Search Results - "Jhun, Min A."

A Statistical Approach for Testing Cross-Phenotype Effects of Rare Variants by Broadaway, K. Alaine, Cutler, David J., Duncan, Richard, Moore, Jacob L., Ware, Erin B., Jhun, Min A., Bielak, Lawrence F., Zhao, Wei, Smith, Jennifer A., Peyser, Patricia A., Kardia, Sharon L.R., Ghosh, Debashis, Epstein, Michael P.

“…Increasing empirical evidence suggests that many genetic variants influence multiple distinct phenotypes. When cross-phenotype effects exist, multivariate…”
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Characterization of european ancestry nonalcoholic fatty liver disease‐associated variants in individuals of african and hispanic descent by Palmer, Nicholette D., Musani, Solomon K., Yerges‐Armstrong, Laura M., Feitosa, Mary F., Bielak, Lawrence F., Hernaez, Ruben, Kahali, Bratati, Carr, J. Jeffrey, Harris, Tamara B., Jhun, Min A., Kardia, Sharon L.R., Langefeld, Carl D., Mosley, Thomas H., Norris, Jill M., Smith, Albert V., Taylor, Herman A., Wagenknecht, Lynne E., Liu, Jiankang, Borecki, Ingrid B., Peyser, Patricia A., Speliotes, Elizabeth K.

“…Nonalcoholic fatty liver disease (NAFLD) is an obesity‐related condition affecting over 50% of individuals in some populations and is expected to become the…”
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A Statistical Approach for Rare-Variant Association Testing in Affected Sibships by Epstein, Michael P., Duncan, Richard, Ware, Erin B., Jhun, Min A., Bielak, Lawrence F., Zhao, Wei, Smith, Jennifer A., Peyser, Patricia A., Kardia, Sharon L.R., Satten, Glen A.

“…Sequencing and exome-chip technologies have motivated development of novel statistical tests to identify rare genetic variation that influences complex…”
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Deep-coverage whole genome sequences and blood lipids among 16,324 individuals by Natarajan, Pradeep, Peloso, Gina M., Zekavat, Seyedeh Maryam, Montasser, May, Ganna, Andrea, Chaffin, Mark, Khera, Amit V., Zhou, Wei, Bloom, Jonathan M., Engreitz, Jesse M., Ernst, Jason, O’Connell, Jeffrey R., Ruotsalainen, Sanni E., Alver, Maris, Manichaikul, Ani, Johnson, W. Craig, Perry, James A., Poterba, Timothy, Seed, Cotton, Surakka, Ida L., Esko, Tonu, Ripatti, Samuli, Salomaa, Veikko, Correa, Adolfo, Vasan, Ramachandran S., Kellis, Manolis, Neale, Benjamin M., Lander, Eric S., Abecasis, Goncalo, Mitchell, Braxton, Rich, Stephen S., Wilson, James G., Cupples, L. Adrienne, Rotter, Jerome I., Willer, Cristen J., Kathiresan, Sekar

“…Large-scale deep-coverage whole-genome sequencing (WGS) is now feasible and offers potential advantages for locus discovery. We perform WGS in 16,324…”
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A genome-wide approach accounting for body mass index identifies genetic variants influencing fasting glycemic traits and insulin resistance by Hivert, Marie-France, Scott, Robert A, Grimsby, Jonna L, Chen, Han, Amin, Najaf, Barnes, Daniel, Cadby, Gemma, Hottenga, Jouke-Jan, Ingelsson, Erik, Kanoni, Stavroula, Ladenvall, Claes, Lagou, Vasiliki, Liu, Yongmei, Martinez-Larrad, Maria Teresa, Navarro, Pau, Strawbridge, Rona J, Tanaka, Toshiko, de Andrade, Mariza, Aulchenko, Yurii, Balkau, Beverley, Beilby, John P, Blangero, John, Boban, Mladen, Boomsma, Dorret I, Böttcher, Yvonne, Bouchard, Claude, Budimir, Danijela, Clarke, Robert, Corbatón-Anchuelo, Arturo, Couper, David, Dedoussis, George V, Erdos, Michael R, Eriksson, Johan G, Franzosi, Maria Grazia, Franks, Paul W, Galan, Pilar, de Geus, Eco, Hallmans, Göran, Hansson, Ola, Harris, Tamara B, Hayward, Caroline, Hingorani, Aroon, Johnson, Paul C D, Jukema, J Wouter, Jula, Antti, Kolcic, Ivana, Kumari, Meena, Lakka, Timo, Lannfelt, Lars, Lathrop, G Mark, Lind, Lars, Lobbens, Stéphane, Loos, Ruth J F, Lyssenko, Valeriya, Magnusson, Patrik K E, Marmot, Michael, Meneton, Pierre, Mooser, Vincent, Morken, Mario A, Ong, Ken K, Oostra, Ben A, Palmer, Lyle J, Palotie, Aarno, Peden, John F, Pedersen, Nancy L, Penninx, Brenda, Perola, Markus, Peyser, Patricia A, Räikkönen, Katri, Rehnberg, Emil, Rotter, Jerome I, Rudan, Igor, Ruokonen, Aimo, Saaristo, Timo, Sabater-Lleal, Maria, Salomaa, Veikko, Saxena, Richa, Sennblad, Bengt, Shuldiner, Alan R, Sijbrands, Eric J G, Small, Kerrin S, Smith, Nicholas L, Sun, Yan V, Tuomilehto, Jaakko, Uitterlinden, Andre G, Vikström, Max, Vitart, Veronique, Vohl, Marie-Claude, Voight, Benjamin F, Waeber, Gerard, Wheeler, Eleanor, Widen, Elisabeth, Willemsen, Gonneke, Wilson, James F, Witteman, Jacqueline C M, Yaghootkar, Hanieh, Barroso, Ines, Watanabe, Richard M, Florez, Jose C, Meigs, James B

“…Claudia Langenberg, James Meigs and colleagues apply a joint meta-analysis approach that accounts for differences in body mass index to identify variants…”
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An integrative cross-omics analysis of DNA methylation sites of glucose and insulin homeostasis by Liu, Jun, Carnero-Montoro, Elena, van Dongen, Jenny, Lent, Samantha, Nedeljkovic, Ivana, Ligthart, Symen, Tsai, Pei-Chien, Martin, Tiphaine C., Mandaviya, Pooja R., Jansen, Rick, Peters, Marjolein J., Duijts, Liesbeth, Jaddoe, Vincent W. V., Tiemeier, Henning, Felix, Janine F., Willemsen, Gonneke, de Geus, Eco J. C., Chu, Audrey Y., Levy, Daniel, Hwang, Shih-Jen, Bressler, Jan, Gondalia, Rahul, Salfati, Elias L., Herder, Christian, Hidalgo, Bertha A., Tanaka, Toshiko, Moore, Ann Zenobia, Lemaitre, Rozenn N., Jhun, Min A, Smith, Jennifer A., Sotoodehnia, Nona, Bandinelli, Stefania, Ferrucci, Luigi, Arnett, Donna K., Grallert, Harald, Assimes, Themistocles L., Hou, Lifang, Baccarelli, Andrea, Whitsel, Eric A., van Dijk, Ko Willems, Amin, Najaf, Uitterlinden, André G., Sijbrands, Eric J. G., Franco, Oscar H., Dehghan, Abbas, Spector, Tim D., Dupuis, Josée, Hivert, Marie-France, Rotter, Jerome I., Meigs, James B., Pankow, James S., van Meurs, Joyce B. J., Isaacs, Aaron, Boomsma, Dorret I., Bell, Jordana T., Demirkan, Ayşe, van Duijn, Cornelia M.

“…Despite existing reports on differential DNA methylation in type 2 diabetes (T2D) and obesity, our understanding of its functional relevance remains limited…”
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Meta-analysis of epigenome-wide association studies of cognitive abilities by Marioni, Riccardo E., McRae, Allan F., Bressler, Jan, Colicino, Elena, Hannon, Eilis, Li, Shuo, Prada, Diddier, Smith, Jennifer A, Trevisi, Letizia, Tsai, Pei-Chien, Vojinovic, Dina, Simino, Jeannette, Levy, Daniel, Liu, Chunyu, Mendelson, Michael, Satizabal, Claudia L., Yang, Qiong, Jhun, Min A., Kardia, Sharon L. R., Zhao, Wei, Bandinelli, Stefania, Ferrucci, Luigi, Hernandez, Dena G., Singleton, Andrew B., Harris, Sarah E., Starr, John M., Kiel, Douglas P., McLean, Robert R., Just, Allan C., Schwartz, Joel, Spiro, Avron, Vokonas, Pantel, Amin, Najaf, Ikram, M. Arfan, Uitterlinden, Andre G., van Meurs, Joyce B. J., Spector, Tim D., Steves, Claire, Baccarelli, Andrea A., Bell, Jordana T., van Duijn, Cornelia M., Fornage, Myriam, Hsu, Yi-Hsiang, Mill, Jonathan, Mosley, Thomas H., Seshadri, Sudha, Deary, Ian J.

“…Cognitive functions are important correlates of health outcomes across the life-course. Individual differences in cognitive functions are partly heritable…”
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Epigenetic and integrative cross-omics analyses of cerebral white matter hyperintensities on MRI by Yang, Yunju, Knol, Maria J, Wang, Ruiqi, Mishra, Aniket, Liu, Dan, Luciano, Michelle, Teumer, Alexander, Armstrong, Nicola, Bis, Joshua C, Jhun, Min A, Li, Shuo, Adams, Hieab H H, Aziz, Nasir Ahmad, Bastin, Mark E, Bourgey, Mathieu, Brody, Jennifer A, Frenzel, Stefan, Gottesman, Rebecca F, Hosten, Norbert, Hou, Lifang, Kardia, Sharon L R, Lohner, Valerie, Marquis, Pascale, Maniega, Susana Muñoz, Satizabal, Claudia L, Sorond, Farzaneh A, Valdés Hernández, Maria C, van Duijn, Cornelia M, Vernooij, Meike W, Wittfeld, Katharina, Yang, Qiong, Zhao, Wei, Boerwinkle, Eric, Levy, Daniel, Deary, Ian J, Jiang, Jiyang, Mather, Karen A, Mosley, Thomas H, Psaty, Bruce M, Sachdev, Perminder S, Smith, Jennifer A, Sotoodehnia, Nona, DeCarli, Charles S, Breteler, Monique M B, Ikram, M Arfan, Grabe, Hans J, Wardlaw, Joanna, Longstreth, W T, Launer, Lenore J, Seshadri, Sudha, Debette, Stephanie, Fornage, Myriam

“…Cerebral white matter hyperintensities on MRI are markers of cerebral small vessel disease, a major risk factor for dementia and stroke. Despite the successful…”
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SNP Set Association Analysis for Familial Data by Schifano, Elizabeth D., Epstein, Michael P., Bielak, Lawrence F., Jhun, Min A., Kardia, Sharon L. R., Peyser, Patricia A., Lin, Xihong

“…Genome‐wide association studies (GWAS) are a popular approach for identifying common genetic variants and epistatic effects associated with a disease…”
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Modeling the Causal Role of DNA Methylation in the Association Between Cigarette Smoking and Inflammation in African Americans: A 2-Step Epigenetic Mendelian Randomization Study by Jhun, Min A, Smith, Jennifer A, Ware, Erin B, Kardia, Sharon L R, Mosley, Jr, Thomas H, Turner, Stephen T, Peyser, Patricia A, Park, Sung Kyun

“…The association between cigarette smoking and inflammation is well known. However, the biological mechanisms behind the association are not fully understood,…”
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Elucidating mechanisms of genetic cross-disease associations at the PROCR vascular disease locus by Stacey, David, Chen, Lingyan, Stanczyk, Paulina J., Howson, Joanna M. M., Mason, Amy M., Burgess, Stephen, MacDonald, Stephen, Langdown, Jonathan, McKinney, Harriett, Downes, Kate, Farahi, Neda, Peters, James E., Basu, Saonli, Pankow, James S., Tang, Weihong, Pankratz, Nathan, Sabater-Lleal, Maria, de Vries, Paul S., Smith, Nicholas L., Gelinas, Amy D., Schneider, Daniel J., Janjic, Nebojsa, Samani, Nilesh J., Ye, Shu, Summers, Charlotte, Chilvers, Edwin R., Danesh, John, Paul, Dirk S.

“…Many individual genetic risk loci have been associated with multiple common human diseases. However, the molecular basis of this pleiotropy often remains…”
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Gene expression signature of Gleason score is associated with prostate cancer outcomes in a radical prostatectomy cohort by Jhun, Min A, Geybels, Milan S, Wright, Jonathan L, Kolb, Suzanne, April, Craig, Bibikova, Marina, Ostrander, Elaine A, Fan, Jian-Bing, Feng, Ziding, Stanford, Janet L

“…Prostate cancer (PCa) is a leading cause of cancer-related mortality worldwide. Gleason score (GS) is one of the best predictors of PCa aggressiveness, but…”
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Testing cross‐phenotype effects of rare variants in longitudinal studies of complex traits by Rudra, Pratyaydipta, Broadaway, K. Alaine, Ware, Erin B., Jhun, Min A., Bielak, Lawrence F., Zhao, Wei, Smith, Jennifer A., Peyser, Patricia A., Kardia, Sharon L.R., Epstein, Michael P., Ghosh, Debashis

“…ABSTRACT Many gene mapping studies of complex traits have identified genes or variants that influence multiple phenotypes. With the advent of next‐generation…”
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Association of the Vitamin D Metabolism Gene CYP24A1 With Coronary Artery Calcification by Shen, Haiqing, Bielak, Lawrence F, Ferguson, Jane F, Streeten, Elizabeth A, Yerges-Armstrong, Laura M, Liu, Jie, Post, Wendy, OʼConnell, Jeffery R, Hixson, James E, Kardia, Sharon L.R, Sun, Yan V, Jhun, Min A, Wang, Xuexia, Mehta, Nehal N, Li, Mingyao, Koller, Daniel L, Hakonarson, Hakan, Keating, Brendan J, Rader, Daniel J, Shuldiner, Alan R, Peyser, Patricia A, Reilly, Muredach P, Mitchell, Braxton D

“…OBJECTIVE—The vitamin D endocrine system is essential for calcium homeostasis, and low levels of vitamin D metabolites have been associated with cardiovascular…”
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Effect modification by vitamin D receptor genetic polymorphisms in the association between cumulative lead exposure and pulse pressure: a longitudinal study by Jhun, Min A, Hu, Howard, Schwartz, Joel, Weisskopf, Marc G, Nie, Linda H, Sparrow, David, Vokonas, Pantel S, Park, Sung Kyun

“…Although the association between lead and cardiovascular disease is well established, potential mechanisms are still poorly understood. Calcium metabolism…”
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Quantitative proteomic analysis of ribosomal protein L35b mutant of Saccharomyces cerevisiae by Song, Yong Bhum, Jhun, Min A, Park, Taesung, Huh, Won-Ki

“…Recent studies have revealed that in higher eukaryotes, several ribosomal proteins are involved in some pathological events or developmental defects,…”
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Dynamic incorporation of multiple in silico functional annotations empowers rare variant association analysis of large whole-genome sequencing studies at scale by Li, Xihao, Li, Zilin, Zhou, Hufeng, Gaynor, Sheila M., Liu, Yaowu, Chen, Han, Sun, Ryan, Dey, Rounak, Arnett, Donna K., Aslibekyan, Stella, Ballantyne, Christie M., Bielak, Lawrence F., Blangero, John, Boerwinkle, Eric, Bowden, Donald W., Broome, Jai G., Conomos, Matthew P., Correa, Adolfo, Cupples, L. Adrienne, Curran, Joanne E., Freedman, Barry I., Guo, Xiuqing, Hindy, George, Irvin, Marguerite R., Kardia, Sharon L. R., Kathiresan, Sekar, Khan, Alyna T., Kooperberg, Charles L., Laurie, Cathy C., Liu, X. Shirley, Mahaney, Michael C., Manichaikul, Ani W., Martin, Lisa W., Mathias, Rasika A., McGarvey, Stephen T., Mitchell, Braxton D., Montasser, May E., Moore, Jill E., Morrison, Alanna C., O’Connell, Jeffrey R., Palmer, Nicholette D., Pampana, Akhil, Peralta, Juan M., Peyser, Patricia A., Psaty, Bruce M., Redline, Susan, Rice, Kenneth M., Rich, Stephen S., Smith, Jennifer A., Tiwari, Hemant K., Tsai, Michael Y., Vasan, Ramachandran S., Wang, Fei Fei, Weeks, Daniel E., Weng, Zhiping, Wilson, James G., Yanek, Lisa R., Neale, Benjamin M., Sunyaev, Shamil R., Abecasis, Gonçalo R., Rotter, Jerome I., Willer, Cristen J., Peloso, Gina M., Natarajan, Pradeep, Lin, Xihong

“…Large-scale whole-genome sequencing studies have enabled the analysis of rare variants (RVs) associated with complex phenotypes. Commonly used RV association…”
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DNA methylation signatures of chronic low-grade inflammation are associated with complex diseases by Ligthart, Symen, Marzi, Carola, Aslibekyan, Stella, Mendelson, Michael M, Conneely, Karen N, Tanaka, Toshiko, Colicino, Elena, Waite, Lindsay L, Joehanes, Roby, Guan, Weihua, Brody, Jennifer A, Elks, Cathy, Marioni, Riccardo, Jhun, Min A, Agha, Golareh, Bressler, Jan, Ward-Caviness, Cavin K, Chen, Brian H, Huan, Tianxiao, Bakulski, Kelly, Salfati, Elias L, Fiorito, Giovanni, Wahl, Simone, Schramm, Katharina, Sha, Jin, Hernandez, Dena G, Just, Allan C, Smith, Jennifer A, Sotoodehnia, Nona, Pilling, Luke C, Pankow, James S, Tsao, Phil S, Liu, Chunyu, Zhao, Wei, Guarrera, Simonetta, Michopoulos, Vasiliki J, Smith, Alicia K, Peters, Marjolein J, Melzer, David, Vokonas, Pantel, Fornage, Myriam, Prokisch, Holger, Bis, Joshua C, Chu, Audrey Y, Herder, Christian, Grallert, Harald, Yao, Chen, Shah, Sonia, McRae, Allan F, Lin, Honghuang, Horvath, Steve, Fallin, Daniele, Hofman, Albert, Wareham, Nicholas J, Wiggins, Kerri L, Feinberg, Andrew P, Starr, John M, Visscher, Peter M, Murabito, Joanne M, Kardia, Sharon L R, Absher, Devin M, Binder, Elisabeth B, Singleton, Andrew B, Bandinelli, Stefania, Peters, Annette, Waldenberger, Melanie, Matullo, Giuseppe, Schwartz, Joel D, Demerath, Ellen W, Uitterlinden, André G, van Meurs, Joyce B J, Franco, Oscar H, Chen, Yii-Der Ida, Levy, Daniel, Turner, Stephen T, Deary, Ian J, Ressler, Kerry J, Dupuis, Josée, Ferrucci, Luigi, Ong, Ken K, Assimes, Themistocles L, Boerwinkle, Eric, Koenig, Wolfgang, Arnett, Donna K, Baccarelli, Andrea A, Benjamin, Emelia J, Dehghan, Abbas

“…Chronic low-grade inflammation reflects a subclinical immune response implicated in the pathogenesis of complex diseases. Identifying genetic loci where DNA…”
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DNA Methylation Analysis Identifies Loci for Blood Pressure Regulation by Richard, Melissa A., Huan, Tianxiao, Ligthart, Symen, Gondalia, Rahul, Jhun, Min A., Brody, Jennifer A., Irvin, Marguerite R., Montasser, May E., Jia, Yucheng, Syme, Catriona, Salfati, Elias L., Boerwinkle, Eric, Guan, Weihua, Mosley, Thomas H., Bressler, Jan, Morrison, Alanna C., Liu, Chunyu, Mendelson, Michael M., Uitterlinden, André G., van Meurs, Joyce B., ’t Hoen, Peter A.C., van Meurs, Joyce, Isaacs, Aaron, Franke, Lude, Boomsma, Dorret I., Pool, René, Hottenga, Jouke J., van Greevenbroek, Marleen M.J., Stehouwer, Coen D.A., Wijmenga, Cisca, Zhernakova, Alexandra, Slagboom, P. Eline, Beekman, Marian, Deelen, Joris, van Heemst, Diana, Veldink, Jan H., van den Berg, Leonard H., van Duijn, Cornelia M., Hofman, Albert, Uitterlinden, André G., Jhamai, P. Mila, Verbiest, Michael, Suchiman, H. Eka D., Verkerk, Marijn, van der Breggen, Ruud, van Rooij, Jeroen, Lakenberg, Nico, Mei, Hailiang, van Iterson, Maarten, van Galen, Michiel, Bot, Jan, Nooren, Irene, Moed, Matthijs, Vermaat, Martijn, Zhernakova, Dasha V., Luijk, René, Bonder, Marc Jan, van Dijk, Freerk, Arindrarto, Wibowo, Kielbasa, Szymon M., Swertz, Morris A., van Zwet, Erik W., Franco, Oscar H., Zhang, Guosheng, Li, Yun, Stewart, James D., Bis, Joshua C., Psaty, Bruce M., Chen, Yii-Der Ida, Kardia, Sharon L.R., Zhao, Wei, Absher, Devin, Aslibekyan, Stella, Starr, John M., McRae, Allan F., Schwartz, Joel D., Vokonas, Pantel S., Menni, Cristina, Spector, Tim D., Shuldiner, Alan, Damcott, Coleen M., Rotter, Jerome I., Palmas, Walter, Liu, Yongmei, Paus, Tomáš, Horvath, Steve, O’Connell, Jeffrey R., Guo, Xiuqing, Pausova, Zdenka, Assimes, Themistocles L., Sotoodehnia, Nona, Smith, Jennifer A., Arnett, Donna K., Deary, Ian J., Baccarelli, Andrea A., Bell, Jordana T., Whitsel, Eric, Dehghan, Abbas, Levy, Daniel, Fornage, Myriam

“…Genome-wide association studies have identified hundreds of genetic variants associated with blood pressure (BP), but sequence variation accounts for a small…”
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Transethnic Genetic-Correlation Estimates from Summary Statistics by Brown, Brielin C., Ye, Chun Jimmie, Price, Alkes L., Zaitlen, Noah

“…The increasing number of genetic association studies conducted in multiple populations provides an unprecedented opportunity to study how the genetic…”
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