Search Results - "Ji, Xinjun"

Domain-focused CRISPR screen identifies HRI as a fetal hemoglobin regulator in human erythroid cells by Grevet, Jeremy D, Lan, Xianjiang, Hamagami, Nicole, Edwards, Christopher R, Sankaranarayanan, Laavanya, Ji, Xinjun, Bhardwaj, Saurabh K, Face, Carolyne J, Posocco, David F, Abdulmalik, Osheiza, Keller, Cheryl A, Giardine, Belinda, Sidoli, Simone, Garcia, Ben A, Chou, Stella T, Liebhaber, Stephen A, Hardison, Ross C, Shi, Junwei, Blobel, Gerd A

“…Increasing fetal hemoglobin (HbF) levels in adult red blood cells provides clinical benefit to patients with sickle cell disease and some forms of…”
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MicroRNA silencing through RISC recruitment of eIF6 by Liebhaber, Stephen A, Ji, Xinjun, Chendrimada, Thimmaiah P, Gregory, Richard I, Pasquinelli, Amy E, Baillat, David, Shiekhattar, Ramin, Finn, Kenneth J

“…MicroRNAs (miRNAs) are a class of small RNAs that act post-transcriptionally to regulate messenger RNA stability and translation. To elucidate how miRNAs…”
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Cytoplasmic poly(A) binding protein-1 binds to genomically encoded sequences within mammalian mRNAs by Kini, Hemant K, Silverman, Ian M, Ji, Xinjun, Gregory, Brian D, Liebhaber, Stephen A

“…The functions of the major mammalian cytoplasmic poly(A) binding protein, PABPC1, have been characterized predominantly in the context of its binding to the 3'…”
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αCP Poly(C) Binding Proteins Act as Global Regulators of Alternative Polyadenylation by Ji, Xinjun, Wan, Ji, Vishnu, Melanie, Xing, Yi, Liebhaber, Stephen A.

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Hypoxia-mediated Selective mRNA Translation by an Internal Ribosome Entry Site-independent Mechanism by Young, Regina M., Wang, Shang-Jui, Gordan, John D., Ji, Xinjun, Liebhaber, Stephen A., Simon, M. Celeste

“…Although it is advantageous for hypoxic cells to inhibit protein synthesis and conserve energy, it is also important to translate mRNAs critical for adaptive…”
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Nonsense Mutations in Close Proximity to the Initiation Codon Fail to Trigger Full Nonsense-mediated mRNA Decay by Inácio, Angela, Silva, Ana Luísa, Pinto, Joana, Ji, Xinjun, Morgado, Ana, Almeida, Fátima, Faustino, Paula, Lavinha, João, Liebhaber, Stephen A, Romão, Luísa

“…Nonsense-mediated mRNA decay (NMD) is a surveillance mechanism that degrades mRNAs containing premature translation termination codons. In mammalian cells, a…”
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Butyrate increases the efficiency of translation of γ-globin mRNA by Weinberg, Rona S., Ji, Xinjun, Sutton, Millicent, Perrine, Susan, Galperin, Yelena, Li, Qiliang, Liebhaber, Stephen A., Stamatoyannopoulos, George, Atweh, George F.

“…Fetal hemoglobin (Hb F) levels increase in most patients with sickle cell disease following intermittent butyrate therapy. Although the full effects of…”
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The 3′ Untranslated Region Complex Involved in Stabilization of Human α-globin mRNA Assembles in the Nucleus and Serves an Independent Role as a Splice Enhancer by Ji, Xinjun, Kong, Jian, Carstens, Russ P., Liebhaber, Stephen A.

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In Vivo Association of the Stability Control Protein αCP with Actively Translating mRNAs by Ji, Xinjun, Kong, Jian, Liebhaber, Stephen A.

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The KH-Domain Protein αCP Has a Direct Role in mRNA Stabilization Independent of Its Cognate Binding Site by Kong, Jian, Ji, Xinjun, Liebhaber, Stephen A.

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A cytosine-rich splice regulatory determinant enforces functional processing of the human α-globin gene transcript by Ji, Xinjun, Humenik, Jesse, Liebhaber, Stephen A.

“…The establishment of efficient and stable splicing patterns in terminally differentiated cells is critical to maintenance of specific functions throughout the…”
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PolyC-binding proteins enhance expression of the CDK2 cell cycle regulatory protein via alternative splicing by Ji, Xinjun, Humenik, Jesse, Yang, Daphne, Liebhaber, Stephen A

“…Abstract The PolyC binding proteins (PCBPs) impact alternative splicing of a subset of mammalian genes that are enriched in basic cellular functions. Here, we…”
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RNA-Binding Proteins PCBP1 and PCBP2 Are Critical Determinants of Murine Erythropoiesis by Ji, Xinjun, Jha, Anupama, Humenik, Jesse, Ghanem, Louis R., Kromer, Andrew, Duncan-Lewis, Christopher, Traxler, Elizabeth, Weiss, Mitchell J., Barash, Yoseph, Liebhaber, Stephen A.

“…We previously demonstrated that the two paralogous RNA-binding proteins PCBP1 and PCBP2 are individually essential for mouse development: Pcbp1-null embryos…”
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αCP binding to a cytosine-rich subset of polypyrimidine tracts drives a novel pathway of cassette exon splicing in the mammalian transcriptome by Ji, Xinjun, Park, Juw Won, Bahrami-Samani, Emad, Lin, Lan, Duncan-Lewis, Christopher, Pherribo, Gordon, Xing, Yi, Liebhaber, Stephen A

“…Alternative splicing (AS) is a robust generator of mammalian transcriptome complexity. Splice site specification is controlled by interactions of cis-acting…”
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An RNA-protein complex links enhanced nuclear 3′ processing with cytoplasmic mRNA stabilization by Ji, Xinjun, Kong, Jian, Liebhaber, Stephen A

“…Post‐transcriptional controls are critical to gene regulation. These controls are frequently based on sequence‐specific binding of trans ‐acting proteins to…”
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Poly(C)-Binding Protein Pcbp2 Enables Differentiation of Definitive Erythropoiesis by Directing Functional Splicing of the Runx1 Transcript by Ghanem, Louis R., Kromer, Andrew, Silverman, Ian M., Ji, Xinjun, Gazzara, Matthew, Nguyen, Nhu, Aguilar, Gabrielle, Martinelli, Massimo, Barash, Yoseph, Liebhaber, Stephen A.

“…Formation of the mammalian hematopoietic system is under a complex set of developmental controls. Here, we report that mouse embryos lacking the KH domain…”
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DNA-protein interaction at erythroid important regulatory elements of MEL cells byin vivo footprinting by Ji Xinjun, Liu Depei, Xu, Dongdong, Li, Lei, Wang, Jing, Liang Zhiquan

“…Using ligation-mediated PCR method to study the status of DNA-protein interaction at hypersensitive site 2 of locus control Region and βmaj promoter of MEL…”
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An RNA-protein complex links enhanced nuclear 3′ processing with cytoplasmic mRNA stabilization: A novel upstream enhancer of 3′ processing by Ji, Xinjun, Kong, Jian, Liebhaber, Stephen A

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Hypoxia induces IGFBP3 in esophageal squamous cancer cells through HIF‐1α‐mediated mRNA transcription and continuous protein synthesis by Natsuizaka, Mitsuteru, Naganuma, Seiji, Kagawa, Shingo, Ohashi, Shinya, Ahmadi, Azal, Subramanian, Harry, Chang, Sanders, Nakagawa, Kei J., Ji, Xinjun, Liebhaber, Stephen A., Klein‐Szanto, Andres J., Nakagawa, Hiroshi

“…Insulin‐like growth factor binding protein (IGFBP)‐3 regulates cell proliferation and apoptosis in esophageal squamous cell carcinoma (ESCC) cells. We have…”
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PERK-dependent regulation of IAP translation during ER stress by Hamanaka, R B, Bobrovnikova-Marjon, E, Ji, X, Liebhaber, S A, Diehl, J A

“…Exposure of cells to endoplasmic reticulum (ER) stress leads to activation of phosphatidylinositol 3-kinase (PI3K)–Akt signaling pathway and transcriptional…”
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