Search Results - "Jewell, Megan P"
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Machine Learning Establishes Single-Cell Calcium Dynamics as an Early Indicator of Antibiotic Response
Published in Microorganisms (Basel) (05-05-2021)“…Changes in bacterial physiology necessarily precede cell death in response to antibiotics. Herein we investigate the early disruption of Ca homeostasis as a…”
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LipiSensors: Exploiting Lipid Nanoemulsions to Fabricate Ionophore-Based Nanosensors
Published in Biosensors (Basel) (10-09-2020)“…Ionophore-based nanosensors (IBNS) are tools that enable quantification of analytes in complex chemical and biological systems. IBNS methodology is adopted…”
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Concizumab improves clot formation in hemophilia A under flow
Published in Journal of thrombosis and haemostasis (01-09-2024)“…Inhibition of tissue factor pathway inhibitor (TFPI) is an emerging therapeutic strategy for treatment of hemophilia. Concizumab is a monoclonal antibody that…”
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Luminescent Nanosensors for Ratiometric Monitoring of Three-Dimensional Oxygen Gradients in Laboratory and Clinical Pseudomonas aeruginosa Biofilms
Published in Applied and environmental microbiology (15-10-2019)“…Bacterial biofilms can form persistent infections on wounds and implanted medical devices and are associated with many chronic diseases, such as cystic…”
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A review of chemosensors and biosensors for monitoring biofilm dynamics
Published in Sensors and actuators reports (01-11-2021)“…Biofilms form complex structures that are ubiquitous in natural environments and can cause chronic infections which are difficult to treat. While much is known…”
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Nanodiagnostics to monitor biofilm oxygen metabolism for antibiotic susceptibility testing
Published in Analyst (London) (07-06-2020)“…In clinical environments, many serious antibiotic-resistant infections are caused by biofilm-forming species. This presents issues when attempting to determine…”
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Triplet-Triplet Annihilation Upconversion Based Nanosensors for Fluorescence Detection of Potassium
Published in ACS sensors (28-02-2020)“…Typical ionophore-based nanosensors use Nile blue derived indicators called chromoionophores, which must contend with strong background absorption,…”
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Novel Luminescent Nanosensors and Their Applications in Quantifying and Monitoring Analyte Gradients in Bacterial Biofilms
Published 01-01-2020“…Bacterial biofilms are complex, heterogeneous communities of bacteria encased in an extracellular matrix of polysaccharides, DNA, protein, and other…”
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Dissertation