The association of vitamin K status with lung function and disease in a general population

Introduction Matrix Gla protein (MGP) is an inhibitor of lung tissue calcification. The plasma level of dephosphorylated-uncarboxylated MGP (dp-ucMGP) is a biomarker of vitamin K status. The present study assessed whether lower vitamin K status (reflected by higher dp-ucMGP) was associated with lung...

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Published in:	ERJ open research Vol. 9; no. 5; p. 208
Main Authors:	Jespersen, Torkil, Kampmann, Freja Bach, Dantoft, Thomas Meinertz, Jørgensen, Niklas Rye, Kårhus, Line Lund, Madsen, Flemming, Linneberg, Allan, Thysen, Sanne Marie
Format:	Journal Article
Language:	English
Published:	European Respiratory Society 01-09-2023
Subjects:	Original
Online Access:	Get full text
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Summary:	Introduction Matrix Gla protein (MGP) is an inhibitor of lung tissue calcification. The plasma level of dephosphorylated-uncarboxylated MGP (dp-ucMGP) is a biomarker of vitamin K status. The present study assessed whether lower vitamin K status (reflected by higher dp-ucMGP) was associated with lung function and lung disease/symptoms. Methods A general population sample of 4092 individuals, aged 24 to 77 years, underwent a health examination including questionnaires, spirometry and measurements of plasma dp-ucMGP. Associations of dp-ucMGP with lung function and self-reported disease/symptoms were estimated using regression models adjusted for age, sex and height. Associations were expressed as β-estimates or odds ratios (ORs) per doubling in dp-ucMGP. Results Lower vitamin K status (higher dp-ucMGP) was associated with lower forced expiratory volume in 1 s (FEV 1 ) (98 mL; 95% CI: 54–141 mL) and lower forced vital capacity (FVC) (136 mL; 95% CI: 85–187 mL). Dp-ucMGP was not associated with the FEV 1 /FVC ratio (0.0 percentage points higher than the expected value; 95% CI: −1.0–1.0). Furthermore, lower vitamin K status was associated with COPD (OR 2.24, 95% CI: 1.53–3.27), wheezing (OR 1.81, 95% CI: 1.44–2.28) and asthma (OR 1.44, 95% CI: 1.12–1.83). Conclusion Lower vitamin K status was associated with lower ventilatory capacity (lower FEV 1 and FVC), and with higher risk of self-reported asthma, COPD and wheezing. Vitamin K status was not associated with airflow obstruction (FEV 1 /FVC ratio).
Bibliography:	ObjectType-Article-1 SourceType-Scholarly Journals-1 ObjectType-Feature-2 content type line 23
ISSN:	2312-0541 2312-0541
DOI:	10.1183/23120541.00208-2023