Search Results - "Jiang, Huailei"

The First Human Application of an F-18-Labeled Tryptophan Analog for PET Imaging of Cancer by Muzik, Otto, Shields, Anthony F., Barger, Geoffrey R., Jiang, Huailei, Chamiraju, Parthasarathi, Juhász, Csaba

“…Purpose Preclinical studies showed the tryptophan analog PET radiotracer 1-(2- 18 F-fluoroethyl)-L-tryptophan ( 18 F-FETrp) to accumulate in various tumors,…”
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Benzenediol-berberine hybrids: Multifunctional agents for Alzheimer’s disease by Jiang, Huailei, Wang, Xu, Huang, Ling, Luo, Zonghua, Su, Tao, Ding, Ke, Li, Xingshu

“…A series of hybrid molecules, by reacting berberine with benzenediol, melatonin, or ferulic acid, were designed and synthesized. These compounds were evaluated…”
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Enhanced noninvasive imaging of oncology models using the NIS reporter gene and bioluminescence imaging by Vandergaast, Rianna, Khongwichit, Sarawut, Jiang, Huailei, DeGrado, Timothy R., Peng, Kah-Whye, Smith, Duncan R., Russell, Stephen J., Suksanpaisan, Lukkana

“…Noninvasive bioluminescence imaging (BLI) of luciferase-expressing tumor cells has advanced pre-clinical evaluation of cancer therapies. Yet despite its…”
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First PET Imaging Studies With Zn-Zinc Citrate in Healthy Human Participants and Patients With Alzheimer Disease by Timothy R. DeGrado PhD, Bradley J. Kemp PhD, Mukesh K. Pandey PhD, Huailei Jiang PhD, Tina M. Gunderson MS, Logan R. Linscheid CNMT, Allison R. Woodwick CNMT, Daniel M. McConnell CNMT, Joel G. Fletcher MD, Geoffrey B. Johnson MD, PhD, Ronald C. Petersen MD, PhD, David S. Knopman MD, Val J. Lowe MD

“…Abnormalities in zinc homeostasis are indicated in many human diseases, including Alzheimer disease (AD). 63 Zn-zinc citrate was developed as a positron…”
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First PET Imaging Studies With 63Zn-Zinc Citrate in Healthy Human Participants and Patients With Alzheimer Disease by DeGrado, Timothy R., Kemp, Bradley J., Pandey, Mukesh K., Jiang, Huailei, Gunderson, Tina M., Linscheid, Logan R., Woodwick, Allison R., McConnell, Daniel M., Fletcher, Joel G., Johnson, Geoffrey B., Petersen, Ronald C., Knopman, David S., Lowe, Val J.

“…Abnormalities in zinc homeostasis are indicated in many human diseases, including Alzheimer disease (AD). 63Zn-zinc citrate was developed as a positron…”
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Dual-Isotope SPECT Imaging with NIS Reporter Gene and Duramycin to Visualize Tumor Susceptibility to Oncolytic Virus Infection by Zhang, Lianwen, Suksanpaisan, Lukkana, Jiang, Huailei, DeGrado, Timothy R., Russell, Stephen J., Zhao, Ming, Peng, Kah-Whye

“…Noninvasive dual-imaging methods that provide an early readout on tumor permissiveness to virus infection and tumor cell death could be valuable in optimizing…”
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Ex Vivo Cell Therapy by Ectopic Hepatocyte Transplantation Treats the Porcine Tyrosinemia Model of Acute Liver Failure by Nicolas, Clara T., Kaiser, Robert A., Hickey, Raymond D., Allen, Kari L., Du, Zeji, VanLith, Caitlin J., Guthman, Rebekah M., Amiot, Bruce, Suksanpaisan, Lukkana, Han, Bing, Francipane, Maria Giovanna, Cheikhi, Amin, Jiang, Huailei, Bansal, Aditya, Pandey, Mukesh K., Garg, Ishan, Lowe, Val, Bhagwate, Aditya, O’Brien, Daniel, Kocher, Jean-Pierre A., DeGrado, Timothy R., Nyberg, Scott L., Lagasse, Eric, Lillegard, Joseph B.

“…The effectiveness of cell-based therapies to treat liver failure is often limited by the diseased liver environment. Here, we provide preclinical proof of…”
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Safety, pharmacokinetics, metabolism and radiation dosimetry of 18F-tetrafluoroborate (18F-TFB) in healthy human subjects by Jiang, Huailei, Schmit, Nicholas R., Koenen, Alex R., Bansal, Aditya, Pandey, Mukesh K., Glynn, Robert B., Kemp, Bradley J., Delaney, Kera L., Dispenzieri, Angela, Bakkum-Gamez, Jamie N., Peng, Kah-Whye, Russell, Stephen J., Gunderson, Tina M., Lowe, Val J., DeGrado, Timothy R.

“…Background 18 F-Tetrafluoroborate ( 18 F-TFB) is a promising iodide analog for PET imaging of thyroid cancer and sodium/iodide symporter (NIS) reporter…”
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Analysis of [11C]Choline Using High Pressure Ion Chromatography System (HPIC) with Autosampler by Jiang, Huailei, Jain, Manoj, Cai, Hancheng

“…Objectives: Solid-phase extraction (SPE) based [11C]Choline synthesis simplifies the production process and eliminates the use of HPLC for the final…”
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[ 18 F]Tetrafluoroborate ([ 18 F]TFB) and its analogs for PET imaging of the sodium/iodide symporter by Jiang, Huailei, DeGrado, Timothy R

“…Sodium/iodide symporter (NIS)-mediated iodide uptake in thyroid follicular cells is the basis of clinical utilization of radioiodines. The cloning of the NIS…”
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Multitarget-Directed Benzylideneindanone Derivatives: Anti-β-Amyloid (Aβ) Aggregation, Antioxidant, Metal Chelation, and Monoamine Oxidase B (MAO-B) Inhibition Properties against Alzheimer’s Disease by Huang, Ling, Lu, Chuanjun, Sun, Yang, Mao, Fei, Luo, Zonghua, Su, Tao, Jiang, Huailei, Shan, Wenjun, Li, Xingshu

“…A novel series of benzylideneindanone derivatives were designed, synthesized, and evaluated as multitarget-directed ligands against Alzheimer’s disease. The in…”
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Fully Automated Radiosynthesis of 1-(2-[18F]Fluoroethyl)-L-Tryptophan ([18F]FETrp) by Jiang, Huailei, Guo, Yan, Cai, Hancheng, Viola, Nerissa, Shields, Anthony, Muzik, Otto, Juhasz, Csaba

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Automated radiosynthesis of [18F]FMPEP-d2 for cannabinoid receptor PET imaging by Jiang, Huailei, Guo, Yan, Muzik, Otto

“…The cannabinoid subtype 1 receptor (CB1R) is highly expressed in the central nervous system and abnormalities in regional CB1R density are associated with…”
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Synthesis and evaluation of nitroimidazole dimer for tumor hypoxia PETimaging by Jiang, Huailei, Bansal, Aditya, Sarkaria, Jann, DeGrado, Timothy

“…Objectives: Tumor hypoxia is a key hallmark in malignant cancers associated with tumor metastasis and resistance to radiotherapy. Identification of tumor…”
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Automated radiosynthesis of 1‐(2‐[18F]fluoroethyl)‐L‐tryptophan ([18F]FETrp) for positron emission tomography (PET) imaging of cancer in humans by Jiang, Huailei, Guo, Yan, Cai, Hancheng, Viola, Nerissa, Shields, Anthony Frank, Muzik, Otto, Juhasz, Csaba

“…The radiotracer 1‐(2‐[18F]fluoroethyl)‐L‐tryptophan (L‐[18F]FETrp or [18F]FETrp) is a substrate of indoleamine 2,3‐dioxygenase, the initial and key enzyme of…”
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Analysis of [11C]Choline and [13N]Ammonia using a single HPIC method by Jiang, Huailei, Fang, Ping, Jacobson, Mark S., Jain, Manoj K., Cai, Hancheng

“…A single HPIC method was developed and validated for the analysis of both [11C]Choline and [13N]Ammonia with the same setup. The HPIC system suitability tests…”
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Automated radiosynthesis of [ 11 C]CPPC for in-human PET imaging applications by Jiang, Huailei, Roy, Pritam, Guo, Yan, Muzik, Otto, Woodcock, Eric A

“…The macrophage colony-stimulating factor 1 receptor (CSF1R) is almost exclusively expressed in microglia, representing a biomarker target for imaging of…”
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HPLC-free and cassette-based nucleophilic production of [18F]FDOPA for clinical use by Jiang, Huailei, Jain, Manoj K, Cai, Hancheng

“…Radiotracer 3,4-dihydroxy-6-[ 18 F]fluoro-L-phenylalanine (L-6-[ 18 F]fluorodopa or [ 18 F]FDOPA) is widely used for PET imaging of dopamine metabolism in…”
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Radiation dosimetry of ^sup 18^F-Tetrafluoroborate (^sup 18^F-TFB) in healthy human subjects by Koenen, Alex, Schmit, Nicholas, Kemp, Brad, Jiang, Huailei, Delaney, Kera, Lowe, Val, Swanson, Tiffinee, DeGrado, Timothy

“…Objectives: The goal of this study was to study the biodistribution, metabolism and radiation dosimetry of the first human control studies using…”
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Curative ex vivo liver-directed gene therapy in a pig model of hereditary tyrosinemia type 1 by Hickey, Raymond D, Mao, Shennen A, Glorioso, Jaime, Elgilani, Faysal, Amiot, Bruce, Chen, Harvey, Rinaldo, Piero, Marler, Ronald, Jiang, Huailei, DeGrado, Timothy R, Suksanpaisan, Lukkana, O'Connor, Michael K, Freeman, Brittany L, Ibrahim, Samar H, Peng, Kah Whye, Harding, Cary O, Ho, Chak-Sum, Grompe, Markus, Ikeda, Yasuhiro, Lillegard, Joseph B, Russell, Stephen J, Nyberg, Scott L

“…We tested the hypothesis that ex vivo hepatocyte gene therapy can correct the metabolic disorder in fumarylacetoacetate hydrolase-deficient (Fah(-/-)) pigs, a…”
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