Search Results - "Jette, Claudia A."

SARS-CoV-2 neutralizing antibody structures inform therapeutic strategies by Barnes, Christopher O., Jette, Claudia A., Abernathy, Morgan E., Dam, Kim-Marie A., Esswein, Shannon R., Gristick, Harry B., Malyutin, Andrey G., Sharaf, Naima G., Huey-Tubman, Kathryn E., Lee, Yu E., Robbiani, Davide F., Nussenzweig, Michel C., West, Anthony P., Bjorkman, Pamela J.

“…The coronavirus disease 2019 (COVID-19) pandemic presents an urgent health crisis. Human neutralizing antibodies that target the host ACE2 receptor-binding…”
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Structural and functional analysis of mRNA export regulation by the nuclear pore complex by Lin, Daniel H., Correia, Ana R., Cai, Sarah W., Huber, Ferdinand M., Jette, Claudia A., Hoelz, André

“…The nuclear pore complex (NPC) controls the passage of macromolecules between the nucleus and cytoplasm, but how the NPC directly participates in…”
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Broad cross-reactivity across sarbecoviruses exhibited by a subset of COVID-19 donor-derived neutralizing antibodies by Jette, Claudia A., Cohen, Alexander A., Gnanapragasam, Priyanthi N.P., Muecksch, Frauke, Lee, Yu E., Huey-Tubman, Kathryn E., Schmidt, Fabian, Hatziioannou, Theodora, Bieniasz, Paul D., Nussenzweig, Michel C., West, Anthony P., Keeffe, Jennifer R., Bjorkman, Pamela J., Barnes, Christopher O.

“…Many anti-severe acute respiratory syndrome coronavirus 2 (anti-SARS-CoV-2) neutralizing antibodies target the angiotensin-converting enzyme 2 (ACE2) binding…”
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Cryo-EM structures of HIV-1 trimer bound to CD4-mimetics BNM-III-170 and M48U1 adopt a CD4-bound open conformation by Jette, Claudia A., Barnes, Christopher O., Kirk, Sharon M., Melillo, Bruno, Smith, Amos B., Bjorkman, Pamela J.

“…Human immunodeficiency virus-1 (HIV-1), the causative agent of AIDS, impacts millions of people. Entry into target cells is mediated by the HIV-1 envelope…”
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Geometric parameters that affect the behavior of logic-gated CAR T cells by Partin, Alexander C, Bruno, Richele, Shafaattalab, Sanam, Vander Mause, Erica, Winters, Aaron, Daris, Mark, Gahrs, Casey, Jette, Claudia A, DiAndreth, Breanna, Sandberg, Mark L, Hamburger, Agnes E, Kamb, Alexander, Riley, Timothy P

“…Clinical applications of CAR-T cells are limited by the scarcity of tumor-specific targets and are often afflicted with the same on-target/off-tumor toxicities…”
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How Antibodies Recognize Pathogenic Viruses: Structural Correlates of Antibody Neutralization of HIV-1, SARS-CoV-2, and Zika by Abernathy, Morgan E, Dam, Kim-Marie A, Esswein, Shannon R, Jette, Claudia A, Bjorkman, Pamela J

“…The H1N1 pandemic of 2009-2010, MERS epidemic of 2012, Ebola epidemics of 2013-2016 and 2018-2020, Zika epidemic of 2015-2016, and COVID-19 pandemic of…”
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Broad cross-reactivity across sarbecoviruses exhibited by a subset of COVID-19 donor-derived neutralizing antibodies by Jette, Claudia A., Cohen, Alexander A., Gnanapragasam, Priyanthi N.P., Muecksch, Frauke, Lee, Yu E., Huey-Tubman, Kathryn E., Schmidt, Fabian, Hatziioannou, Theodora, Bieniasz, Paul D., Nussenzweig, Michel C., West, Anthony P., Keeffe, Jennifer R., Bjorkman, Pamela J., Barnes, Christopher O.

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HLA-A∗02-gated safety switch for cancer therapy has exquisite specificity for its allelic target antigen by Mock, Jee-Young, Winters, Aaron, Riley, Timothy P., Bruno, Richele, Naradikian, Martin S., Sharma, Shruti, Jette, Claudia A., Elshimali, Ryan, Gahrs, Casey, Toledo-Warshaviak, Dora, West, Anthony P., Kamb, Alexander, Hamburger, Agnes E.

“…Innovative cell-based therapies are important new weapons in the fight against difficult-to-treat cancers. One promising strategy involves cell therapies…”
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Mosaic RBD nanoparticles protect against challenge by diverse sarbecoviruses in animal models by Cohen, Alexander A, van Doremalen, Neeltje, Greaney, Allison J, Andersen, Hanne, Sharma, Ankur, Starr, Tyler N, Keeffe, Jennifer R, Fan, Chengcheng, Schulz, Jonathan E, Gnanapragasam, Priyanthi N P, Kakutani, Leesa M, West, Jr, Anthony P, Saturday, Greg, Lee, Yu E, Gao, Han, Jette, Claudia A, Lewis, Mark G, Tan, Tiong K, Townsend, Alain R, Bloom, Jesse D, Munster, Vincent J, Bjorkman, Pamela J

“…To combat future severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) variants and spillovers of SARS-like betacoronaviruses (sarbecoviruses)…”
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Architecture of the cytoplasmic face of the nuclear pore by Bley, Christopher J, Nie, Si, Mobbs, George W, Petrovic, Stefan, Gres, Anna T, Liu, Xiaoyu, Mukherjee, Somnath, Harvey, Sho, Huber, Ferdinand M, Lin, Daniel H, Brown, Bonnie, Tang, Aaron W, Rundlet, Emily J, Correia, Ana R, Chen, Shane, Regmi, Saroj G, Stevens, Taylor A, Jette, Claudia A, Dasso, Mary, Patke, Alina, Palazzo, Alexander F, Kossiakoff, Anthony A, Hoelz, André

“…INTRODUCTION The subcellular compartmentalization of eukaryotic cells requires selective transport of folded proteins and protein-nucleic acid complexes…”
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Staged induction of HIV-1 glycan-dependent broadly neutralizing antibodies by Bonsignori, Mattia, Kreider, Edward F, Fera, Daniela, Meyerhoff, R Ryan, Bradley, Todd, Wiehe, Kevin, Alam, S Munir, Aussedat, Baptiste, Walkowicz, William E, Hwang, Kwan-Ki, Saunders, Kevin O, Zhang, Ruijun, Gladden, Morgan A, Monroe, Anthony, Kumar, Amit, Xia, Shi-Mao, Cooper, Melissa, Louder, Mark K, McKee, Krisha, Bailer, Robert T, Pier, Brendan W, Jette, Claudia A, Kelsoe, Garnett, Williams, Wilton B, Morris, Lynn, Kappes, John, Wagh, Kshitij, Kamanga, Gift, Cohen, Myron S, Hraber, Peter T, Montefiori, David C, Trama, Ashley, Liao, Hua-Xin, Kepler, Thomas B, Moody, M Anthony, Gao, Feng, Danishefsky, Samuel J, Mascola, John R, Shaw, George M, Hahn, Beatrice H, Harrison, Stephen C, Korber, Bette T, Haynes, Barton F

“…A preventive HIV-1 vaccine should induce HIV-1-specific broadly neutralizing antibodies (bnAbs). However, bnAbs generally require high levels of somatic…”
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Author Correction: SARS-CoV-2 neutralizing antibody structures inform therapeutic strategies by Barnes, Christopher O., Jette, Claudia A., Abernathy, Morgan E., Dam, Kim-Marie A., Esswein, Shannon R., Gristick, Harry B., Malyutin, Andrey G., Sharaf, Naima G., Huey-Tubman, Kathryn E., Lee, Yu E., Robbiani, Davide F., Nussenzweig, Michel C., West, Anthony P., Bjorkman, Pamela J.

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Structural and functional analysis of mRNA export regulation by the nuclear pore complex by Lin, Daniel H., Correia, Ana R., Cai, Sarah W., Huber, Ferdinand M., Jette, Claudia A., Hoelz, André

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