Search Results - "Jia, Yichang"

Dual-gRNA approach with limited off-target effect corrects C9ORF72 repeat expansion in vivo by Piao, Xuejiao, Meng, Dawei, Zhang, Xue, Song, Qiang, Lv, Hailong, Jia, Yichang

“…C9ORF72 GGGGCC repeat expansion is the most common genetic cause for amyotrophic lateral sclerosis and frontotemporal dementia, which generates abnormal DNA…”
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Three-dimensional surface motion capture of multiple freely moving pigs using MAMMAL by An, Liang, Ren, Jilong, Yu, Tao, Hai, Tang, Jia, Yichang, Liu, Yebin

“…Understandings of the three-dimensional social behaviors of freely moving large-size mammals are valuable for both agriculture and life science, yet…”
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Activity-induced histone modifications govern Neurexin-1 mRNA splicing and memory preservation by Ding, Xinlu, Liu, Sanxiong, Tian, Miaomiao, Zhang, Wenhao, Zhu, Tao, Li, Dongdong, Wu, Jiawei, Deng, HaiTeng, Jia, Yichang, Xie, Wei, Xie, Hong, Guan, Ji-Song

“…Relatively little is known about the mechanisms that preserve memories during long-term storage. The authors found that neural activation during learning…”
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An L1 retrotransposon insertion–induced deafness mouse model for studying the development and function of the cochlear stria vascularis by Song, Chenmeng, Li, Jie, Liu, Shuang, Hou, Hanqing, Zhu, Tong, Chen, Jiaofeng, Liu, Lian, Jia, Yichang, Xiong, Wei

“…Dysregulation of ion and potential homeostasis in the scala media is the most prevalent cause of hearing loss in mammals. However, it is not well understood…”
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Mutation of a U2 snRNA Gene Causes Global Disruption of Alternative Splicing and Neurodegeneration by Jia, Yichang, Mu, John C., Ackerman, Susan L.

“…Although uridine-rich small nuclear RNAs (U-snRNAs) are essential for pre-mRNA splicing, little is known regarding their function in the regulation of…”
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Critical role of TRPC6 channels in the formation of excitatory synapses by Wang, Yizheng, Zhou, Jian, Du, Wanlu, Zhou, Kechun, Tai, Yilin, Yao, Hailan, Jia, Yichang, Ding, Yuqiang

“…The transient receptor potential canonical (TRPC) channels are Ca2+-permeable, nonselective cation channels with different biological functions, but their…”
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An ENU-induced mutation in Twist1 transactivation domain causes hindlimb polydactyly with complete penetrance and dominant-negatively impairs E2A-dependent transcription by Chen, Run-Ze, Cheng, Xuebo, Tan, Yuexi, Chang, Tien-Chien, Lv, Hailong, Jia, Yichang

“…Twist1 encodes a basic helix-loop-helix transcription factor (TF), which forms homodimer or heterodimer with other TFs, like E2A, to regulate target genes’…”
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Identification of a Novel ENU-Induced Mutation in Mouse Tbx1 Linked to Human DiGeorge Syndrome by Jia, Yichang, Song, Chenmeng, Li, Jie, Zhang, Xue, Chen, Jiaofeng, Xiong, Wei

“…The patients with DiGeorge syndrome (DGS), caused by deletion containing dozens of genes in chromosome 22, often carry cardiovascular problem and hearing loss…”
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TCF7L2 acts as a molecular switch in midbrain to control mammal vocalization through its DNA binding domain but not transcription activation domain by Qi, Huihui, Luo, Li, Lu, Caijing, Chen, Runze, Zhou, Xianyao, Zhang, Xiaohui, Jia, Yichang

“…Vocalization is an essential medium for social signaling in birds and mammals. Periaqueductal gray (PAG) a conserved midbrain structure is believed to be…”
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Correction to: TCF7L2 acts as a molecular switch in midbrain to control mammal vocalization through its DNA binding domain but not transcription activation domain by Qi, Huihui, Luo, Li, Lu, Caijing, Chen, Runze, Zhou, Xianyao, Zhang, Xiaohui, Jia, Yichang

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Expression of TCF7L2 in midbrain Vglut2-positive neurons by Qi, Huihui, Luo, Li, Lu, Caijing, Chen, Runze, Zhang, Xiaohui, Jia, Yichang

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TRPC Channels and Neuron Development, Plasticity, and Activities by Tai, Yilin, Jia, Yichang

“…In this chapter, we mainly focus on the functions of TRPC channels in brain development, including neural progenitor proliferation, neurogenesis, neuron…”
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TRPC Channels and Programmed Cell Death by Zhou, Jian, Jia, Yichang

“…Neurotrophins, including nerve growth factor (NGF) and brain-derived neurotrophic factor (BDNF), bind to their high-affinity receptors to promote neuronal…”
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Disruption of ER ion homeostasis maintained by an ER anion channel CLCC1 contributes to ALS-like pathologies by Guo, Liang, Mao, Qionglei, He, Ji, Liu, Xiaoling, Piao, Xuejiao, Luo, Li, Hao, Xiaoxu, Yu, Hanzhi, Song, Qiang, Xiao, Bailong, Fan, Dongsheng, Gao, Zhaobing, Jia, Yichang

“…Although anion channel activities have been demonstrated in sarcoplasmic reticulum/endoplasmic reticulum (SR/ER), their molecular identities and functions…”
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In vivo stress granule misprocessing evidenced in a FUS knock-in ALS mouse model by Zhang, Xue, Wang, Fengchao, Hu, Yi, Chen, Runze, Meng, Dawei, Guo, Liang, Lv, Hailong, Guan, Jisong, Jia, Yichang

“…Many RNA-binding proteins, including TDP-43, FUS, and TIA1, are stress granule components, dysfunction of which causes amyotrophic lateral sclerosis (ALS)…”
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A molecular brake that modulates spliceosome pausing at detained introns contributes to neurodegeneration by Meng, Dawei, Zheng, Qian, Zhang, Xue, Piao, Xuejiao, Luo, Li, Jia, Yichang

“…Emerging evidence suggests that intron-detaining transcripts (IDTs) are a nucleus-detained and polyadenylated mRNA pool for cell to quickly and effectively…”
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Loss of Clcc1 results in ER stress, misfolded protein accumulation, and neurodegeneration by Jia, Yichang, Jucius, Thomas J, Cook, Susan A, Ackerman, Susan L

“…Folding of transmembrane and secretory proteins occurs in the lumen of the endoplasmic reticulum (ER) before transportation to the cell surface and is…”
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TRPC channels promote cerebellar granule neuron survival by Wang, Yizheng, Jia, Yichang, Zhou, Jian, Tai, Yilin

“…Channels formed by the transient receptor potential (TRP) family of proteins have a variety of physiological functions. Here we report that two members of the…”
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Global Disruption of Alternative Splicing and Neurodegeneration Is Caused by Mutation of a U2 snRNA Gene by Jia, Yichang, Mu, John C., Ackerman, Susan L.

“…Although uridine-rich small nuclear RNAs (U-snRNAs) are essential for pre-mRNA splicing, little is known regarding their function in the regulation of…”
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Characterization of ZNF23, a KRAB-containing protein that is downregulated in human cancers and inhibits cell cycle progression by Huang, Chuanxin, Jia, Yichang, Yang, Shenglian, Chen, Biao, Sun, Hongwei, Shen, Feng, Wang, Yizheng

“…The Krupple-associated box-containing zinc-finger proteins (KRAB–ZFPs) make up one of the largest family of transcription factors. Several members of the…”
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