Search Results - "Jetten, Marlon J. A."

Interindividual variation in gene expression responses and metabolite formation in acetaminophen-exposed primary human hepatocytes by Jetten, Marlon J. A., Ruiz-Aracama, Ainhoa, Coonen, Maarten L. J., Claessen, Sandra M., van Herwijnen, Marcel H. M., Lommen, Arjen, van Delft, Joost H. M., Peijnenburg, Ad A. C. M., Kleinjans, Jos C. S.

“…Acetaminophen (APAP) is a readily available over-the-counter drug and is one of the most commonly used analgesics/antipyretics worldwide. Large interindividual…”
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diXa: a data infrastructure for chemical safety assessment by Hendrickx, Diana M, Aerts, Hugo J W L, Caiment, Florian, Clark, Dominic, Ebbels, Timothy M D, Evelo, Chris T, Gmuender, Hans, Hebels, Dennie G A J, Herwig, Ralf, Hescheler, Jürgen, Jennen, Danyel G J, Jetten, Marlon J A, Kanterakis, Stathis, Keun, Hector C, Matser, Vera, Overington, John P, Pilicheva, Ekaterina, Sarkans, Ugis, Segura-Lepe, Marcelo P, Sotiriadou, Isaia, Wittenberger, Timo, Wittwehr, Clemens, Zanzi, Antonella, Kleinjans, Jos C S

“…The field of toxicogenomics (the application of '-omics' technologies to risk assessment of compound toxicities) has expanded in the last decade, partly driven…”
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Omics analysis of low dose acetaminophen intake demonstrates novel response pathways in humans by Jetten, Marlon J.A., Gaj, Stan, Ruiz-Aracama, Ainhoa, de Kok, Theo M., van Delft, Joost H.M., Lommen, Arjen, van Someren, Eugene P., Jennen, Danyel G.J., Claessen, Sandra M., Peijnenburg, Ad A.C.M., Stierum, Rob H., Kleinjans, Jos C.S.

“…Acetaminophen is the primary cause of acute liver toxicity in Europe/USA, which led the FDA to reconsider recommendations concerning safe acetaminophen…”
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Interindividual variation in response to xenobiotic exposure established in precision-cut human liver slices by Jetten, Marlon J.A, Claessen, Sandra M, Dejong, Cornelis H.C, Lahoz, Agustin, Castell, José V, van Delft, Joost H.M, Kleinjans, Jos C.S

“…Highlights • Interindividual variation in GE/EA mostly exceeds variation in phenotypical endpoints. • Baseline CYP levels correlate to several response…”
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Evidence of female-specific glial deficits in the hippocampus in a mouse model of prenatal stress by Behan, Áine T, van den Hove, Daniel L.A, Mueller, Lynn, Jetten, Marlon J.A, Steinbusch, Harry W.M, Cotter, David R, Prickaerts, Jos

“…Abstract Prenatal stress (PS) has been associated with an increased incidence of numerous neuropsychiatric disorders, including depression, anxiety,…”
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Evaluation of database-derived pathway development for enabling biomarker discovery for hepatotoxicity by Hebels, Dennie G A, Jetten, Marlon J A, Aerts, Hugo J W, Herwig, Ralf, Theunissen, Daniël H J, Gaj, Stan, van Delft, Joost H, Kleinjans, Jos C S

“…Current testing models for predicting drug-induced liver injury are inadequate, as they basically under-report human health risks. We present here an approach…”
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