Search Results - "Jiang, Connie L"

Variability within rare cell states enables multiple paths toward drug resistance by Emert, Benjamin L., Cote, Christopher J., Torre, Eduardo A., Dardani, Ian P., Jiang, Connie L., Jain, Naveen, Shaffer, Sydney M., Raj, Arjun

“…Molecular differences between individual cells can lead to dramatic differences in cell fate, such as death versus survival of cancer cells upon drug…”
Get full text

Cell type determination for cardiac differentiation occurs soon after seeding of human-induced pluripotent stem cells by Jiang, Connie L, Goyal, Yogesh, Jain, Naveen, Wang, Qiaohong, Truitt, Rachel E, Coté, Allison J, Emert, Benjamin, Mellis, Ian A, Kiani, Karun, Yang, Wenli, Jain, Rajan, Raj, Arjun

“…Cardiac differentiation of human-induced pluripotent stem (hiPS) cells consistently produces a mixed population of cardiomyocytes and non-cardiac cell types,…”
Get full text

Visualizing allele-specific expression in single cells reveals epigenetic mosaicism in an H19 loss-of-imprinting mutant by Ginart, Paul, Kalish, Jennifer M, Jiang, Connie L, Yu, Alice C, Bartolomei, Marisa S, Raj, Arjun

“…Imprinting is a classic mammalian epigenetic phenomenon that results in expression from a single parental allele. Imprinting defects can lead to inappropriate…”
Get full text

ClonoCluster: A method for using clonal origin to inform transcriptome clustering by Richman, Lee P., Goyal, Yogesh, Jiang, Connie L., Raj, Arjun

“…Clustering cells based on their high-dimensional profiles is an important data reduction process by which researchers infer distinct cellular states. The…”
Get full text

ClampFISH detects individual nucleic acid molecules using click chemistry–based amplification by Rouhanifard, Sara H, Mellis, Ian A, Dunagin, Margaret, Bayatpour, Sareh, Jiang, Connie L, Dardani, Ian, Symmons, Orsolya, Emert, Benjamin, Torre, Eduardo, Cote, Allison, Sullivan, Alessandra, Stamatoyannopoulos, John A, Raj, Arjun

“…Sensitive detection of individual RNA and DNA molecules is achieved by exponentially amplifying the fluorescence signal. Methods for detecting single nucleic…”
Get full text

ClampFISH 2.0 enables rapid, scalable amplified RNA detection in situ by Dardani, Ian, Emert, Benjamin L., Goyal, Yogesh, Jiang, Connie L., Kaur, Amanpreet, Lee, Jasmine, Rouhanifard, Sara H., Alicea, Gretchen M., Fane, Mitchell E., Xiao, Min, Herlyn, Meenhard, Weeraratna, Ashani T., Raj, Arjun

“…RNA labeling in situ has enormous potential to visualize transcripts and quantify their levels in single cells, but it remains challenging to produce high…”
Get full text

Genetic screening for single-cell variability modulators driving therapy resistance by Torre, Eduardo A., Arai, Eri, Bayatpour, Sareh, Jiang, Connie L., Beck, Lauren E., Emert, Benjamin L., Shaffer, Sydney M., Mellis, Ian A., Fane, Mitchell E., Alicea, Gretchen M., Budinich, Krista A., Weeraratna, Ashani T., Shi, Junwei, Raj, Arjun

“…Cellular plasticity describes the ability of cells to transition from one set of phenotypes to another. In melanoma, transient fluctuations in the molecular…”
Get full text

The Protective Role of Transcription Factor Nrf2 in Murine Macrophage Activation Syndrome by Gallo, Paul M, Elliott, Em, Ford, Grace C, Biswas, Chhanda, Wheaton, Jadyn M, Kim, Jihwan, Jiang, Connie L, Chu, Niansheng, Kreiger, Portia A, Lambert, Michele P, Behrens, Edward M

“…Macrophage activation syndrome (MAS) is characterized by multi-lineage cytopenias, hypercytokinemia, and tissue hemophagocytosis. Transcription factor Nrf2 is…”
Get full text

Correction: Amendments: Author Correction: ClampFISH detects individual nucleic acid molecules using click chemistry–based amplification by Rouhanifard, Sara H, Mellis, Ian A, Dunagin, Margaret, Bayatpour, Sareh, Jiang, Connie L, Dardani, Ian, Symmons, Orsolya, Emert, Benjamin, Torre, Eduardo, Cote, Allison, Sullivan, Alessandra, Stamatoyannopoulos, John A, Raj, Arjun

“…Nat. Biotechnol.; 10.1038/nbt.4286; corrected online 18 December 2018 In the supplementary information originally posted, there were errors in the primer…”
Get full text

Variability within rare cell states enables multiple paths towards drug resistance by Emert, Benjamin L., Cote, Christopher, Torre, Eduardo A., Dardani, Ian P., Jiang, Connie L., Jain, Naveen, Shaffer, Sydney M., Raj, Arjun

“…Molecular differences between individual cells can lead to dramatic differences in cell fate, such as death versus survival of cancer cells upon drug…”
Get full text

Amendments: Author Correction: ClampFISH detects individual nucleic acid molecules using click chemistry-based amplification by Rouhanifard, Sara H, Mellis, Ian A, Dunagin, Margaret, Bayatpour, Sareh, Jiang, Connie L, Dardani, Ian, Symmons, Orsolya, Emert, Benjamin, Torre, Eduardo, Cote, Allison, Sullivan, Alessandra, Stamatoyannopoulos, John A, Raj, Arjun

Get full text