Search Results - "Jia, Meirong"

Genome of Tripterygium wilfordii and identification of cytochrome P450 involved in triptolide biosynthesis by Tu, Lichan, Su, Ping, Zhang, Zhongren, Gao, Linhui, Wang, Jiadian, Hu, Tianyuan, Zhou, Jiawei, Zhang, Yifeng, Zhao, Yujun, Liu, Yuan, Song, Yadi, Tong, Yuru, Lu, Yun, Yang, Jian, Xu, Cao, Jia, Meirong, Peters, Reuben J., Huang, Luqi, Gao, Wei

“…Triptolide is a trace natural product of Tripterygium wilfordii . It has antitumor activities, particularly against pancreatic cancer cells. Identification of…”
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Extending a Single Residue Switch for Abbreviating Catalysis in Plant ent -Kaurene Synthases by Jia, Meirong, Peters, Reuben J

“…Production of -kaurene as a precursor for important signaling molecules such as the gibberellins seems to have arisen early in plant evolution, with…”
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Probing the promiscuity of ent-kaurene oxidases via combinatorial biosynthesis by Mafu, Sibongile, Jia, Meirong, Zi, Jiachen, Morrone, Dana, Wu, Yisheng, Xu, Meimei, Hillwig, Matthew L., Peters, Reuben J.

“…The substrate specificity of enzymes from natural products’ metabolism is a topic of considerable interest, with potential biotechnological use implicit in the…”
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CRISPR-Cas9-based genome-editing technologies in engineering bacteria for the production of plant-derived terpenoids by Sun, Xin, Zhang, Haobin, Jia, Yuping, Li, Jingyi, Jia, Meirong

“…Terpenoids are widely used as medicines, flavors, and biofuels. However, the use of these natural products is largely restricted by their low abundance in…”
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Product Rearrangement from Altering a Single Residue in the Rice syn-Copalyl Diphosphate Synthase by Potter, Kevin C, Jia, Meirong, Hong, Young J, Tantillo, Dean, Peters, Reuben J

“…Through site-directed mutagenesis targeted at identification of the catalytic base in the rice (Oryza sativa) syn-copalyl diphosphate synthase OsCPS4, changes…”
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Author Correction: Genome of Tripterygium wilfordii and identification of cytochrome P450 involved in triptolide biosynthesis by Tu, Lichan, Su, Ping, Zhang, Zhongren, Gao, Linhui, Wang, Jiadian, Hu, Tianyuan, Zhou, Jiawei, Zhang, Yifeng, Zhao, Yujun, Liu, Yuan, Song, Yadi, Tong, Yuru, Lu, Yun, Yang, Jian, Xu, Cao, Jia, Meirong, Peters, Reuben J., Huang, Luqi, Gao, Wei

“…An amendment to this paper has been published and can be accessed via a link at the top of the paper…”
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Identification of a Dolabellane Type Diterpene Synthase and other Root-Expressed Diterpene Synthases in Arabidopsis by Wang, Qiang, Jia, Meirong, Huh, Jung-Hyun, Muchlinski, Andrew, Peters, Reuben J, Tholl, Dorothea

“…maintains a complex metabolism for the production of secondary or specialized metabolites. Such metabolites include volatile and semivolatile terpenes, which…”
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Jasmonic Acid Transport in Wound-Induced Systemic Immunity by Jia, Meirong

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Novel aminopeptidase N (APN/CD13) inhibitors derived from chloramphenicol amine by Jia, Meirong, Yang, Kanghui, Fang, Hao, Xu, Yingying, Sun, Siwei, Su, Li, Xu, Wenfang

“…A series of compounds derived from (1S,2S)-2-amino-1-(4-nitrophenyl) propane-1,3-diol have been designed, synthesized as potential APN inhibitors…”
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A pair of threonines mark ent-kaurene synthases for phytohormone biosynthesis by Brown, Reid, Jia, Meirong, Peters, Reuben J.

“…All land plants (embryophytes) must contain an ent-kaurene synthase (KS), as the ability to produce this olefin from ent-copalyl diphosphate (ent-CPP) is…”
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Extreme promiscuity of a bacterial and a plant diterpene synthase enables combinatorial biosynthesis by Jia, Meirong, Potter, Kevin C., Peters, Reuben J.

“…Diterpenes are widely distributed across many biological kingdoms, where they serve a diverse range of physiological functions, and some have significant…”
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cis or trans with class II diterpene cyclases by Jia, Meirong, Peters, Reuben J

“…Isoprenoid precursors readily undergo (poly)cyclization in electrophilic reaction cascades, presumably as internal addition of the carbon-carbon double-bonds…”
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Direct production of dihydroxylated sesquiterpenoids by a maize terpene synthase by Liang, Jin, Liu, Jiang, Brown, Reid, Jia, Meirong, Zhou, Ke, Peters, Reuben J., Wang, Qiang

“…Summary The astounding structural and biological diversities of the large class of terpenoid natural products are imparted by both their complex hydrocarbon…”
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A Pair of Residues That Interactively Affect Diterpene Synthase Product Outcome by Jia, Meirong, Zhou, Ke, Tufts, Samuel, Schulte, Samuel, Peters, Reuben J

“…The labdane-related diterpenoids (LRDs) are an important superfamily of natural products whose structural diversity critically depends on the hydrocarbon…”
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Cytochrome P450‐catalyzed biosynthesis of furanoditerpenoids in the bioenergy crop switchgrass (Panicum virgatum L.) by Muchlinski, Andrew, Jia, Meirong, Tiedge, Kira, Fell, Jason S., Pelot, Kyle A., Chew, Lisl, Davisson, Danielle, Chen, Yuxuan, Siegel, Justin, Lovell, John T., Zerbe, Philipp

“…SUMMARY Specialized diterpenoid metabolites are important mediators of plant–environment interactions in monocot crops. To understand metabolite functions in…”
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Switching on a Nontraditional Enzymatic BaseDeprotonation by Serine in the ent-Kaurene Synthase from Bradyrhizobium japonicum by Jia, Meirong, Zhang, Yue, Siegel, Justin B, Tantillo, Dean J, Peters, Reuben J

“…Terpene synthases often catalyze complex carbocation cascade reactions. It has been previously shown that single-residue switches involving replacement of a…”
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Combinatorial biosynthesis and the basis for substrate promiscuity in class I diterpene synthases by Jia, Meirong, Mishra, Sambit K., Tufts, Samuel, Jernigan, Robert L., Peters, Reuben J.

“…Terpene synthases are capable of mediating complex reactions, but fundamentally simply catalyze lysis of allylic diphosphate esters with subsequent…”
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A specific UDP-glucosyltransferase catalyzes the formation of triptophenolide glucoside from Tripterygium wilfordii Hook. f by Ma, Baowei, Liu, Xihong, Lu, Yun, Ma, Xiaochi, Wu, Xiaoyi, Wang, Xing, Jia, Meirong, Su, Ping, Tong, Yuru, Guan, Hongyu, Jiang, Zhouqian, Gao, Jie, Huang, Luqi, Gao, Wei

“…Tripterygium wilfordii Hook. f. is a perennial woody vine member of the Celastraceae family. As a traditional Chinese medicine, it contains complex chemical…”
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Direct production of di-hydroxylated sesquiterpenoids by a maize terpene synthase by Liang, Jin, Liu, Jiang, Brown, Reid, Jia, Meirong, Zhou, Ke, Peters, Reuben J., Wang, Qiang

“…The astounding structural and biological diversity of the large class of terpenoid natural products are imparted by both their complex hydrocarbon backbones…”
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Premutilin Synthase: Ring Rearrangement by a Class II Diterpene Cyclase by Xu, Meimei, Jia, Meirong, Hong, Young J, Yin, Xihou, Tantillo, Dean J, Proteau, Philip J, Peters, Reuben J

“…Biosynthesis of the complex diterpenoid antibiotic pleuromutilin relies on a bifunctional (di)­terpene synthase, and here site-directed mutagenesis was used to…”
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