Search Results - "Jewel, Delilah"

Rewriting the genetic code by Jewel, Delilah, Chatterjee, Abhishek

“…Making room in the genetic code allows the creation of designer proteins with new building blocks The near-universally conserved genetic code governs the…”
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Rewriting the genetic code: Making room in the genetic code allows the creation of designer proteins with new building blocks by Jewel, Delilah, Chatterjee, Abhishek

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Virus-assisted Directed Evolution of Biomolecules by Jewel, Delilah, Pham, Quan, Chatterjee, Abhishek

“…Directed evolution is a powerful technique that uses principles of natural evolution to enable the development of biomolecules with novel functions. However,…”
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Virus-assisted directed evolution of enhanced suppressor tRNAs in mammalian cells by Jewel, Delilah, Kelemen, Rachel E., Huang, Rachel L., Zhu, Zeyu, Sundaresh, Bharathi, Cao, Xiaofu, Malley, Kaitlin, Huang, Zeyi, Pasha, Muhammad, Anthony, Jon, van Opijnen, Tim, Chatterjee, Abhishek

“…Site-specific incorporation of unnatural amino acids (Uaas) in living cells relies on engineered aminoacyl-transfer RNA synthetase–tRNA pairs borrowed from a…”
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An Efficient Opal‐Suppressor Tryptophanyl Pair Creates New Routes for Simultaneously Incorporating up to Three Distinct Noncanonical Amino Acids into Proteins in Mammalian Cells by Osgood, Arianna O., Zheng, Yunan, Roy, Soumya Jyoti Singha, Biris, Nikolaos, Hussain, Myer, Loynd, Conor, Jewel, Delilah, Italia, James S., Chatterjee, Abhishek

“…Site‐specific incorporation of multiple distinct noncanonical amino acids (ncAAs) into proteins in mammalian cells is a promising technology, where each ncAA…”
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Enhanced Directed Evolution in Mammalian Cells Yields a Hyperefficient Pyrrolysyl tRNA for Noncanonical Amino Acid Mutagenesis by Jewel, Delilah, Kelemen, Rachel E., Huang, Rachel L., Zhu, Zeyu, Sundaresh, Bharathi, Malley, Kaitlin, Pham, Quan, Loynd, Conor, Huang, Zeyi, Opijnen, Tim, Chatterjee, Abhishek

“…Heterologous tRNAs used for noncanonical amino acid (ncAA) mutagenesis in mammalian cells typically show poor activity. We recently introduced a virus‐assisted…”
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Photoredox‐Catalyzed Labeling of Hydroxyindoles with Chemoselectivity (PhotoCLIC) for Site‐Specific Protein Bioconjugation by Singha Roy, Soumya Jyoti, Loynd, Conor, Jewel, Delilah, Canarelli, Sarah E., Ficaretta, Elise D., Pham, Quan A., Weerapana, Eranthie, Chatterjee, Abhishek

“…We have developed a novel visible‐light‐catalyzed bioconjugation reaction, PhotoCLIC, that enables chemoselective attachment of diverse aromatic amine reagents…”
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Electrochemical labelling of hydroxyindoles with chemoselectivity for site-specific protein bioconjugation by Loynd, Conor, Singha Roy, Soumya Jyoti, Ovalle, Vincent J., Canarelli, Sarah E., Mondal, Atanu, Jewel, Delilah, Ficaretta, Elise D., Weerapana, Eranthie, Chatterjee, Abhishek

“…Electrochemistry has recently emerged as a powerful approach in small-molecule synthesis owing to its numerous attractive features, including precise control…”
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Directed Evolution of a Bacterial Leucyl tRNA in Mammalian Cells for Enhanced Noncanonical Amino Acid Mutagenesis by Huang, Rachel L., Jewel, Delilah, Kelemen, Rachel E., Pham, Quan, Yared, Tarah J., Wang, Shu, Singha Roy, Soumya Jyoti, Huang, Zeyi, Levinson, Samantha D., Sundaresh, Bharathi, Miranda, Suyen Espinoza, van Opijnen, Tim, Chatterjee, Abhishek

“…The Escherichia coli leucyl-tRNA synthetase (EcLeuRS)/tRNAEcLeu pair has been engineered to genetically encode a structurally diverse group of enabling…”
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Enhanced Directed Evolution in Mammalian Cells Yields a Hyperefficient Pyrrolysyl tRNA for Noncanonical Amino Acid Mutagenesis by Jewel, Delilah, Kelemen, Rachel E., Huang, Rachel L., Zhu, Zeyu, Sundaresh, Bharathi, Malley, Kaitlin, Pham, Quan, Loynd, Conor, Huang, Zeyi, Opijnen, Tim, Chatterjee, Abhishek

“…Heterologous tRNAs used for noncanonical amino acid (ncAA) mutagenesis in mammalian cells typically show poor activity. We recently introduced a virus‐assisted…”
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Photoredox‐Catalyzed Labeling of Hydroxyindoles with Chemoselectivity (PhotoCLIC) for Site‐Specific Protein Bioconjugation by Singha Roy, Soumya Jyoti, Loynd, Conor, Jewel, Delilah, Canarelli, Sarah E., Ficaretta, Elise D., Pham, Quan A., Weerapana, Eranthie, Chatterjee, Abhishek

“…We have developed a novel visible‐light‐catalyzed bioconjugation reaction, PhotoCLIC, that enables chemoselective attachment of diverse aromatic amine reagents…”
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An Efficient Opal‐Suppressor Tryptophanyl Pair Creates New Routes for Simultaneously Incorporating up to Three Distinct Noncanonical Amino Acids into Proteins in Mammalian Cells by Osgood, Arianna O., Zheng, Yunan, Roy, Soumya Jyoti Singha, Biris, Nikolaos, Hussain, Myer, Loynd, Conor, Jewel, Delilah, Italia, James S., Chatterjee, Abhishek

“…Site‐specific incorporation of multiple distinct noncanonical amino acids (ncAAs) into proteins in mammalian cells is a promising technology, where each ncAA…”
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d-3-Deoxy-dioctanoylphosphatidylinositol induces cytotoxicity in human MCF-7 breast cancer cells via a mechanism that involves downregulation of the D-type cyclin-retinoblastoma pathway by Gradziel, Cheryl S., Jordan, Peter A., Jewel, Delilah, Dufort, Fay J., Miller, Scott J., Chiles, Thomas C., Roberts, Mary F.

“…Phosphatidylinositol analogs (PIAs) were originally designed to bind competitively to the Akt PH domain and prevent membrane translocation and activation…”
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Itaconic acid, a missing link in macrophage activation, is produced by IRG1 by Cheng, Jiongjia, Jewel, Delilah, Chiles, Thomas C., Stec, Boguslaw, Roberts, Mary Fedarko

“…Abstract only Itaconic acid (ITA) is a metabolite produced by primary macrophages and cell lines derived from macrophages that is dramatically increased upon…”
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