Search Results - "Jessen, Walter J."

MEK inhibition exhibits efficacy in human and mouse neurofibromatosis tumors by Jessen, Walter J, Miller, Shyra J, Jousma, Edwin, Wu, Jianqiang, Rizvi, Tilat A, Brundage, Meghan E, Eaves, David, Widemann, Brigitte, Kim, Mi-Ok, Dombi, Eva, Sabo, Jessica, Hardiman Dudley, Atira, Niwa-Kawakita, Michiko, Page, Grier P, Giovannini, Marco, Aronow, Bruce J, Cripe, Timothy P, Ratner, Nancy

“…Neurofibromatosis type 1 (NF1) patients develop benign neurofibromas and malignant peripheral nerve sheath tumors (MPNST). These incurable peripheral nerve…”
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Insertional Mutagenesis Identifies a STAT3/Arid1b/β-catenin Pathway Driving Neurofibroma Initiation by Wu, Jianqiang, Keng, Vincent W., Patmore, Deanna M., Kendall, Jed J., Patel, Ami V., Jousma, Edwin, Jessen, Walter J., Choi, Kwangmin, Tschida, Barbara R., Silverstein, Kevin A.T., Fan, Danhua, Schwartz, Eric B., Fuchs, James R., Zou, Yuanshu, Kim, Mi-Ok, Dombi, Eva, Levy, David E., Huang, Gang, Cancelas, Jose A., Stemmer-Rachamimov, Anat O., Spinner, Robert J., Largaespada, David A., Ratner, Nancy

“…To identify genes and signaling pathways that initiate Neurofibromatosis type 1 (NF1) neurofibromas, we used unbiased insertional mutagenesis screening, mouse…”
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Prolonged exposure to reduced levels of androgen accelerates prostate cancer progression in Nkx3.1; pten mutant mice by BANACH-PETROSKY, Whitney, JESSEN, Walter J, OUYANG, Xuesong, HUI GAO, RAO, Jayashree, QUINN, John, ARONOW, Bruce J, ABATE-SHEN, Cory

“…In this report, we have investigated the relationship between androgen levels and prostate tumorigenesis in Nkx3.1; Pten mutant mice, a genetically engineered…”
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The SWI/SNF ATPase Brm Is a Gatekeeper of Proliferative Control in Prostate Cancer by HUI SHEN, POWERS, Nathan, ARONOW, Bruce J, ROSSON, Gary, WEISSMAN, Bernard, MUCHARDT, Christian, YANIV, Moshe, KNUDSEN, Karen E, SAINI, Nitin, COMSTOCK, Clay E. S, SHARMA, Ankur, WEAVER, Katherine, REVELO, Monica P, GERALD, William, WILLIAMS, Erin, JESSEN, Walter J

“…Factors that drive prostate cancer progression remain poorly defined, thus hindering the development of new therapeutic strategies. Disseminated tumors are…”
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Gene Expression Analysis Identifies Potential Biomarkers of Neurofibromatosis Type 1 Including Adrenomedullin by HUMMEL, Trent R, JESSEN, Walter J, SCHORRY, Elizabeth K, RATNER, Nancy, MILLER, Shyra J, KLUWE, Lan, MAUTNER, Victor F, WALLACE, Margaret R, LAZARO, Conxi, PAGE, Grier P, WORLEY, Paul F, ARONOW, Bruce J

“…Plexiform neurofibromas (pNF) are Schwann cell tumors found in a third of individuals with neurofibromatosis type 1 (NF1). pNF can undergo transformation to…”
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Bayesian hierarchical model for transcriptional module discovery by jointly modeling gene expression and ChIP-chip data by Liu, Xiangdong, Jessen, Walter J, Sivaganesan, Siva, Aronow, Bruce J, Medvedovic, Mario

“…Transcriptional modules (TM) consist of groups of co-regulated genes and transcription factors (TF) regulating their expression. Two high-throughput (HT)…”
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Editor's Note: Activator Protein-1 Transcription Factors Are Associated with Progression and Recurrence of Prostate Cancer by Ouyang, Xuesong, Jessen, Walter J, Al-Ahmadie, Hikmat, Serio, Angel M, Lin, Yong, Shih, Weichung-Joseph, Reuter, Victor E, Scardino, Peter T, Shen, Michael M, Aronow, Bruce J, Vickers, Andrew J, Gerald, William L, Abate-Shen, Cory

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Global methylation profiles in buccal cells of long-term smokers and moist snuff consumers by Jessen, Walter J., Borgerding, Michael F., Prasad, G. L.

“…Purpose: Alternations in gene methylation and other epigenetic changes regulate normal development as well as drive disease progression. The aim of this study…”
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PTEN and NF1 Inactivation in Schwann Cells Produces a Severe Phenotype in the Peripheral Nervous System That Promotes the Development and Malignant Progression of Peripheral Nerve Sheath Tumors by KENG, Vincent W, RAHRMANN, Eric P, WATSON, Adrienne L, TSCHIDA, Barbara R, MOERTEL, Christopher L, JESSEN, Walter J, RIZVI, Tilat A, COLLINS, Margaret H, RATNER, Nancy, LARGAESPADA, David A

“…The genetic evolution from a benign neurofibroma to a malignant sarcoma in patients with neurofibromatosis type 1 (NF1) syndrome remains unclear. Schwann cells…”
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Ras-Driven Transcriptome Analysis Identifies Aurora Kinase A as a Potential Malignant Peripheral Nerve Sheath Tumor Therapeutic Target by PATEL, Ami V, EAVES, David, MILLER, Shyra J, RATNER, Nancy, JESSEN, Walter J, RIZVI, Tilat A, ECSEDY, Jeffrey A, QIAN, Mark G, ARONOW, Bruce J, PERENTESIS, John P, SERRA, Eduard, CRIPE, Timothy P

“…Patients with neurofibromatosis type 1 (NF1) develop malignant peripheral nerve sheath tumors (MPNST), which are often inoperable and do not respond well to…”
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Targeted Cytosine Methylation for in vivo Detection of Protein-DNA Interactions by Carvin, Christopher D., Dhasarathy, Archana, Friesenhahn, Laurie B., Jessen, Walter J., Kladde, Michael P.

“…We report a technique, named targeted gene methylation (TAGM), for identifying in vivo protein-binding sites in chromatin. M.CviPI, a cytosine-5 DNA…”
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Therapeutic Potential of HSP90 Inhibition for Neurofibromatosis Type 2 by TANAKA, Karo, ESKIN, Ascia, NELSON, Stanley F, RUBENSTEIN, Allan E, GIOVANNINI, Marco, CHAREYRE, Fabrice, JESSEN, Walter J, MANENT, Jan, NIWA-KAWAKITA, Michiko, RUIHONG CHEN, WHITE, Cory H, VITTE, Jeremie, JAFFER, Zahara M

“…The growth and survival of neurofibromatosis type 2 (NF2)-deficient cells are enhanced by the activation of multiple signaling pathways including…”
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Activator Protein-1 Transcription Factors Are Associated with Progression and Recurrence of Prostate Cancer by XUESONG OUYANG, JESSEN, Walter J, VICKERS, Andrew J, GERALD, William L, ABATE-SHEN, Cory, AL-AHMADIE, Hikmat, SERIO, Angel M, YONG LIN, SHIH, Weichung-Joseph, REUTER, Victor E, SCARDINO, Peter T, SHEN, Michael M, ARONOW, Bruce J

“…To identify biomarkers that discriminate the aggressive forms of prostate cancer, we performed gene expression profiling of prostate tumors using a genetically…”
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Cxcr3-expressing leukocytes are necessary for neurofibroma formation in mice by Fletcher, Jonathan S, Wu, Jianqiang, Jessen, Walter J, Pundavela, Jay, Miller, Jacob A, Dombi, Eva, Kim, Mi-Ok, Rizvi, Tilat A, Chetal, Kashish, Salomonis, Nathan, Ratner, Nancy

“…Plexiform neurofibroma is a major contributor to morbidity in patients with neurofibromatosis type I (NF1). Macrophages and mast cells infiltrate neurofibroma,…”
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Integrative genomic analyses of neurofibromatosis tumours identify SOX9 as a biomarker and survival gene by Miller, Shyra J., Jessen, Walter J., Mehta, Tapan, Hardiman, Atira, Sites, Emily, Kaiser, Sergio, Jegga, Anil G., Li, Hua, Upadhyaya, Meena, Giovannini, Marco, Muir, David, Wallace, Margaret R., Lopez, Eva, Serra, Eduard, Nielsen, G. Petur, Lazaro, Conxi, Stemmer‐Rachamimov, Anat, Page, Grier, Aronow, Bruce J., Ratner, Nancy

“…Understanding the biological pathways critical for common neurofibromatosis type 1 (NF1) peripheral nerve tumours is essential, as there is a lack of tumour…”
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Cyclin D1 Is a Selective Modifier of Androgen-dependent Signaling and Androgen Receptor Function by Comstock, Clay E.S., Augello, Michael A., Schiewer, Matthew J., Karch, Jason, Burd, Craig J., Ertel, Adam, Knudsen, Erik S., Jessen, Walter J., Aronow, Bruce J., Knudsen, Karen E.

“…D-type cyclins regulate cellular outcomes in part through cyclin-dependent, kinase-independent mechanisms that modify transcription factor action, and recent…”
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Active PHO5 chromatin encompasses variable numbers of nucleosomes at individual promoters by Kladde, Michael P, Jessen, Walter J, Hoose, Scott A, Kilgore, Jessica A

“…Transcriptional activation is often associated with chromatin remodeling. However, little is known about the dynamics of remodeling of nucleosome arrays in…”
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Mapping chromatin structure in vivo using DNA methyltransferases by Jessen, Walter J, Dhasarathy, Archana, Hoose, Scott A, Carvin, Christopher D, Risinger, April L, Kladde, Michael P

“…Cytosine-5 DNA methyltransferases (C5 DMTases) are effective reagents for analyzing chromatin and footprinting DNA-bound factors in vivo. Cytosine methylation…”
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Transcriptional recapitulation and subversion of embryonic colon development by mouse colon tumor models and human colon cancer by Kaiser, Sergio, Park, Young-Kyu, Franklin, Jeffrey L, Halberg, Richard B, Yu, Ming, Jessen, Walter J, Freudenberg, Johannes, Chen, Xiaodi, Haigis, Kevin, Jegga, Anil G, Kong, Sue, Sakthivel, Bhuvaneswari, Xu, Huan, Reichling, Timothy, Azhar, Mohammad, Boivin, Gregory P, Roberts, Reade B, Bissahoyo, Anika C, Gonzales, Fausto, Bloom, Greg C, Eschrich, Steven, Carter, Scott L, Aronow, Jeremy E, Kleimeyer, John, Kleimeyer, Michael, Ramaswamy, Vivek, Settle, Stephen H, Boone, Braden, Levy, Shawn, Graff, Jonathan M, Doetschman, Thomas, Groden, Joanna, Dove, William F, Threadgill, David W, Yeatman, Timothy J, Coffey, Jr, Robert J, Aronow, Bruce J

“…The expression of carcino-embryonic antigen by colorectal cancer is an example of oncogenic activation of embryonic gene expression. Hypothesizing that…”
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