Search Results - "Jha, Babal K."

Antagonism of the Interferon-Induced OAS-RNase L Pathway by Murine Coronavirus ns2 Protein Is Required for Virus Replication and Liver Pathology by Zhao, Ling, Jha, Babal K., Wu, Ashley, Elliott, Ruth, Ziebuhr, John, Gorbalenya, Alexander E., Silverman, Robert H., Weiss, Susan R.

“…Many viruses induce hepatitis in humans, highlighting the need to understand the underlying mechanisms of virus-induced liver pathology. The murine…”
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Decitabine- and 5-azacytidine resistance emerges from adaptive responses of the pyrimidine metabolism network by Gu, Xiaorong, Tohme, Rita, Tomlinson, Benjamin, Sakre, Nneha, Hasipek, Metis, Durkin, Lisa, Schuerger, Caroline, Grabowski, Dale, Zidan, Asmaa M., Radivoyevitch, Tomas, Hong, Changjin, Carraway, Hetty, Hamilton, Betty, Sobecks, Ronald, Patel, Bhumika, Jha, Babal K., Hsi, Eric D., Maciejewski, Jaroslaw, Saunthararajah, Yogen

“…Mechanisms-of-resistance to decitabine and 5-azacytidine, mainstay treatments for myeloid malignancies, require investigation and countermeasures. Both are…”
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Mode and specificity of binding of the small molecule GANT61 to GLI determines inhibition of GLI-DNA binding by Agyeman, Akwasi, Jha, Babal K, Mazumdar, Tapati, Houghton, Janet A

“…The GLI genes, GLI1 and GLI2, are transcription factors that regulate target genes at the distal end of the canonical Hedgehog (HH) signaling pathway…”
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Homologous 2′,5′-phosphodiesterases from disparate RNA viruses antagonize antiviral innate immunity by Zhang, Rong, Jha, Babal K., Ogden, Kristen M., Dong, Beihua, Zhao, Ling, Elliott, Ruth, Patton, John T., Silverman, Robert H., Weiss, Susan R.

“…Efficient and productive virus infection often requires viral countermeasures that block innate immunity. The IFN-inducible 2′,5′-oligoadenylate (2-5A)…”
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Middle East Respiratory Syndrome Coronavirus NS4b Protein Inhibits Host RNase L Activation by Thornbrough, Joshua M, Jha, Babal K, Yount, Boyd, Goldstein, Stephen A, Li, Yize, Elliott, Ruth, Sims, Amy C, Baric, Ralph S, Silverman, Robert H, Weiss, Susan R

“…Middle East respiratory syndrome coronavirus (MERS-CoV) is the first highly pathogenic human coronavirus to emerge since severe acute respiratory syndrome…”
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The similarity of class II HLA genotypes defines patterns of autoreactivity in idiopathic bone marrow failure disorders by Pagliuca, Simona, Gurnari, Carmelo, Awada, Hassan, Kishtagari, Ashwin, Kongkiatkamon, Sunisa, Terkawi, Laila, Zawit, Misam, Guan, Yihong, LaFramboise, Thomas, Jha, Babal K., Patel, Bhumika J., Hamilton, Betty K., Majhail, Navneet S., Lundgren, Sofie, Mustjoki, Satu, Saunthararajah, Yogen, Visconte, Valeria, Chan, Timothy A., Yang, Chao-Yie, Lenz, Tobias L., Maciejewski, Jaroslaw P.

“…Idiopathic aplastic anemia (IAA) is a rare autoimmune bone marrow failure (BMF) disorder initiated by a human leukocyte antigen (HLA)-restricted T-cell…”
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Circulating microbial content in myeloid malignancy patients is associated with disease subtypes and patient outcomes by Woerner, Jakob, Huang, Yidi, Hutter, Stephan, Gurnari, Carmelo, Sánchez, Jesús María Hernández, Wang, Janet, Huang, Yimin, Schnabel, Daniel, Aaby, Michael, Xu, Wanying, Thorat, Vedant, Jiang, Dongxu, Jha, Babal K., Koyuturk, Mehmet, Maciejewski, Jaroslaw P., Haferlach, Torsten, LaFramboise, Thomas

“…Although recent work has described the microbiome in solid tumors, microbial content in hematological malignancies is not well-characterized. Here we analyze…”
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Eltrombopag inhibits TET dioxygenase to contribute to hematopoietic stem cell expansion in aplastic anemia by Guan, Yihong, Hasipek, Metis, Jiang, Dongxu, Tiwari, Anand D, Grabowski, Dale R, Pagliuca, Simona, Kongkiatkamon, Sunisa, Patel, Bhumika, Singh, Salendra, Parker, Yvonne, LaFramboise, Thomas, Lindner, Daniel, Sekeres, Mikkael A, Mian, Omar Y, Saunthararajah, Yogen, Maciejewski, Jaroslaw P, Jha, Babal K

“…Eltrombopag, an FDA-approved non-peptidyl thrombopoietin receptor agonist, is clinically used for the treatment of aplastic anemia, a disease characterized by…”
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Molecular and clinical analyses of PHF6 mutant myeloid neoplasia provide their pathogenesis and therapeutic targeting by Kubota, Yasuo, Gu, Xiaorong, Terkawi, Laila, Bodo, Juraj, Przychodzen, Bartlomiej P., Awada, Hussein, Williams, Nakisha, Gurnari, Carmelo, Kawashima, Naomi, Aly, Mai, Durmaz, Arda, Mori, Minako, Ponvilawan, Ben, Kewan, Tariq, Bahaj, Waled, Meggendorfer, Manja, Jha, Babal K., Visconte, Valeria, Rogers, Heesun J., Haferlach, Torsten, Maciejewski, Jaroslaw P.

“…PHF6 mutations ( PHF6 MT ) are identified in various myeloid neoplasms (MN). However, little is known about the precise function and consequences of PHF6 in…”
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Germline loss-of-function SAMD9 and SAMD9L alterations in adult myelodysplastic syndromes by Nagata, Yasunobu, Narumi, Satoshi, Guan, Yihong, Przychodzen, Bartlomiej P., Hirsch, Cassandra M., Makishima, Hideki, Shima, Hirohito, Aly, Mai, Pastor, Victor, Kuzmanovic, Teodora, Radivoyevitch, Tomas, Adema, Vera, Awada, Hassan, Yoshida, Kenichi, Li, Samuel, Sole, Francesc, Hanna, Rabi, Jha, Babal K., LaFramboise, Thomas, Ogawa, Seishi, Sekeres, Mikkael A., Wlodarski, Marcin W., Cammenga, Jörg, Maciejewski, Jaroslaw P.

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Genomics of therapy-related myeloid neoplasms by Kuzmanovic, Teodora, Patel, Bhumika J, Sanikommu, Srinivasa R, Nagata, Yasunobu, Awada, Hassan, Kerr, Cassandra M, Przychodzen, Bartlomiej P, Jha, Babal K, Hiwase, Devendra, Singhal, Deepak, Advani, Anjali S, Nazha, Aziz, Gerds, Aaron T, Carraway, Hetty E, Sekeres, Mikkael A, Mukherjee, Sudipto, Maciejewski, Jaroslaw P, Radivoyevitch, Tomas

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Ribonuclease L and metal-ion–independent endoribonuclease cleavage sites in host and viral RNAs by Cooper, Daphne A., Jha, Babal K., Silverman, Robert H., Hesselberth, Jay R., Barton, David J.

“…Ribonuclease L (RNase L) is a metal-ion–independent endoribonuclease associated with antiviral and antibacterial defense, cancer and lifespan. Despite the…”
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Sulfur Amino Acid Supplementation Abrogates Protective Effects of Caloric Restriction for Enhancing Bone Marrow Regrowth Following Ionizing Radiation by Hine, Christopher, Treviño-Villarreal, J Humberto, Mejia, Pedro, Longchamp, Alban, Brace, Lear E, Harputlugil, Eylul, Mitchell, Sarah J, Yang, Jie, Guan, Yihong, Maciejewski, Jaroslaw P, Jha, Babal K, Mitchell, James R

“…Radiation therapy damages and depletes total bone marrow (BM) cellularity, compromising safety and limiting effective dosing. Aging also strains total BM and…”
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Therapeutic Targeting of Protein Disulfide Isomerase PDIA1 in Multiple Myeloma by Hasipek, Metis, Grabowski, Dale, Guan, Yihong, Alugubelli, Raghunandan Reddy, Tiwari, Anand D., Gu, Xiaorong, DeAvila, Gabriel A., Silva, Ariosto S., Meads, Mark B., Parker, Yvonne, Lindner, Daniel J., Saunthararajah, Yogen, Shain, Kenneth H., Maciejewski, Jaroslaw P., Reu, Frederic J., Phillips, James G., Jha, Babal K.

“…Multiple myeloma is a genetically complex hematologic neoplasia in which malignant plasma cells constantly operate at the maximum limit of their unfolded…”
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Murine AKAP7 has a 2',5'-phosphodiesterase domain that can complement an inactive murine coronavirus ns2 gene by Gusho, Elona, Zhang, Rong, Jha, Babal K, Thornbrough, Joshua M, Dong, Beihua, Gaughan, Christina, Elliott, Ruth, Weiss, Susan R, Silverman, Robert H

“…Viral 2',5'-phosphodiesterases (2',5'-PDEs) help disparate RNA viruses evade the antiviral activity of interferon (IFN) by degrading 2',5'-oligoadenylate…”
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Invariant phenotype and molecular association of biallelic TET2 mutant myeloid neoplasia by Awada, Hassan, Nagata, Yasunobu, Goyal, Abhinav, Asad, Mohammad F., Patel, Bhumika, Hirsch, Cassandra M., Kuzmanovic, Teodora, Guan, Yihong, Przychodzen, Bartlomiej P., Aly, Mai, Adema, Vera, Shen, Wenyi, Williams, Louis, Nazha, Aziz, Abazeed, Mohamed E., Sekeres, Mikkael A., Radivoyevitch, Tomas, Haferlach, Torsten, Jha, Babal K., Visconte, Valeria, Maciejewski, Jaroslaw P.

“…Somatic TET2 mutations (TET2MT) are frequent in myeloid neoplasia (MN), particularly chronic myelomonocytic leukemia (CMML). TET2MT includes mostly…”
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Context dependent effects of ascorbic acid treatment in TET2 mutant myeloid neoplasia by Guan, Yihong, Greenberg, Edward F., Hasipek, Metis, Chen, Shi, Liu, Xiaochen, Kerr, Cassandra M., Gackowski, Daniel, Zarakowska, Ewelina, Radivoyevitch, Tomas, Gu, Xiaorong, Willard, Belinda, Visconte, Valeria, Makishima, Hideki, Nazha, Aziz, Mukherji, Mridul, Sekeres, Mikkael A., Saunthararajah, Yogen, Oliński, Ryszard, Xu, Mingjiang, Maciejewski, Jaroslaw P., Jha, Babal K.

“…Loss-of-function TET2 mutations ( TET2 MT ) are common in myeloid neoplasia. TET2, a DNA dioxygenase, requires 2-oxoglutarate and Fe(II) to oxidize…”
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TET2 mutation as prototypic clonal hematopoiesis lesion by Guarnera, Luca, Jha, Babal K.

“…Loss of function TET2 mutation (TET2MT) is one of the most frequently observed lesions in clonal hematopoiesis (CH). TET2 a member TET-dioxygenase family of…”
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Clinical and basic implications of dynamic T cell receptor clonotyping in hematopoietic cell transplantation by Pagliuca, Simona, Gurnari, Carmelo, Hong, Sanghee, Zhao, Ran, Kongkiatkamon, Sunisa, Terkawi, Laila, Zawit, Misam, Guan, Yihong, Awada, Hassan, Kishtagari, Ashwin, Kerr, Cassandra M, LaFramboise, Thomas, Patel, Bhumika J, Jha, Babal K, Carraway, Hetty E, Visconte, Valeria, Majhail, Navneet S, Hamilton, Betty K, Maciejewski, Jaroslaw P

“…TCR repertoire diversification constitutes a foundation for successful immune reconstitution after allogeneic hematopoietic cell transplantation (allo-HCT)…”
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A geno-clinical decision model for the diagnosis of myelodysplastic syndromes by Radakovich, Nathan, Meggendorfer, Manja, Malcovati, Luca, Hilton, C. Beau, Sekeres, Mikkael A., Shreve, Jacob, Rouphail, Yazan, Walter, Wencke, Hutter, Stephan, Galli, Anna, Pozzi, Sara, Elena, Chiara, Padron, Eric, Savona, Michael R., Gerds, Aaron T., Mukherjee, Sudipto, Nagata, Yasunobu, Komrokji, Rami S., Jha, Babal K., Haferlach, Claudia, Maciejewski, Jaroslaw P., Haferlach, Torsten, Nazha, Aziz

“…The differential diagnosis of myeloid malignancies is challenging and subject to interobserver variability. We used clinical and next-generation sequencing…”
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