Search Results - "Jhiang, S. M"

The RET proto-oncogene in human cancers by Jhiang, S M

“…The activation of the RET proto-oncogene contributes to the development of human cancers in two different ways. Somatic rearrangements of RET with a variety of…”
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In vivo imaging and radioiodine therapy following sodium iodide symporter gene transfer in animal model of intracerebral gliomas by CHO, J.-Y, SHEN, D. H. Y, BARTH, R. F, JHIANG, S. M, YANG, W, WILLIAMS, B, BUCKWALTER, T. L. F, LA PERLE, K. M. D, HINKLE, G, POZDERAC, R, KLOOS, R, NAGARAJA, H. N

“…Radioactive iodide uptake (RAIU) in thyroid follicular epithelial cells, mediated by the sodium iodide symporter (NIS), is the first rate-limiting step in…”
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Long-term impact of initial surgical and medical therapy on papillary and follicular thyroid cancer by Mazzaferri, E L, Jhiang, S M

“…To determine the long-term impact of medical and surgical treatment of well differentiated papillary and follicular thyroid cancer. Patients with papillary and…”
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Do cell surface trafficking impairments account for variable cell surface sodium iodide symporter levels in breast cancer? by Beyer, S. J, Jimenez, R. E, Shapiro, C. L, Cho, J. Y, Jhiang, S. M

“…The Na⁺/I⁻ symporter (NIS) is a transmembrane glycoprotein that mediates iodide uptake into thyroid follicular cells and serves as the molecular basis of…”
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Loss of p53 Promotes Anaplasia and Local Invasion in ret/PTC1-Induced Thyroid Carcinomas by La Perle, Krista M.D., Jhiang, Sissy M., Capen, Charles C.

“…Papillary thyroid carcinomas in humans are associated with the ret/PTC oncogene and, following loss of p53 function, may progress to anaplastic carcinomas…”
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Effects of dose, intervention time, and radionuclide on sodium iodide symporter (NIS)-targeted radionuclide therapy by SHEN, D. H. Y, MARSEE, D. K, SCHAAP, J, YANG, W, CHO, J-Y, HINKLE, G, NAGARAJA, H. N, KLOOS, R. T, BARTH, R. F, JHIANG, S. M

“…The sodium iodide symporter (NIS) mediates iodide uptake into thyrocytes and is the molecular basis of thyroid radioiodine therapy. We previously have shown…”
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An immunohistochemical study of Na+/I- symporter in human thyroid tissues and salivary gland tissues by Jhiang, S M, Cho, J Y, Ryu, K Y, DeYoung, B R, Smanik, P A, McGaughy, V R, Fischer, A H, Mazzaferri, E L

“…The human Na+/I- symporter (hNIS) is the plasma membrane protein that mediates active iodide uptake into several tissues, such as the thyroid and salivary…”
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Monoclonal antibodies against the human sodium iodide symporter: utility for immunocytochemistry of thyroid cancer by Castro, MR, Bergert, ER, Beito, TG, Roche, PC, Ziesmer, SC, Jhiang, SM, Goellner, Morris, JC

“…The recent cloning of the thyroidal protein that is responsible for iodide transport, the sodium iodide symporter (hNIS), has made possible studies designed to…”
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Targeted expression of the ret/PTC1 oncogene induces papillary thyroid carcinomas by Jhiang, S M, Sagartz, J E, Tong, Q, Parker-Thornburg, J, Capen, C C, Cho, J Y, Xing, S, Ledent, C

“…The ret/PTC oncogene, a rearranged form of the ret proto-oncogene, has been found to be restricted to human papillary thyroid carcinomas. This report shows…”
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Hormonal regulation of radioiodide uptake activity and Na+/I- symporter expression in mammary glands by CHO, J.-Y, LEVEILLE, R, KAO, R, ROUSSET, B, PARLOW, A. F, BURAK, W. E, MAZZAFERRI, E. L, JHIANG, S. M

“…The observation that radioiodide uptake (RAIU) activity, mediated by the Na+/I- symporter (NIS), is significantly increased in lactating breast suggests that…”
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Expression and activity of human Na+/I- symporter in human glioma cells by adenovirus-mediated gene delivery by CHO, J.-Y, XING, S, LIU, X, BUCKWALTER, T. L. F, HWA, L, SFERRA, T. J, CHIU, I.-M, JHIANG, S. M

“…Radioiodide concentrating activity in the thyroid, mediated by human Na+/I- symporter (hNIS), provides a mechanism for effective radioiodide treatment for…”
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Novel, missense and loss-of-function mutations in the sodium/iodide symporter gene causing Iodide transport defect in three Japanese patients by KOSUGI, S, INOUE, S, MATSUDA, A, JHIANG, S. M

“…Iodide transport defect is a disorder affecting the active transport of iodide, an essential step in the synthesis of thyroid hormones. We have identified…”
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Congenital hypothyroidism due to mutations in the sodium/iodide symporter. Identification of a nonsense mutation producing a downstream cryptic 3' splice site by Pohlenz, J, Rosenthal, I M, Weiss, R E, Jhiang, S M, Burant, C, Refetoff, S

“…A 12-yr-old hypothyroid girl was diagnosed at birth as athyreotic because her thyroid gland could not be visualized by isotope scanning. Goiter development due…”
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Promoter characterization of the human Na+/I- symporter by RYU, K.-Y, QIANG TONG, JHIANG, S. M

“…The Na+/I- symporter (NIS) is the plasma membrane protein that mediates active iodide uptake into thyroid follicular cells. To understand the molecular…”
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High prevalence of T354P sodium/iodide symporter gene mutation in Japanese patients with iodide transport defect who have heterogeneous clinical pictures by KOSUGI, S, SATO, Y, MATSUDA, A, OHYAMA, Y, FUJIEDA, K, INOMATA, H, KAMEYA, T, ISOZAKI, O, JHIANG, S. M

“…A missense and loss of function mutation of the Na+/I- symporter (NIS) gene, T354P [Thr354-->Pro (ACA-->CCA)], was found in the homozygous state in two…”
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Early cellular abnormalities induced by RET/PTC1 oncogene in thyroid-targeted transgenic mice by CHO, J.-Y, SAGARTZ, J. E, CAPEN, C. C, MAZZAFERRI, E. L, JHIANG, S. M

“…The RET/PTC1 oncogene, a rearranged form of the RET proto-oncogene, has been reported to be associated with human papillary thyroid carcinomas. We have shown…”
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Detection of the PTC/retTPC oncogene in human thyroid cancers by Jhiang, S M, Caruso, D R, Gilmore, E, Ishizaka, Y, Tahira, T, Nagao, M, Chiu, I M, Mazzaferri, E L

“…We have investigated the PTC/retTPC oncogene, an activated form of ret proto-oncogene with a specific rearrangement, in thyroid malignancies. Southern analysis…”
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Cloning of the human taurine transporter and characterization of taurine uptake in thyroid cells by Jhiang, Sissy M., Fithian, Linda, Smanik, Patricia, McGill, Jeffrey, Tong, Qiang, Mazzaferri, Ernest L.

“…A cDNA clone encoding a taurine transporter, designated HTAU, has been isolated from human thyroid. It contains an open reading frame encoding a protein of 619…”
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Thyroid carcinomas in RET/PTC transgenic mice by Jhiang, S M, Cho, J Y, Furminger, T L, Sagartz, J E, Tong, Q, Capen, C C, Mazzaferri, E L

“…The RET/PTC oncogene, a rearranged form of the RET proto-oncogene, has been found to be associated with human papillary thyroid carcinomas. To investigate…”
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Breakpoint characterization of the ret/PTC oncogene in human papillary thyroid carcinoma by Smanik, P A, Furminger, T L, Mazzaferri, E L, Jhiang, S M

“…The ret/PTC oncogene, rearranged form of the ret proto-oncogene (c-ret), has been detected specifically in a minority of papillary thyroid carcinomas. Three…”
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