Effect of a bed covering system in children with asthma and house dust mite hypersensitivity

Allergen avoidance is regarded as an important approach to management of atopic asthma. The effect of Intervent bed covering systems on house dust mite (HDM) allergen exposure, asthma symptoms and markers of inflammation was investigated in 31 HDM sensitive asthmatic children. Dust concentrations of...

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Bibliographic Details
Published in:	The European respiratory journal Vol. 10; no. 2; pp. 361 - 366
Main Authors:	Frederick, JM, Warner, JO, Jessop, WJ, Enander, I, Warner, JA
Format:	Journal Article
Language:	English
Published:	Leeds Eur Respiratory Soc 01-02-1997 Maney
Subjects:	Adolescent Allergens Allergic diseases Animals Antigens, Dermatophagoides Asthma - blood Asthma - physiopathology Asthma - therapy Bedding and Linens Biological and medical sciences Blood Proteins - analysis Bronchial Hyperreactivity Bronchial Provocation Tests Child Child, Preschool Cross-Over Studies Dust - analysis Eosinophil Granule Proteins Eosinophil Peroxidase Eosinophil-Derived Neurotoxin Eosinophils Female Glycoproteins - analysis Histamine Humans Immunopathology Inflammation Mediators - analysis Male Medical sciences Mites Peak Expiratory Flow Rate Peroxidases - analysis Receptors, Interleukin-2 - blood Respiratory and ent allergic diseases Respiratory Hypersensitivity - blood Respiratory Hypersensitivity - physiopathology Respiratory Hypersensitivity - therapy Ribonucleases Single-Blind Method Allergy Mattress Acari Obstructive pulmonary disease Child Human Immunopathology Respiratory disease Treatment efficiency Maximum expiratory flow rate Acaridida Instrumentation therapy Exploration Coverage Concentration Dermatophagoides pteronyssinus Asthma Lung volume Acariformes Arachnida Dust Treatment Arthropoda Pyroglyphidae Invertebrata Allergen
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Summary:	Allergen avoidance is regarded as an important approach to management of atopic asthma. The effect of Intervent bed covering systems on house dust mite (HDM) allergen exposure, asthma symptoms and markers of inflammation was investigated in 31 HDM sensitive asthmatic children. Dust concentrations of Dermatophagoides pteronyssinus allergen 1 (Der p 1) were monitored before and after covering the mattress, duvet and pillow with active and placebo covers for 3 months, in a single-blind, cross-over trial. Twice daily peak expiratory flow rate (PEFR), daily symptom scores and treatment schedule were recorded. Bronchial hyperresponsiveness was monitored by histamine challenge (provocative concentration of histamine causing a 20% fall in forced expiratory volume in one second (PC20)), and inflammation by measuring eosinophil cationic protein (ECP), eosinophil protein X (EPX), eosinophil peroxidase (EPO), and soluble interleukin-2 receptor (sIL-2R) in serum. There was a significant reduction in Der p 1 when the mattress, duvet and pillow were covered with the active bedding. There was no significant improvement in symptoms of asthma, PEFR, bronchodilator usage of PC20. Also, ECP, EPX, sIL-2R concentrations did not change for either treatment. EPO concentrations were significantly lower in the active compared to the placebo period. The active bed covers reduced retrievable Dermatophagoides pteronyssinus allergen 1 (Der p 1) from the bedding, with short term clinical benefit.
ISSN:	0903-1936 1399-3003
DOI:	10.1183/09031936.97.10020361