Search Results - "Jezequel, S G"

THE DISPOSITION OF VORICONAZOLE IN MOUSE, RAT, RABBIT, GUINEA PIG, DOG, AND HUMAN by ROFFEY, S. J, COLE, S, COMBY, P, GIBSON, D, JEZEQUEL, S. G, NEDDERMAN, A. N. R, SMITH, D. A, WALKER, D. K, WOOD, N

“…Voriconazole is a new triazole antifungal agent with potent, wide-spectrum activity. Its pharmacokinetics and metabolism have been studied in mouse, rat,…”
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The disposition and metabolism of [14C]fluconazole in humans by Brammer, K W, Coakley, A J, Jezequel, S G, Tarbit, M H

“…The disposition and metabolism of 14C-labeled fluconazole (100 microCi) was determined in three healthy male subjects after administration of a single oral…”
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Fluconazole: interspecies scaling and allometric relationships of pharmacokinetic properties by Jezequel, S G

“…Fluconazole is a novel azole antifungal agent with low lipophilicity and high metabolic stability which has been investigated pharmacokinetically in six animal…”
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Role of sialylation in determining the pharmacokinetics of neutrophil inhibitory factor (NIF) in the Fischer 344 rat by Webster, R., Taberner, J., Edgington, A., Guhan, S., Varghese, J., Feeney, H., Blocker, L., Jezequel, S. G.

“…1. Recombinant neutrophil inhibitory factor (NIF) is a glycoprotein. Its amino acid sequence remains constant and has a molecular weight of 28.9 kD. However,…”
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Modipafant, a new PAF antagonist: pharmacokinetics and disposition in rat, dog and man by Jezequel, S G, Uden, S, Wastall, P

“…1. The pharmacokinetics and disposition of modipafant, a dihydropyridine PAF antagonist, were studied in rat and dog following intravenous and oral…”
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The effect of drug lipophilicity on P-glycoprotein-mediated colchicine efflux at the blood-brain barrier by Khan, E U, Reichel, A, Begley, D J, Roffey, S J, Jezequel, S G, Abbott, N J

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Metabolism of xenobiotics by Beauveria bassiana by Griffiths, D A, Brown, D E, Jezequel, S G

“…1. Diazepam, warfarin and testosterone were metabolized by whole resting cells of the fungus Beauveria bassiana IMI 12939 via oxidative reactions such as…”
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The screening of selected microorganisms for use as models of mammalian drug metabolism by GRIFFITHS, D. A, BEST, D. J, JEZEQUEL, S. G

“…Fifty fungi and two Streptomyces species were screened for their ability to metabolise the probe substrates aminopyrine, diazepam, testosterone, theophylline…”
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Biotransformation of warfarin by the fungus Beauveria bassiana by GRIFFITHS, D. A, BROWN, D. E, JEZEQUEL, S. G

“…Biotransformation of racemic warfarin by the fungus Beauveria bassiana IMI 12939 was studied as part of an investigation into alternative methods for the…”
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Bioanalytical data in decision making: discovery and development by Smith, D A, Beaumont, K, Cussans, N J, Humphrey, M J, Jezequel, S G, Rance, D J, Stopher, D A, Walker, D K

“…1. Bioanalysis is traditionally associated with the development phase of drugs; its use in discovery programmes is often ignored but can have a major impact…”
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Microbial models of mammalian metabolism: uses and misuses (clarification of some misconceptions) by Jezequel, Serge G.

“…Oxidative metabolism is the most commonly encountered metabolic clearance pathway of xenobiotics by mammalian systems. Similar pathways are often encountered…”
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O-dealkylation: a newly discovered class of reactions catalysed by the soluble mono-oxygenase of the methanotroph Methylosinus trichosporium OB3b by JEZEQUEL, S. G, KAYE, B, HIGGINS, I. J

“…Cell-free extracts of Methylosinus trichosporium OB3b (MT OB3b) containing the soluble, broad specificity methane mono-oxygenase (MMO) have been shown to…”
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O-dealkylation: A newly discovered class of reactions catalysed by the soluble mono-oxygenase of the methanotroph Methylosinus trichosporium 0B3b by Jezequel, S. G., Kaye, B., Higgins, I. J.

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