Search Results - "Jiang, Hualiang"

Cryo-EM structure determination captures new chemical modification of protein by Jiang, Hualiang

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Identification of pyrogallol as a warhead in design of covalent inhibitors for the SARS-CoV-2 3CL protease by Su, Haixia, Yao, Sheng, Zhao, Wenfeng, Zhang, Yumin, Liu, Jia, Shao, Qiang, Wang, Qingxing, Li, Minjun, Xie, Hang, Shang, Weijuan, Ke, Changqiang, Feng, Lu, Jiang, Xiangrui, Shen, Jingshan, Xiao, Gengfu, Jiang, Hualiang, Zhang, Leike, Ye, Yang, Xu, Yechun

“…The ongoing pandemic of coronavirus disease 2019 (COVID-19) caused by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) urgently needs an effective…”
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Structural basis for inhibition of the SARS-CoV-2 RNA polymerase by suramin by Yin, Wanchao, Luan, Xiaodong, Li, Zhihai, Zhou, Ziwei, Wang, Qingxing, Gao, Minqi, Wang, Xiaoxi, Zhou, Fulai, Shi, Jingjing, You, Erli, Liu, Mingliang, Wang, Qingxia, Jiang, Yi, Jiang, Hualiang, Xiao, Gengfu, Zhang, Leike, Yu, Xuekui, Zhang, Shuyang, Eric Xu, H.

“…The COVID-19 pandemic caused by nonstop infections of SARS-CoV-2 has continued to ravage many countries worldwide. Here we report that suramin, a 100-year-old…”
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Rhodium(III)-Catalyzed Site-Selective C–H Alkylation and Arylation of Pyridones Using Organoboron Reagents by Peng, Panfeng, Wang, Jiang, Jiang, Hualiang, Liu, Hong

“…In this study we developed a method for the pyridine-directed, rhodium-catalyzed, site-selective C–H alkylation and arylation of pyridones using commercially…”
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Structural basis for inhibition of the RNA-dependent RNA polymerase from SARS-CoV-2 by remdesivir by Yin, Wanchao, Mao, Chunyou, Luan, Xiaodong, Shen, Dan-Dan, Shen, Qingya, Su, Haixia, Wang, Xiaoxi, Zhou, Fulai, Zhao, Wenfeng, Gao, Minqi, Chang, Shenghai, Xie, Yuan-Chao, Tian, Guanghui, Jiang, He-Wei, Tao, Sheng-Ce, Shen, Jingshan, Jiang, Yi, Jiang, Hualiang, Xu, Yechun, Zhang, Shuyang, Zhang, Yan, Xu, H Eric

“…The pandemic of coronavirus disease 2019 (COVID-19), caused by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), has become a global crisis…”
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Structure-based design of antiviral drug candidates targeting the SARS-CoV-2 main protease by Dai, Wenhao, Zhang, Bing, Jiang, Xia-Ming, Su, Haixia, Li, Jian, Zhao, Yao, Xie, Xiong, Jin, Zhenming, Peng, Jingjing, Liu, Fengjiang, Li, Chunpu, Li, You, Bai, Fang, Wang, Haofeng, Cheng, Xi, Cen, Xiaobo, Hu, Shulei, Yang, Xiuna, Wang, Jiang, Liu, Xiang, Xiao, Gengfu, Jiang, Hualiang, Rao, Zihe, Zhang, Lei-Ke, Xu, Yechun, Yang, Haitao, Liu, Hong

“…SARS-CoV-2 (severe acute respiratory syndrome coronavirus 2) is the etiological agent responsible for the global COVID-19 (coronavirus disease 2019) outbreak…”
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Full-length human GLP-1 receptor structure without orthosteric ligands by Wu, Fan, Yang, Linlin, Hang, Kaini, Laursen, Mette, Wu, Lijie, Han, Gye Won, Ren, Qiansheng, Roed, Nikolaj Kulahin, Lin, Guangyao, Hanson, Michael A., Jiang, Hualiang, Wang, Ming-Wei, Reedtz-Runge, Steffen, Song, Gaojie, Stevens, Raymond C.

“…Glucagon-like peptide-1 receptor (GLP-1R) is a class B G protein-coupled receptor that plays an important role in glucose homeostasis and treatment of type 2…”
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Potential treatment of COVID-19 by inhibitors of human dihydroorotate dehydrogenase by Xu, Yechun, Jiang, Hualiang

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Small-Molecule Targeting of Oncogenic FTO Demethylase in Acute Myeloid Leukemia by Huang, Yue, Su, Rui, Sheng, Yue, Dong, Lei, Dong, Ze, Xu, Hongjiao, Ni, Tengfeng, Zhang, Zijie Scott, Zhang, Tao, Li, Chenying, Han, Li, Zhu, Zhenyun, Lian, Fulin, Wei, Jiangbo, Deng, Qiangqiang, Wang, Yungui, Wunderlich, Mark, Gao, Zhiwei, Pan, Guoyu, Zhong, Dafang, Zhou, Hu, Zhang, Naixia, Gan, Jianhua, Jiang, Hualiang, Mulloy, James C., Qian, Zhijian, Chen, Jianjun, Yang, Cai-Guang

“…FTO, an mRNA N6-methyladenosine (m6A) demethylase, was reported to promote leukemogenesis. Using structure-based rational design, we have developed two…”
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Structural basis for allosteric, substrate-dependent stimulation of SIRT1 activity by resveratrol by Cao, Duanfang, Wang, Mingzhu, Qiu, Xiayang, Liu, Dongxiang, Jiang, Hualiang, Yang, Na, Xu, Rui-Ming

“…Sirtuins with an extended N-terminal domain (NTD), represented by yeast Sir2 and human SIRT1, harbor intrinsic mechanisms for regulation of their NAD-dependent…”
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Structural basis of leukotriene B4 receptor 1 activation by Wang, Na, He, Xinheng, Zhao, Jing, Jiang, Hualiang, Cheng, Xi, Xia, Yu, Eric Xu, H., He, Yuanzheng

“…Leukotriene B4 receptor 1 (BLT1) plays crucial roles in the acute inflammatory responses and is a valuable target for anti-inflammation treatment, however, the…”
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Crystal Structures of Membrane Transporter MmpL3, an Anti-TB Drug Target by Zhang, Bing, Li, Jun, Yang, Xiaolin, Wu, Lijie, Zhang, Jia, Yang, Yang, Zhao, Yao, Zhang, Lu, Yang, Xiuna, Yang, Xiaobao, Cheng, Xi, Liu, Zhijie, Jiang, Biao, Jiang, Hualiang, Guddat, Luke W., Yang, Haitao, Rao, Zihe

“…Despite intensive efforts to discover highly effective treatments to eradicate tuberculosis (TB), it remains as a major threat to global human health. For this…”
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SHAFTS: A Hybrid Approach for 3D Molecular Similarity Calculation. 1. Method and Assessment of Virtual Screening by Liu, Xiaofeng, Jiang, Hualiang, Li, Honglin

“…We developed a novel approach called SHAFTS (SHApe-FeaTure Similarity) for 3D molecular similarity calculation and ligand-based virtual screening. SHAFTS…”
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Low dose of hydroxychloroquine reduces fatality of critically ill patients with COVID-19 by Yu, Bo, Li, Chenze, Chen, Peng, Zhou, Ning, Wang, Luyun, Li, Jia, Jiang, Hualiang, Wang, Dao-Wen

“…Coronavirus disease 2019 (COVID-19) is a pandemic with no specific drugs and high fatality. The most urgent need is to find effective treatments. We sought to…”
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Design and development of an oral remdesivir derivative VV116 against SARS-CoV-2 by Xie, Yuanchao, Yin, Wanchao, Zhang, Yumin, Shang, Weijuan, Wang, Zhen, Luan, Xiaodong, Tian, Guanghui, Aisa, Haji A., Xu, Yechun, Xiao, Gengfu, Li, Jia, Jiang, Hualiang, Zhang, Shuyang, Zhang, Leike, Xu, H. Eric, Shen, Jingshan

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Structure and mechanism of the essential two-component signal-transduction system WalKR in Staphylococcus aureus by Ji, Quanjiang, Chen, Peter J., Qin, Guangrong, Deng, Xin, Hao, Ziyang, Wawrzak, Zdzislaw, Yeo, Won-Sik, Quang, Jenny Winjing, Cho, Hoonsik, Luo, Guan-Zheng, Weng, Xiaocheng, You, Qiancheng, Luan, Chi-Hao, Yang, Xiaojing, Bae, Taeok, Yu, Kunqian, Jiang, Hualiang, He, Chuan

“…Most low GC Gram-positive bacteria possess an essential walKR two-component system (TCS) for signal transduction involved in regulating cell wall homoeostasis…”
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Discovery of Highly Potent, Selective, and Orally Efficacious p300/CBP Histone Acetyltransferases Inhibitors by Yang, Yaxi, Zhang, Rukang, Li, Zhaojun, Mei, Lianghe, Wan, Shili, Ding, Hong, Chen, Zhifeng, Xing, Jing, Feng, Huijin, Han, Jie, Jiang, Hualiang, Zheng, Mingyue, Luo, Cheng, Zhou, Bing

“…p300 and CREB-binding protein (CBP) are ubiquitously expressed pleiotropic lysine acetyltransferases and play a key role as transcriptional co-activators that…”
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Discovery of the First-in-Class Agonist-Based SOS1 PROTACs Effective in Human Cancer Cells Harboring Various KRAS Mutations by Zhou, Chuan, Fan, Zisheng, Zhou, Zehui, Li, Yupeng, Cui, Rongrong, Liu, Chaoyi, Zhou, Guizhen, Diao, Xingxing, Jiang, Hualiang, Zheng, Mingyue, Zhang, Sulin, Xu, Tianfeng

“…Regulating SOS1 functions may result in targeted pan-KRAS therapies. Small-molecule SOS1 inhibitors showed promising anticancer potential, and the most…”
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Molecular basis for allosteric agonism and G protein subtype selectivity of galanin receptors by Duan, Jia, Shen, Dan-Dan, Zhao, Tingting, Guo, Shimeng, He, Xinheng, Yin, Wanchao, Xu, Peiyu, Ji, Yujie, Chen, Li-Nan, Liu, Jinyu, Zhang, Huibing, Liu, Qiufeng, Shi, Yi, Cheng, Xi, Jiang, Hualiang, Eric Xu, H., Zhang, Yan, Xie, Xin, Jiang, Yi

“…Peptide hormones and neuropeptides are complex signaling molecules that predominately function through G protein-coupled receptors (GPCRs). Two unanswered…”
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Two disparate ligand-binding sites in the human P2Y1 receptor by Zhang, Dandan, Gao, Zhan-Guo, Zhang, Kaihua, Kiselev, Evgeny, Crane, Steven, Wang, Jiang, Paoletta, Silvia, Yi, Cuiying, Ma, Limin, Zhang, Wenru, Han, Gye Won, Liu, Hong, Cherezov, Vadim, Katritch, Vsevolod, Jiang, Hualiang, Stevens, Raymond C., Jacobson, Kenneth A., Zhao, Qiang, Wu, Beili

“…In response to adenosine 5′-diphosphate, the P2Y 1 receptor (P2Y 1 R) facilitates platelet aggregation, and thus serves as an important antithrombotic drug…”
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