Search Results - "Jewell, Sharon L."
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Simultaneous monitoring of potassium, glucose and lactate during spreading depolarization in the injured human brain – Proof of principle of a novel real-time neurochemical analysis system, continuous online microdialysis
Published in Journal of cerebral blood flow and metabolism (01-05-2017)“…Spreading depolarizations occur spontaneously and frequently in injured human brain. They propagate slowly through injured tissue often cycling around a local…”
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Clinical translation of microfluidic sensor devices: focus on calibration and analytical robustness
Published in Lab on a chip (07-08-2019)“…We present approaches to facilitate the use of microfluidics outside of the laboratory, in our case within a clinical setting and monitoring from human…”
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3D printed microfluidic device for online detection of neurochemical changes with high temporal resolution in human brain microdialysate
Published in Lab on a chip (07-06-2019)“…This paper presents the design, optimisation and fabrication of a mechanically robust 3D printed microfluidic device for the high time resolution online…”
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Which Spreading Depolarizations Are Deleterious To Brain Tissue?
Published in Neurocritical care (01-02-2020)“…Spreading depolarizations (SDs) are profound disruptions of cellular homeostasis that slowly propagate through gray matter and present an extraordinary…”
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Detection of Spreading Depolarization with Intraparenchymal Electrodes in the Injured Human Brain
Published in Neurocritical care (01-02-2014)“…Background Spreading depolarization events following ischemic and traumatic brain injury are associated with poor patient outcome. Currently, monitoring these…”
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Recording, analysis, and interpretation of spreading depolarizations in neurointensive care: Review and recommendations of the COSBID research group
Published in Journal of Cerebral Blood Flow & Metabolism (01-05-2017)“…Spreading depolarizations (SD) are waves of abrupt, near-complete breakdown of neuronal transmembrane ion gradients, are the largest possible pathophysiologic…”
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