Search Results - "Jessel, Sönke"

The urinary metabolites of DINCH® have an impact on the activities of the human nuclear receptors ERα, ERβ, AR, PPARα and PPARγ by Engel, Anika, Buhrke, Thorsten, Kasper, Stefanie, Behr, Anne-Cathrin, Braeuning, Albert, Jessel, Sönke, Seidel, Albrecht, Völkel, Wolfgang, Lampen, Alfonso

“…•DINCH® does not activate the human hormone receptors ERα, ERβ and AR.•DINCH® metabolites stimulate ERα,ERβ and AR activity.•DINCH® metabolites activate the…”
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Urinary Excretion of Mercapturic Acids of the Rodent Carcinogen Methyleugenol after a Single Meal of Basil Pesto: A Controlled Exposure Study in Humans by Nieschalke, Kai, Bergau, Nick, Jessel, Sönke, Seidel, Albrecht, Baldermann, Susanne, Schreiner, Monika, Abraham, Klaus, Lampen, Alfonso, Monien, Bernhard H., Kleuser, Burkhard, Glatt, Hansruedi, Schumacher, Fabian

“…Methyleugenol (ME), found in numerous plants and spices, is a rodent carcinogen and is classified as “possibly carcinogenic to humans”. The hypothesis of a…”
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Four selected high molecular weight heterocyclic aromatic hydrocarbons: Ecotoxicological hazard assessment, environmental relevance and regulatory needs under REACH by Brendel, Stephan, Polleichtner, Christian, Behnke, Andreas, Jessel, Sönke, Hassold, Enken, Jennemann, Christian, Einhenkel-Arle, Doreen, Seidel, Albrecht

“…Little is known about the ecotoxicity of heterocyclic aromatic hydrocarbons (NSO-HETs) to aquatic organisms. In the environment, NSO-HETs have been shown to…”
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Mizoroki-Heck Reactions with 4-Phenoldiazonium Salts by Schmidt, Bernd, Hölter, Frank, Berger, René, Jessel, Sönke

“…Significantly better yields were achieved in Mizoroki–Heck reactions using 4‐phenoldiazonium salts instead of their O‐alkylated analogues under otherwise…”
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Urinary toxicokinetics of di-(isononyl)-cyclohexane-1,2-dicarboxylate (DINCH®) in humans following single oral administration by Völkel, Wolfgang, Kiranoglu, Mandy, Dettbarn, Gerhard, John, Andrea, Jessel, Sönke, Seidel, Albrecht, Fromme, Hermann

“…•DINCH® at a dose of 1mg/kg b.w. is almost completely bioavailable in humans.•No significant sex differences between males and females were observed.•Only…”
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Synthesis of 2′,3′-Modified Carbocyclic L-Nucleoside Analogues by Jessel, Sönke, Meier, Chris

“…New divergent approaches to 2′,3′‐modified carbocyclic L‐nucleoside analogues starting from enantiomerically pure (1R,2S)‐ or…”
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Agonistic and antagonistic effects of phthalates and their urinary metabolites on the steroid hormone receptors ERα, ERβ, and AR by Engel, Anika, Buhrke, Thorsten, Imber, Francine, Jessel, Sönke, Seidel, Albrecht, Völkel, Wolfgang, Lampen, Alfonso

“…•Phthalates affect the activity of the hormone receptors ERα, ERβ and AR.•Phthalate metabolites do not affect hormone receptor activity.•DEHP metabolites…”
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An isotope-dilution UPLC–MS/MS technique for the human biomonitoring of the internal exposure to glycidol via a valine adduct at the N-terminus of hemoglobin by Hielscher, Jan, Monien, Bernhard H., Abraham, Klaus, Jessel, Sönke, Seidel, Albrecht, Lampen, Alfonso

“…•The adduct N-(diHOPr)-valine in hemoglobin is a biomarker of glycidol exposure.•The fluorescein conjugate of N-(diHOPr)-valine is characterized by NMR…”
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Stereoselective Synthetic Strategy to Potentially Antiviral Active Carbocyclic l-Nucleosides and l-Nucleotides by Worthmann, Claudia, Jessel, Sönke, Balzarini, Jan, Meier, Chris

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Bis-cycloSal-d4T-monophosphates:  Drugs That Deliver Two Molecules of Bioactive Nucleotides by Ducho, Christian, Görbig, Ulf, Jessel, Sönke, Gisch, Nicolas, Balzarini, Jan, Meier, Chris

“…Bis-cycloSal-d4T-monophosphates have been synthesized as potentially anti-HIV active “dimeric” prodrugs of 2‘,3‘-dideoxy-2‘,3‘-didehydrothymidine monophosphate…”
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Bis- cyclo Sal-d4T-monophosphates:  Drugs That Deliver Two Molecules of Bioactive Nucleotides by Ducho, Christian, Görbig, Ulf, Jessel, Sönke, Gisch, Nicolas, Balzarini, Jan, Meier, Chris

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