Search Results - "Jessica K. Bell"

Length of course-based undergraduate research experiences (CURE) impacts student learning and attitudinal outcomes: A study of the Malate dehydrogenase CUREs Community (MCC) by DeChenne-Peters, Sue Ellen, Rakus, John F, Parente, Amy D, Mans, Tamara L, Eddy, Rebecca, Galport, Nicole, Koletar, Courtney, Provost, Joseph J, Bell, J Ellis, Bell, Jessica K

“…Course-based undergraduate research experiences (CUREs) are laboratory courses that integrate broadly relevant problems, discovery, use of the scientific…”
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TLR3 signaling complex forms by cooperative receptor dimerization by Leonard, Joshua N, Ghirlando, Rodolfo, Askins, Janine, Bell, Jessica K, Margulies, David H, Davies, David R, Segal, David M

“…Toll-like receptors (TLRs) initiate immune responses by recognizing pathogen-associated molecules, but the molecular basis for recognition is poorly…”
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The DsRNA Binding Site of Human Toll-Like Receptor 3 by Bell, Jessica K., Askins, Janine, Hall, Pamela R., Davies, David R., Segal, David M.

“…Pathogen recognition by Toll-like receptors (TLRs) initiates innate immune responses that are essential for inhibiting pathogen dissemination and for the…”
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The Molecular Structure of the Toll-Like Receptor 3 Ligand-Binding Domain by Bell, Jessica K., Botos, Istvan, Hall, Pamela R., Askins, Janine, Shiloach, Joseph, Segal, David M., Davies, David R.

“…Innate immunity is the first line of defense against invading pathogens. Toll-like receptors (TLRs) act as sentinels of the innate immune system, sensing a…”
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Leucine-rich repeats and pathogen recognition in Toll-like receptors by Bell, Jessica K., Mullen, Gregory E.D., Leifer, Cynthia A., Mazzoni, Alessandra, Davies, David R., Segal, David M.

“…Toll-like receptors (TLRs) are the major cell-surface initiators of inflammatory responses to pathogens. They bind a wide variety of pathogenic substances…”
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Innate immune agonist, dsRNA, induces apoptosis in ovarian cancer cells and enhances the potency of cytotoxic chemotherapeutics by Van, Danielle N., Roberts, Charlotte F., Marion, James D., Lépine, Sandrine, Harikumar, Kuzhuvelil B., Schreiter, Jessica, Dumur, Catherine I., Fang, Xianjun, Spiegel, Sarah, Bell, Jessica K.

“…ABSTRACT Ovarian cancer is the most lethal gynecological cancer. Here we show that innate immune agonist, dsRNA, directly induces ovarian cancer cell death and…”
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Lateral Clustering of TLR3:dsRNA Signaling Units Revealed by TLR3ecd:3Fabs Quaternary Structure by Luo, Jinquan, Obmolova, Galina, Malia, Thomas J., Wu, Sheng-Jiun, Duffy, Karen E., Marion, James D., Bell, Jessica K., Ge, Peng, Zhou, Z. Hong, Teplyakov, Alexey, Zhao, Yonghong, Lamb, Roberta J., Jordan, Jarrat L., San Mateo, Lani R., Sweet, Raymond W., Gilliland, Gary L.

“…Toll-like receptor 3 (TLR3) recognizes dsRNA and initiates an innate immune response through the formation of a signaling unit (SU) composed of one…”
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The TOLL of inflammation in multiple myeloma by Bell, Jessica K.

“…Commentary to: Triggering of toll-like receptor-4 in human multiple myeloma cells promotes proliferation and alters cell responses to immune and chemotherapy…”
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Vmax Regulation through Domain and Subunit Changes. The Active Form of Phosphoglycerate Dehydrogenase by THOMPSON, James R., BELL, Jessica K., BRATT, Judy, GRANT, Gregory A., BANASZAK, Leonard J.

“…An active conformation of phosphoglycerate dehydrogenase (PGDH) from Escherichia coli has been obtained using X-ray crystallography. The X-ray crystal…”
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SIKE’s Phosphorylation Sites Alter Quaternary Structure by Etiel, Daniel, Pham, Alyssa, Ryu, Sally, Lyons, Cade, Dzotsi, Marissa, Patel, Diya, Nguyen, Thereasa, McCool, Ryan S., Bell, Jessica K.

“…Protein‐protein interactions (PPIs) are a crucial part of intracellular communication and function. The “rules” for specificity and/or selection of a…”
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Predicting Toll-like receptor structures and characterizing ligand binding by Leonard, Joshua N, Bell, Jessica K, Segal, David M

“…Toll-like receptor (TLR) ligand-binding domains comprise 18-25 tandem copies of a 24-residue motif known as the leucine-rich repeat (LRR). Unlike other LRR…”
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Student Outcomes Differ Based on Length of a Course‐based Undergraduate Research Experience (CURE) by Bell, Jessica K., DeChenne‐Peters, Sue Ellen, Rakus, John, Parente, Amy, Mans, Tamara L., Eddy, Rebecca, Galport, Nicole, Koletar, Courtney, Provost, Joseph J., Bell, John E.

“…Course‐based Undergraduate Research Experiences (CUREs) offer an inclusive means to engage students in the scientific process and enhance student learning…”
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External Collaboration Results in Student Learning Gains and Positive STEM Attitudes in CUREs by Callahan, Kevin P, Peterson, Celeste N, Martinez-Vaz, Betsy M, Huisinga, Kathryn L, Galport, Nicole, Koletar, Courtney, Eddy, Rebecca M, Provost, Joseph J, Bell, Jessica K, Bell, Ellis

“…The implementation of course-based undergraduate research experiences (CUREs) has made it possible to expose large undergraduate populations to research…”
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CUREs in biochemistry—where we are and where we should go by Bell, Jessica K., Eckdahl, Todd T., Hecht, David A., Killion, Patrick J., Latzer, Joachim, Mans, Tamara L., Provost, Joseph J., Rakus, John F., Siebrasse, Erica A., Ellis Bell, J.

“…Integration of research experience into classroom is an important and vital experience for all undergraduates. These course‐based undergraduate research…”
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Moving biochemistry and molecular biology courses online in times of disruption: Recommended practices and resources ‐ a collaboration with the faculty community and ASBMB by Procko, Kristen, Bell, Jessica K., Benore, Marilee A., Booth, Rachell E., Del Gaizo Moore, Victoria, Dries, Daniel R., Martin, Debra J., Mertz, Pamela S., Offerdahl, Erika G., Payne, Marvin A., Vega, Quinn C., Provost, Joseph J.

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Predicting and validating a model of suppressor of IKKepsilon through biophysical characterization by Machek, Megan L., Sonnenschein, Halie A., Graham, Sasha‐Kaye I., Shikwana, Flowreen, Kim, Seung‐Hwan L., Garcia DuBar, Selena, Minzer, Ian D., Wey, Ryan, Bell, Jessica K.

“…Suppressor of IKKepsilon (SIKE) is a 207 residue protein that is implicated in the TLR3‐TANK‐binding kinase‐1‐mediated response to viral infection. SIKE's…”
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Cyclic-di-GMP binding induces structural rearrangements in the PlzA and PlzC proteins of the Lyme disease and relapsing fever spirochetes: a possible switch mechanism for c-di-GMP-mediated effector functions by Mallory, Katherine L., Miller, Daniel P., Oliver, Lee D., Freedman, John C., Kostick-Dunn, Jessica L., Carlyon, Jason A., Marion, James D., Bell, Jessica K., Marconi, Richard T.

“…The c-di-GMP network of Borrelia burgdorferi, a causative agent of Lyme disease, consists of Rrp1, a diguanylate cyclase/response regulator; Hpk1, a histidine…”
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Structure of factor H-binding protein B (FhbB) of the periopathogen, Treponema denticola: insights into progression of periodontal disease by Miller, Daniel P, Bell, Jessica K, McDowell, John V, Conrad, Daniel H, Burgner, John W, Héroux, Annie, Marconi, Richard T

“…Periodontitis is the most common disease of microbial etiology in humans. Periopathogen survival is dependent upon evasion of complement-mediated destruction…”
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Mechanism of Endogenous Regulation of the Type I Interferon Response by Suppressor of IκB Kinase ϵ (SIKE), a Novel Substrate of TANK-binding Kinase 1 (TBK1) by Marion, James D., Roberts, Charlotte F., Call, R. Jason, Forbes, Jonathan L., Nelson, Kristina T., Bell, J. Ellis, Bell, Jessica K.

“…TANK-binding kinase 1 (TBK1) serves as a key convergence point in multiple innate immune signaling pathways. In response to receptor-mediated pathogen…”
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Homology model and targeted mutagenesis identify critical residues for arachidonic acid inhibition of Kv4 channels by Heler, Robert, Bell, Jessica K., Boland, Linda M.

“…Polyunsaturated fatty acids such as arachidonic acid (AA) exhibit inhibitory modulation of Kv4 potassium channels. Molecular docking approaches using a Kv4.2…”
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