Particle interactions of fluticasone propionate and salmeterol xinafoate detected with single particle aerosol mass spectrometry (SPAMS)

[Display omitted] Particle co-associations between the active pharmaceutical ingredients fluticasone propionate and salmeterol xinafoate were examined in dry powder inhaled (DPI) and metered dose inhaled (MDI) combination products. Single Particle Aerosol Mass Spectrometry was used to investigate th...

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Bibliographic Details
Published in:	International journal of pharmaceutics Vol. 532; no. 1; pp. 218 - 228
Main Authors:	Jetzer, Martin W., Morrical, Bradley D., Fergenson, David P., Imanidis, Georgios
Format:	Journal Article
Language:	English
Published:	Netherlands Elsevier B.V 30-10-2017
Subjects:	Adrenergic beta-2 Receptor Agonists - chemistry Aerosols Bronchodilator Agents - chemistry Dry powder inhaler (DPI) Dry Powder Inhalers Fluticasone-Salmeterol Drug Combination - chemistry Glucocorticoids - chemistry Mass Spectrometry Metered Dose Inhalers Particle Co-associations Particle interactions Pressurized metered dose inhaler (pMDI) Single particle aerosol mass spectrometry (SPAMS) Pressurized metered dose inhaler (pMDI) Single particle aerosol mass spectrometry (SPAMS) Particle interactions Particle Co-associations Dry powder inhaler (DPI)
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Summary:	[Display omitted] Particle co-associations between the active pharmaceutical ingredients fluticasone propionate and salmeterol xinafoate were examined in dry powder inhaled (DPI) and metered dose inhaled (MDI) combination products. Single Particle Aerosol Mass Spectrometry was used to investigate the particle interactions in Advair Diskus® (500/50 mcg) and Seretide® (125/25 mcg). A simple rules tree was used to identify each compound, either alone or co-associated at the level of the individual particle, using unique marker peaks in the mass spectra for the identification of each drug. High levels of drug particle co-association (fluticasone-salmeterol) were observed in the aerosols emitted from Advair Diskus® and Seretide®. The majority of the detected salmeterol particles were found to be in co-association with fluticasone in both tested devices. Another significant finding was that rather coarse fluticasone particles (in DPI) and fine salmeterol particles (both MDI and DPI) were forming the particle co-associations.
Bibliography:	ObjectType-Article-1 SourceType-Scholarly Journals-1 ObjectType-Feature-2 content type line 23
ISSN:	0378-5173 1873-3476
DOI:	10.1016/j.ijpharm.2017.08.113