Search Results - "Jiang, Allen Y."
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Combinatorial development of nebulized mRNA delivery formulations for the lungs
Published in Nature nanotechnology (01-03-2024)“…Inhaled delivery of mRNA has the potential to treat a wide variety of diseases. However, nebulized mRNA lipid nanoparticles (LNPs) face several unique…”
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Zwitterionic Polymer-Functionalized Lipid Nanoparticles for the Nebulized Delivery of mRNA
Published in Journal of the American Chemical Society (13-11-2024)“…Lipid nanoparticles (LNPs) have great potential to enable inhaled delivery of mRNA to treat pulmonary diseases. However, this potential has been limited by the…”
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Journal Article -
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Accelerating ionizable lipid discovery for mRNA delivery using machine learning and combinatorial chemistry
Published in Nature materials (01-07-2024)“…To unlock the full promise of messenger (mRNA) therapies, expanding the toolkit of lipid nanoparticles is paramount. However, a pivotal component of lipid…”
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Journal Article