Search Results - "Jespersen, N R"
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Mitochondrial Function is Impaired in Heart Transplant Patients with Cardiac Allograft Vasculopathy
Published in The Journal of heart and lung transplantation (01-04-2020)“…Cardiac allograft vasculopathy (CAV) remains the Achilles’ heel of long-term survival of heart transplanted (HTx) patients. CAV affects approximately 50 % of…”
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Organ-specific responses during brain death: increased aerobic metabolism in the liver and anaerobic metabolism with decreased perfusion in the kidneys
Published in Scientific reports (13-03-2018)“…Hepatic and renal energy status prior to transplantation correlates with graft survival. However, effects of brain death (BD) on organ-specific energy status…”
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Inhibition of KV7 Channels Protects the Rat Heart against Myocardial Ischemia and Reperfusion Injury
Published in The Journal of pharmacology and experimental therapeutics (01-04-2016)“…The voltage-gated KV7 (KCNQ) potassium channels are activated by ischemia and involved in hypoxic vasodilatation. We investigated the effect of KV7 channel…”
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P3487Pre-ischemic succinate dehydrogenase inhibition is protective against ischemia-reperfusion injury in rat and human myocardium with and without diabetes mellitus
Published in European heart journal (01-10-2019)“…Abstract Background Ischemia-reperfusion (IR) injury can be attenuated through modulation of mitochondrial metabolism with succinate dehydrogenase (SDH)…”
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Impact of Administration Time and Kv7 Subchannels on the Cardioprotective Efficacy of Kv7 Channel Inhibition
Published in Drug design, development and therapy (01-01-2020)“…The mechanism of cardioprotection by Kv7.1-5 (KCNQ1-5) channels inhibition by XE991 is unclear. We examined the impact of administration time on the…”
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