Search Results - "Ji, Quanjiang"

Programmed genome editing by a miniature CRISPR-Cas12f nuclease by Wu, Zhaowei, Zhang, Yifei, Yu, Haopeng, Pan, Deng, Wang, Yujue, Wang, Yannan, Li, Fan, Liu, Chang, Nan, Hao, Chen, Weizhong, Ji, Quanjiang

“…The RNA-guided CRISPR-associated (Cas) nucleases are versatile tools for genome editing in various organisms. The large sizes of the commonly used Cas9 and…”
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Enhancement of prime editing via xrRNA motif-joined pegRNA by Zhang, Guiquan, Liu, Yao, Huang, Shisheng, Qu, Shiyuan, Cheng, Daolin, Yao, Yuan, Ji, Quanjiang, Wang, Xiaolong, Huang, Xingxu, Liu, Jianghuai

“…The prime editors (PEs) have shown great promise for precise genome modification. However, their suboptimal efficiencies present a significant technical…”
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Rapid and Efficient Genome Editing in Staphylococcus aureus by Using an Engineered CRISPR/Cas9 System by Chen, Weizhong, Zhang, Yifei, Yeo, Won-Sik, Bae, Taeok, Ji, Quanjiang

“…Staphylococcus aureus, a major human pathogen, has been the cause of serious infectious diseases with a high mortality rate. Although genetics is a key means…”
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Structure and mechanism of the essential two-component signal-transduction system WalKR in Staphylococcus aureus by Ji, Quanjiang, Chen, Peter J., Qin, Guangrong, Deng, Xin, Hao, Ziyang, Wawrzak, Zdzislaw, Yeo, Won-Sik, Quang, Jenny Winjing, Cho, Hoonsik, Luo, Guan-Zheng, Weng, Xiaocheng, You, Qiancheng, Luan, Chi-Hao, Yang, Xiaojing, Bae, Taeok, Yu, Kunqian, Jiang, Hualiang, He, Chuan

“…Most low GC Gram-positive bacteria possess an essential walKR two-component system (TCS) for signal transduction involved in regulating cell wall homoeostasis…”
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Emergence of plasmid-mediated high-level tigecycline resistance genes in animals and humans by He, Tao, Wang, Ran, Liu, Dejun, Walsh, Timothy R., Zhang, Rong, Lv, Yuan, Ke, Yuebin, Ji, Quanjiang, Wei, Ruicheng, Liu, Zhihai, Shen, Yingbo, Wang, Gang, Sun, Lichang, Lei, Lei, Lv, Ziquan, Li, Yun, Pang, Maoda, Wang, Liyuan, Sun, Qiaoling, Fu, Yulin, Song, Huangwei, Hao, Yuxin, Shen, Zhangqi, Wang, Shaolin, Chen, Gongxiang, Wu, Congming, Shen, Jianzhong, Wang, Yang

“…Tigecycline is a last-resort antibiotic that is used to treat severe infections caused by extensively drug-resistant bacteria. tet (X) has been shown to encode…”
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Capsule type defines the capability of Klebsiella pneumoniae in evading Kupffer cell capture in the liver by Huang, Xueting, Li, Xiuyuan, An, Haoran, Wang, Juanjuan, Ding, Ming, Wang, Lijun, Li, Lulu, Ji, Quanjiang, Qu, Fen, Wang, Hui, Xu, Yingchun, Lu, Xinxin, He, Yuan, Zhang, Jing-Ren

“…Polysaccharide capsule is the main virulence factor of K . pneumoniae , a major pathogen of bloodstream infections in humans. While more than 80 capsular…”
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Molecular basis for the PAM expansion and fidelity enhancement of an evolved Cas9 nuclease by Chen, Weizhong, Zhang, Hongyuan, Zhang, Yifei, Wang, Yu, Gan, Jianhua, Ji, Quanjiang

“…Clustered regularly interspaced short palindromic repeats (CRISPR)-Cas systems have been harnessed as powerful genome editing tools in diverse organisms…”
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CRISPR/Cas9-based Genome Editing in Pseudomonas aeruginosa and Cytidine Deaminase-Mediated Base Editing in Pseudomonas Species by Chen, Weizhong, Zhang, Ya, Zhang, Yifei, Pi, Yishuang, Gu, Tongnian, Song, Liqiang, Wang, Yu, Ji, Quanjiang

“…Pseudomonas species are a large class of gram-negative bacteria that exhibit significant biomedical, ecological, and industrial importance. Despite the…”
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Anti-infective therapy using species-specific activators of Staphylococcus aureus ClpP by Wei, Bingyan, Zhang, Tao, Wang, Pengyu, Pan, Yihui, Li, Jiahui, Chen, Weizhong, Zhang, Min, Ji, Quanjiang, Wu, Wenjuan, Lan, Lefu, Gan, Jianhua, Yang, Cai-Guang

“…The emergence of methicillin-resistant Staphylococcus aureus isolates highlights the urgent need to develop more antibiotics. ClpP is a highly conserved…”
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BacPE: a versatile prime-editing platform in bacteria by inhibiting DNA exonucleases by Zhang, Hongyuan, Ma, Jiacheng, Wu, Zhaowei, Chen, Xiaoyang, Qian, Yangyang, Chen, Weizhong, Wang, Zhipeng, Zhang, Ya, Zhu, Huanhu, Huang, Xingxu, Ji, Quanjiang

“…Prime editing allows precise installation of any single base substitution and small insertions and deletions without requiring homologous recombination or…”
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Development of a versatile nuclease prime editor with upgraded precision by Li, Xiangyang, Zhang, Guiquan, Huang, Shisheng, Liu, Yao, Tang, Jin, Zhong, Mingtian, Wang, Xin, Sun, Wenjun, Yao, Yuan, Ji, Quanjiang, Wang, Xiaolong, Liu, Jianghuai, Zhu, Shiqiang, Huang, Xingxu

“…The applicability of nuclease-based form of prime editor (PEn) has been hindered by its complexed editing outcomes. A chemical inhibitor against DNA-PK, which…”
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CRISPR-CBEI: a Designing and Analyzing Tool Kit for Cytosine Base Editor-Mediated Gene Inactivation by Yu, Haopeng, Wu, Zhaowei, Chen, Xiangdan, Ji, Quanjiang, Tao, Shiheng

“…Life science has been in pursuit of precise and efficient genome editing in living cells since the very beginning of the first restriction cloning attempt. The…”
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Protein cysteine phosphorylation of SarA/MgrA family transcriptional regulators mediates bacterial virulence and antibiotic resistance by Sun, Fei, Ding, Yue, Ji, Quanjiang, Liang, Zhongjie, Deng, Xin, Wong, Catherine C. L, Yi, Chengqi, Zhang, Liang, Xie, Sherrie, Alvarez, Sophie, Hicks, Leslie M, Luo, Cheng, Jiang, Hualiang, Lan, Lefu, He, Chuan

“…Protein posttranslational modifications (PTMs), particularly phosphorylation, dramatically expand the complexity of cellular regulatory networks. Although…”
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Expression of Multidrug Resistance Efflux Pump Gene norA Is Iron Responsive in Staphylococcus aureus by Deng, Xin, Sun, Fei, Ji, Quanjiang, Liang, Haihua, Missiakas, Dominique, Lan, Lefu, He, Chuan

“…Staphylococcus aureus utilizes efflux transporter NorA to pump out a wide range of structurally dissimilar drugs, conferring low-level multidrug resistance…”
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EasyCatch, a convenient, sensitive and specific CRISPR detection system for cancer gene mutations by Liu, Yin, Chen, Yanling, Dang, Lu, Liu, Yixin, Huang, Shisheng, Wu, Sanyun, Ma, Peixiang, Jiang, Hongqiang, Li, Yi, Pan, Yunbao, Wei, Yongchang, Ma, Xiaodong, Liu, Ming, Ji, Quanjiang, Chi, Tian, Huang, Xingxu, Wang, Xinjie, Zhou, Fuling

“…Keywords: CRISPR detection, cancer mutation, Drug resistance, Leukemia, SNP detection…”
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Virulence-related regulatory network of Pseudomonas syringae by Huang, Jiadai, Yao, Chunyan, Sun, Yue, Ji, Quanjiang, Deng, Xin

“…Transcription factors (TFs) play important roles in regulating multiple biological processes by binding to promoter regions and regulating the global gene…”
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Quorum-sensing agr mediates bacterial oxidation response via an intramolecular disulfide redox switch in the response regulator AgrA by Sun, Fei, Liang, Haihua, Kong, Xiangqian, Xie, Sherrie, Cho, Hoonsik, Deng, Xin, Ji, Quanjiang, Zhang, Haiyan, Alvarez, Sophie, Hicks, Leslie M., Bae, Taeok, Luo, Cheng, Jiang, Hualiang, He, Chuan

“…Oxidation sensing and quorum sensing significantly affect bacterial physiology and host–pathogen interactions. However, little attention has been paid to the…”
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Lectin-Based Nanoprobes Functionalized with Enzyme for Highly Sensitive Electrochemical Monitoring of Dynamic Carbohydrate Expression on Living Cells by Ding, Lin, Ji, Quanjiang, Qian, Ruocan, Cheng, Wei, Ju, Huangxian

“…A dual-functionalized nanoprobe was designed for highly sensitive and selective in situ evaluation of carbohydrates on living cells by integrating the specific…”
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The auxiliary protein complex SaePQ activates the phosphatase activity of sensor kinase SaeS in the SaeRS two-component system of Staphylococcus aureus by Jeong, Do-Won, Cho, Hoonsik, Jones, Marcus B., Shatzkes, Kenneth, Sun, Fei, Ji, Quanjiang, Liu, Qian, Peterson, Scott N., He, Chuan, Bae, Taeok

“…Summary In bacterial two‐component regulatory systems (TCSs), dephosphorylation of phosphorylated response regulators is essential for resetting the activated…”
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Pseudomonas aeruginosa Global Regulator VqsR Directly Inhibits QscR To Control Quorum-Sensing and Virulence Gene Expression by Liang, Haihua, Deng, Xin, Ji, Quanjiang, Sun, Fei, Shen, Tuo, He, Chuan

“…The opportunistic pathogen Pseudomonas aeruginosa has at least three quorum-sensing (QS) systems, including the acyl-homoserine lactone (acyl-HSL)-mediated las…”
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