Search Results - "Jevtovic‐Todorovic, Vesna"

Synthetic neuroactive steroids as new sedatives and anaesthetics: Back to the future by Manzella, Francesca M., Covey, Douglas F., Jevtovic‐Todorovic, Vesna, Todorovic, Slobodan M.

“…Since the 1990s, there has been waning interest in researching general anaesthetics (anaesthetics). Although currently used anaesthetics are mostly safe and…”
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Early exposure to general anesthesia impairs social and emotional development in rats by Diana, Paolo, Joksimovic, Srdjan M., Faisant, Azra, Jevtovic-Todorovic, Vesna

“…Several animal and emerging human studies suggest an association between an early exposure to general anesthesia (GA) and long-lasting problems with complex…”
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Novel neuroactive steroid with hypnotic and T‐type calcium channel blocking properties exerts effective analgesia in a rodent model of post‐surgical pain by Joksimovic, Sonja Lj, Joksimovic, Srdjan M., Manzella, Francesca M., Asnake, Betelehem, Orestes, Peihan, Raol, Yogendra H., Krishnan, Kathiresan, Covey, Douglas F., Jevtovic‐Todorovic, Vesna, Todorovic, Slobodan M.

“…Background and Purpose Neuroactive steroid (3β,5β,17β)‐3‐hydroxyandrostane‐17‐carbonitrile (3β‐OH) is a novel hypnotic and voltage‐dependent blocker of T‐type…”
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Potential of ketamine and midazolam, individually or in combination, to induce apoptotic neurodegeneration in the infant mouse brain by Young, Chainllie, Jevtovic‐Todorovic, Vesna, Qin, Yue‐Qin, Tenkova, Tatyana, Wang, Haihui, Labruyere, Joann, Olney, John W

“…Recently, it was reported that anesthetizing infant rats for 6 h with a combination of anesthetic drugs (midazolam, nitrous oxide, isoflurane) caused…”
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Drug-induced Apoptotic Neurodegeneration in the Developing Brain by Olney, John W., Wozniak, David F., Jevtovic-Todorovic, Vesna, Farber, Nuri B., Bittigau, Petra, Ikonomidou, Chysanthy

“…Physiological cell death (PCD), a process by which redundant or unsuccessful neurons are deleted by apoptosis (cell suicide) from the developing central…”
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Anesthesia and Cancer, Friend or Foe? A Narrative Review by Montejano, Julio, Jevtovic-Todorovic, Vesna

“…Cancer remains the leading cause of death worldwide with close to 10 million deaths reported annually. Due to growth of the advanced age cohort in our…”
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Exposure of Developing Brain to General Anesthesia by Jevtovic-Todorovic, Vesna

“…Abstract Recently, the U.S. Food and Drug Administration issued an official warning to all practicing physicians regarding potentially detrimental behavioral…”
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Timing versus duration: determinants of anesthesia-induced developmental apoptosis in the young mammalian brain by Rizzi, Sabina, Ori, Carlo, Jevtovic-Todorovic, Vesna

“…Rapidly accumulating evidence indicates that clinically used general anesthesia causes massive, widespread neuroapoptotic degeneration in the developing…”
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Functional Implications of an Early Exposure to General Anesthesia: Are We Changing the Behavior of Our Children? by Jevtovic-Todorovic, Vesna

“…There is a rapidly growing body of animal and clinical evidence suggesting that the exposure to anesthetics and sedatives during the critical stages of brain…”
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T‐type voltage‐gated calcium channels as targets for the development of novel pain therapies by Todorovic, Slobodan M, Jevtovic‐Todorovic, Vesna

“…It is well recognized that voltage‐gated calcium (Ca2+) channels modulate the function of peripheral and central pain pathways by influencing fast synaptic…”
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Timing versus duration by Rizzi, Sabina, Ori, Carlo, Jevtovic-Todorovic, Vesna

“…Rapidly accumulating evidence indicates that clinically used general anesthesia causes massive, widespread neuroapoptotic degeneration in the developing…”
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Developmental synaptogenesis and general anesthesia: a kiss of death? by Jevtovic-Todorovic, Vesna

“…Normal cognitive development depends on the timely formation of meaningful neuronal circuitries. These, in turn, depend on the proper formation and functioning…”
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Potent analgesic effects of anticonvulsants on peripheral thermal nociception in rats by Todorovic, Slobodan M, Rastogi, A J, Jevtovic‐Todorovic, Vesna

“…Anticonvulsant agents are commonly used to treat neuropathic pain conditions because of their effects on voltage‐ and ligand‐gated channels in central pain…”
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Do We Have Viable Protective Strategies against Anesthesia-Induced Developmental Neurotoxicity? by Useinovic, Nemanja, Maksimovic, Stefan, Near, Michelle, Quillinan, Nidia, Jevtovic-Todorovic, Vesna

“…Since its invention, general anesthesia has been an indispensable component of modern surgery. While traditionally considered safe and beneficial in many…”
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Neonatal ketamine exposure impairs infrapyramidal bundle pruning and causes lasting increase in excitatory synaptic transmission in hippocampal CA3 neurons by Cabrera, Omar Hoseá, Useinovic, Nemanja, Maksimovic, Stefan, Near, Michelle, Quillinan, Nidia, Todorovic, Slobodan M., Jevtovic-Todorovic, Vesna

“…Preclinical models demonstrate that nearly all anesthetics cause widespread neuroapoptosis in the developing brains of infant rodents and non-human primates…”
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The Role of Neuroactive Steroids in Analgesia and Anesthesia: An Interesting Comeback? by Jevtovic-Todorovic, Vesna, Todorovic, Slobodan M

“…Published evidence over the past few decades suggests that general anesthetics could be neurotoxins especially when administered at the extremes of age. The…”
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Early Exposure to General Anesthesia Disturbs Mitochondrial Fission and Fusion in the Developing Rat Brain by BOSCOLO, Annalisa, MILANOVIC, Desanka, STARR, John A, SANCHEZ, Victoria, OKLOPCIC, Azra, MOY, Laurie, ORI, Carlo, ERISIR, Alev, JEVTOVIC-TODOROVIC, Vesna

“…General anesthetics induce apoptotic neurodegeneration in the developing mammalian brain. General anesthesia (GA) also causes significant disturbances in…”
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General Anesthesia Causes Long-term Impairment of Mitochondrial Morphogenesis and Synaptic Transmission in Developing Rat Brain by SANCHEZ, Victoria, FEINSTEIN, Shawn D, LUNARDI, Nadia, JOKSOVIC, Pavle M, BOSCOLO, Annalisa, TODOROVIC, Slobodan M, JEVTOVIC-TODOROVIC, Vesna

“…Clinically used general anesthetics, alone or in combination, are damaging to the developing mammalian brain. In addition to causing widespread apoptotic…”
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The Role of Free Oxygen Radicals in Lasting Hyperexcitability of Rat Subicular Neurons After Exposure to General Anesthesia During Brain Development by Joksimovic, Srdjan M., DiGruccio, Michael R., Boscolo, Annalisa, Jevtovic-Todorovic, Vesna, Todorovic, Slobodan M.

“…A large number of preclinical studies have established that general anesthetics (GAs) may cause neurodevelopmental toxicity in rodents and nonhuman primates,…”
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General Anesthesia and the Young Brain: The Importance of Novel Strategies with Alternate Mechanisms of Action by Maksimovic, Stefan, Useinovic, Nemanja, Quillinan, Nidia, Covey, Douglas F, Todorovic, Slobodan M, Jevtovic-Todorovic, Vesna

“…Over the past three decades, we have been grappling with rapidly accumulating evidence that general anesthetics (GAs) may not be as innocuous for the young…”
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