Search Results - "Jia, Christina Y.H."
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Systematic identification of SH3 domain-mediated human protein-protein interactions by peptide array target screening
Published in Proteomics (Weinheim) (01-06-2007)“…Systematic identification of direct protein-protein interactions is often hampered by difficulties in expressing and purifying the corresponding full-length…”
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Novel Src Homology 3 Domain-binding Motifs Identified from Proteomic Screen of a Pro-rich Region
Published in Molecular & cellular proteomics (01-08-2005)“…The Src homology (SH) 3 domain has been shown recently to bind peptide sequences that lack the canonical P XX P motif. The diverse specificity in ligand…”
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Dual Functional Roles for the X-linked Lymphoproliferative Syndrome Gene Product SAP/SH2D1A in Signaling through the Signaling Lymphocyte Activation Molecule (SLAM) Family of Immune Receptors
Published in The Journal of biological chemistry (07-02-2003)“…The X-linked lymphoproliferative (XLP) syndrome gene encodes a protein named SAP or SH2D1A that is composed of a single Src homology 2 (SH2) domain. Two models…”
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A Functional Nuclear Localization Signal in Insulin-Like Growth Factor Binding Protein-6 Mediates Its Nuclear Import
Published in Endocrinology (Philadelphia) (01-03-2008)“…IGF binding protein (IGFBP)-6 is a member of the IGFBP family that regulates the actions of IGFs. Although IGFBPs exert their functions extracellularly in an…”
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A Novel Transmembrane Protein Recruits Numb to the Plasma Membrane during Asymmetric Cell Division
Published in The Journal of biological chemistry (19-03-2004)“…Numb, an evolutionarily conserved cell fate-determining factor, plays a pivotal role in the development of Drosophila and vertebrate nervous systems. Despite…”
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Disease-Causing SAP Mutants Are Defective in Ligand Binding and Protein Folding
Published in Biochemistry (Easton) (23-12-2003)“…The X-linked lymphoproliferative (XLP) syndrome is caused by mutations or deletions in the SH2D1A gene that encodes an SH2 domain protein named SH2D1A or SAP…”
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