, Jiang, Mengshi, Li, Xiang, Shi, Yingying, Zhang, Junlei, Luo, Zhenyu, Luo, Lihua, Lu, Yichao, Liu, Xu, Wang, Sijie, Du, Yongzhong, Qiu, Yunqing, Lou, Yan, You, Jian

“…Gene therapy shows great promise for a broad array of diseases. However, we found that hypoxic tumor microenvironment (TME) exerted significant inhibitory…”
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Appropriate Delivery of the CRISPR/Cas9 System through the Nonlysosomal Route: Application for Therapeutic Gene Editing by Yin, Hang, Yuan, Xiaoling, Luo, Lihua, Lu, Yichao, Qin, Bing, Zhang, Junlei, Shi, Yingying, Zhu, Chunqi, Yang, Jie, Li, Xiang, Jiang, Mengshi, Luo, Zhenyu, Shan, Xinyu, Chen, Dawei, You, Jian

“…The development of gene delivery has attracted increasing attention, especially when the introduction and application of the CRISPR/Cas9 gene editing system…”
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Dual-binding nanoparticles improve the killing effect of T cells on solid tumor by Luo, Zhenyu, Luo, Lihua, Lu, Yichao, Zhu, Chunqi, Qin, Bing, Jiang, Mengshi, Li, Xiang, Shi, Yingying, Zhang, Junlei, Liu, Yu, Shan, Xinyu, Yin, Hang, Guan, Guannan, Du, Yongzhong, Cheng, Ningtao, You, Jian

“…Adoptive cell therapy (ACT) was one of the most promising anti-tumor modalities that has been confirmed to be especially effective in treating hematological…”
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A cabazitaxel liposome for increased solubility, enhanced antitumor effect and reduced systemic toxicity by Yin, Xiaoyi, Luo, Lihua, Li, Wei, Yang, Jie, Zhu, Chunqi, Jiang, Mengshi, qin, Bing, Yuan, Xiaoling, Yin, Hang, Lu, Yichao, Du, Yongzhong, Chen, Dawei, You, Jian

“…The potential side effects of cabazitaxel (CBZ) in the field of cancer treatment have become a great limitation to its further clinical application. Liposomal…”
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Ultrahigh-Speed 3D DNA Walker with Dual Self-Protected DNAzymes for Ultrasensitive Fluorescence Detection and Intracellular Imaging of microRNA by Jiang, Mengshi, Zhou, Jie, Chai, Yaqin, Yuan, Ruo

“…Herein, a dual self-protected DNAzyme-based 3D DNA walker (dSPD walker), composed of activated dual self-protected walking particles (ac-dSPWPs) and track…”
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ER-Targeting PDT Converts Tumors into In Situ Therapeutic Tumor Vaccines by Liu, Xu, Liu, Yu, Li, Xiang, Huang, Jiaxin, Guo, Xuemeng, Zhang, Junlei, Luo, Zhenyu, Shi, Yingying, Jiang, Mengshi, Qin, Bing, Du, Yongzhong, Luo, Lihua, You, Jian

“…A therapeutic tumor vaccine is a promising approach to cancer treatment. One of its strategies is to treat patient-derived tumor cells in vitro and then…”
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Laser Immunotherapy in Combination with Perdurable PD‑1 Blocking for the Treatment of Metastatic Tumors by Luo, Lihua, Zhu, Chunqi, Yin, Hang, Jiang, Mengshi, Zhang, Junlei, Qin, Bing, Luo, Zhenyu, Yuan, Xiaoling, Yang, Jie, Li, Wei, Du, Yongzhong, You, Jian

“…A convenient and feasible therapeutic strategy for malignant and metastatic tumors was constructed here by combining photothermal ablation (PTA)-based laser…”
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Hypoxic tumor therapy by hemoglobin-mediated drug delivery and reversal of hypoxia-induced chemoresistance by Yang, Jie, Li, Wei, Luo, Lihua, Jiang, Mengshi, Zhu, Chunqi, Qin, Bing, Yin, Hang, Yuan, Xiaoling, Yin, Xiaoyi, Zhang, Junlei, Luo, Zhenyu, Du, Yongzhong, You, Jian

“…Chemotherapy has become a critical treatment for many cancer types. However, its efficacy is hindered by chemoresistance and limited drug accumulation induced…”
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The Acid-Stimulated Self-Assembled DNA Nanonetwork for Sensitive Detection and Living Cancer Cell Imaging of MicroRNA-221 by Han, Yichen, Jiang, Mengshi, Zhou, Jie, Lei, Hongmin, Yuan, Ruo, Chai, Yaqin

“…Herein, a novel functional DNA structure, acid-stimulated self-assembly DNA nanonetwork (ASDN), was proposed for miRNA-221 sensitive detection and…”
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Dual Inhibition of Endoplasmic Reticulum Stress and Oxidation Stress Manipulates the Polarization of Macrophages under Hypoxia to Sensitize Immunotherapy by Jiang, Mengshi, Li, Xiang, Zhang, Junlei, Lu, Yichao, Shi, Yingying, Zhu, Chunqi, Liu, Yu, Qin, Bing, Luo, Zhenyu, Du, Yongzhong, Luo, Lihua, Peng, Ling, You, Jian

“…M2-tumor associated macrophages (TAMs) play an important role in tumor genesis, progression, and metastasis, and repolarizing M2-TAMs to immune-promoting M1…”
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Sustained release of anti-PD-1 peptide for perdurable immunotherapy together with photothermal ablation against primary and distant tumors by Luo, Lihua, Yang, Jie, Zhu, Chunqi, Jiang, Mengshi, Guo, Xiaomeng, Li, Wei, Yin, Xiaoyi, Yin, Hang, Qin, Bin, Yuan, Xiaoling, Li, Qingpo, Du, Yongzhong, You, Jian

“…Immune checkpoint PD-1/PD-L1 blockade has emerged as a successful immunotherapy strategy for treating several types of malignant tumors. A constant and proper…”
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Neutrophil hitchhiking for drug delivery to the bone marrow by Luo, Zhenyu, Lu, Yichao, Shi, Yingying, Jiang, Mengshi, Shan, Xinyu, Li, Xiang, Zhang, Junlei, Qin, Bing, Liu, Xu, Guo, Xuemeng, Huang, Jiaxin, Liu, Yu, Wang, Sijie, Li, Qingpo, Luo, Lihua, You, Jian

“…Pharmaceuticals have been developed for the treatment of a wide range of bone diseases and disorders, but suffer from problematic delivery to the bone marrow…”
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Endoplasmic reticulum-targeted inhibition of CYP2E1 with vitamin E nanoemulsions alleviates hepatocyte oxidative stress and reverses alcoholic liver disease by Shi, Yingying, Liu, Yu, Wang, Sijie, Huang, Jiaxin, Luo, Zhenyu, Jiang, Mengshi, Lu, Yichao, Lin, Qing, Liu, Huihui, Cheng, Ningtao, You, Jian

“…Alcoholic liver disease (ALD) is a global healthcare problem and socioeconomic issue that is primarily driven by chronic and/or excessive alcohol consumption…”
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Perdurable PD-1 blockage awakes anti-tumor immunity suppressed by precise chemotherapy by Jiang, Mengshi, Li, Wei, Zhu, Chunqi, Li, Xiang, Zhang, Junlei, Luo, Zhenyu, Qin, Bing, Du, Yongzhong, Luo, Lihua, You, Jian

“…The application of nanocarriers as drug delivery system for chemotherapeutic drugs has become a research hotspot in cancer treatment. Chemotherapy with high…”
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Arginine Supplementation Targeting Tumor-Killing Immune Cells Reconstructs the Tumor Microenvironment and Enhances the Antitumor Immune Response by Zhang, Junlei, Wang, Sijie, Guo, Xuemeng, Lu, Yichao, Liu, Xu, Jiang, Mengshi, Li, Xiang, Qin, Bing, Luo, Zhenyu, Liu, Huihui, Li, Qingpo, Du, Yong-Zhong, Luo, Lihua, You, Jian

“…The tumor microenvironment (TME) is characterized by several immunosuppressive factors, of which weak acidity and l-arginine (l-arg) deficiency are two common…”
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A clinically acceptable strategy for sensitizing anti-PD-1 treatment by hypoxia relief by Jiang, Mengshi, Qin, Bing, Luo, Lihua, Li, Xiang, Shi, Yingying, Zhang, Junlei, Luo, Zhenyu, Zhu, Chunqi, Guan, Guannan, Du, Yongzhong, You, Jian

“…The hypoxic tumor microenvironment (TME) hinders the effectiveness of immunotherapy. Alleviating tumor hypoxia to improve the efficacy of immune checkpoint…”
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