Search Results - "Jian-rong Gao"
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Immunotherapy with engineered bacteria by targeting the STING pathway for anti-tumor immunity
Published in Nature communications (01-06-2020)“…Synthetic biology is a powerful tool to create therapeutics which can be rationally designed to enable unique and combinatorial functionalities. Here we…”
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2
Evaluating the coherence and time-domain profile of quantum cascade laser frequency combs
Published in Optics express (26-01-2015)“…Recently, much attention has been focused on the generation of optical frequency combs from quantum cascade lasers. We discuss how fast detectors can be used…”
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Enantioselective Arylative Dearomatization of Indoles via Pd-Catalyzed Intramolecular Reductive Heck Reactions
Published in Journal of the American Chemical Society (22-04-2015)“…A highly enantioselective intramolecular arylative dearomatization of indoles via palladium-catalyzed reductive Heck reactions was developed. The new strategy…”
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4
Highly Enantioselective Construction of Trifluoromethylated All-Carbon Quaternary Stereocenters via Nickel-Catalyzed Friedel–Crafts Alkylation Reaction
Published in Journal of the American Chemical Society (27-02-2013)“…A highly enantioselective Friedel–Crafts alkylation reaction of indoles with β-CF3-β-disubstituted nitroalkenes was achieved using a Ni(ClO4)2–bisoxazoline…”
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5
Engineered bacteria producing aryl‐hydrocarbon receptor agonists protect against ethanol‐induced liver disease in mice
Published in Alcoholism, clinical and experimental research (01-05-2023)“…Background and Purpose Gut bacteria metabolize tryptophan into indoles. Intestinal levels of the tryptophan metabolite indole‐3‐acetic acid are reduced in…”
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6
Terahertz multiheterodyne spectroscopy using laser frequency combs
Published in Optica (20-05-2016)“…The terahertz region is of great importance for spectroscopy since many molecules have absorption fingerprints there. Frequency combs based on terahertz…”
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Dual Catalysis for the Redox Annulation of Nitroalkynes with Indoles: Enantioselective Construction of Indolin-3-ones Bearing Quaternary Stereocenters
Published in Angewandte Chemie International Edition (14-09-2015)“…The enantioselective redox annulation of nitroalkynes with indoles is enabled by gold/chiral phosphoric acid dual catalysis. A range of indolin‐3‐one…”
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An engineered bacterial therapeutic lowers urinary oxalate in preclinical models and in silico simulations of enteric hyperoxaluria
Published in Molecular systems biology (01-03-2022)“…Enteric hyperoxaluria (EH) is a metabolic disease caused by excessive absorption of dietary oxalate leading to the formation of chronic kidney stones and…”
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9
Ti/Au TES 32 × 32 Pixel Array: Uniformity, Thermal Crosstalk and Performance at Different X-Ray Energies
Published in IEEE transactions on applied superconductivity (01-08-2021)“…Large format arrays of transition edge sensor (TES) are crucial for the next generation of X-ray space observatories. Such arrays are required to achieve an…”
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Thermal Crosstalk of X-Ray Transition-Edge Sensor Micro-Calorimeters Under Frequency Domain Multiplexing Readout
Published in IEEE transactions on applied superconductivity (01-01-2022)“…We have measured and characterized the thermal crosstalk in two different arrays of transition-edge sensor (TES) X-ray microcalorimeters with frequency-domain…”
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Palladium-Catalyzed Three-Component Cascade Reaction: Facial Access to Densely Functionalized Indolizines
Published in Chemistry : a European journal (04-05-2015)“…A palladium‐catalyzed three‐component cascade reaction of 2‐(2‐enynyl)pyridines with nucleophiles and allyl halides has been developed, enabling the synthesis…”
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Single Pixel Performance of a 32 × 32 Ti/Au TES Array With Broadband X-Ray Spectra
Published in IEEE transactions on applied superconductivity (01-08-2021)“…We are developing a kilo-pixels Ti/Au TES array as a backup option for Athena X-IFU. Here we report on single-pixel performance of a 32 × 32 array operated in…”
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13
Chiral phosphoric acid catalyzed asymmetric hydrogenolysis of racemic 3-aryl-3-hydroxyisoindolin-1-ones
Published in Tetrahedron letters (12-06-2013)“…The enantioselective hydrogenolysis of racemic 3-aryl-3-hydroxyisoindolin-1-ones catalyzed by BINOL-derived chiral phosphoric acid with benzothiazoline as the…”
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14
Nickel-Catalyzed Intramolecular Nucleophilic Addition of Aryl or Vinyl Chlorides to α-Ketoamides Through CCl Bond Activation
Published in Chemistry : a European journal (02-05-2011)“…Nickeleophilic addition! The first example of a nickel‐catalyzed direct intramolecular nucleophilic addition of aryl or vinyl chlorides to α‐ketoamides through…”
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15
Noise Measurements of a Low-Noise Amplifier in the FDM Readout System for SAFARI
Published in Journal of low temperature physics (01-05-2020)“…The SPICA-SAFARI instrument requires extremely sensitive transition edge sensor (TES) arrays with a noise equivalent power of 2 × 10 - 19 W/ Hz and a readout…”
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16
Sequential Cu(II)-promoted oxidation/[3 + 2] cycloaddition/aromatization tandem reaction for the synthesis of 2-substituted benzo[f]isoindole-4,9-dione
Published in Canadian journal of chemistry (01-11-2020)“…An efficient method for the synthesis of 2-substituted benzo[f]isoindole-4,9-dione derivatives from N-substituted iminodiacetates and quinones via a…”
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17
A novel GSK-3β inhibitor YQ138 prevents neuronal injury induced by glutamate and brain ischemia through activation of the Nrf2 signaling pathway
Published in Acta pharmacologica Sinica (01-06-2016)“…Aim: To discover neuroprotective compounds and to characterize the discovered active compound YQ138 as a novel GSK-313 inhibitor. Methods: Primary rat…”
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18
Novel organic dye sensitizers containing fluorenyl and biphenyl moieties for solar cells
Published in Chinese chemical letters (01-02-2017)“…Three novel triarylamine dyes(AFL1-AFL3) containing fluorenyl and the biphenyl moieties have been designed and synthesized for application in dye-sensitized…”
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19
Terahertz laser frequency combs
Published in Nature photonics (01-06-2014)“…Terahertz light can be used to identify numerous complex molecules, but has traditionally remained unexploited due to the lack of powerful broadband sources…”
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20
Synthesis and fluorescence characteristics of selective ratiometric fluorescent sensors for silver ions based on 3-indolyl-4-indazolyl maleimide derivatives
Published in Research on chemical intermediates (01-07-2018)“…Selective ratiometric fluorescent sensor b for detection of silver ions and its counterparts ( sensor a and c ) were efficiently synthesized based on…”
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