Search Results - "Jesmond Dalli"

Specific lipid mediator signatures of human phagocytes: microparticles stimulate macrophage efferocytosis and pro-resolving mediators by Dalli, Jesmond, Serhan, Charles N.

“…Phagocytes orchestrate acute inflammation and host defense. Here we carried out lipid mediator (LM) metabololipidomics profiling distinct phagocytes:…”
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Identification and structure elucidation of the pro‐resolving mediators provides novel leads for resolution pharmacology by Dalli, Jesmond, Serhan, Charles N

“…Inflammatory diseases are a major socio‐economic burden, with the incidence of such conditions on the rise, especially in western societies. For decades, the…”
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The resolution code of acute inflammation: Novel pro-resolving lipid mediators in resolution by Serhan, Charles N, Chiang, Nan, Dalli, Jesmond

“…Highlights • Biosynthesis of specialized proresolving mediators (SPM). • Functions of resolvins, lipoxins, protectins and maresins. • SPM actions in animal…”
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Identification of resolvin D2 receptor mediating resolution of infections and organ protection by Chiang, Nan, Dalli, Jesmond, Colas, Romain A, Serhan, Charles N

“…Endogenous mechanisms that orchestrate resolution of acute inflammation are essential in host defense and the return to homeostasis. Resolvin (Rv)D2 is a…”
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Lipid mediators in the resolution of inflammation by Serhan, Charles N, Chiang, Nan, Dalli, Jesmond, Levy, Bruce D

“…Mounting of the acute inflammatory response is crucial for host defense and pivotal to the development of chronic inflammation, fibrosis, or abscess formation…”
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Pro-Resolving Mediators in Regulating and Conferring Macrophage Function by Dalli, Jesmond, Serhan, Charles N

“…Macrophages are central in coordinating the host response to both sterile and infective insults. Clearance of apoptotic cells and cellular debris is a key…”
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Resolvins suppress tumor growth and enhance cancer therapy by Sulciner, Megan L, Serhan, Charles N, Gilligan, Molly M, Mudge, Dayna K, Chang, Jaimie, Gartung, Allison, Lehner, Kristen A, Bielenberg, Diane R, Schmidt, Birgitta, Dalli, Jesmond, Greene, Emily R, Gus-Brautbar, Yael, Piwowarski, Julia, Mammoto, Tadanori, Zurakowski, David, Perretti, Mauro, Sukhatme, Vikas P, Kaipainen, Arja, Kieran, Mark W, Huang, Sui, Panigrahy, Dipak

“…Cancer therapy reduces tumor burden by killing tumor cells, yet it simultaneously creates tumor cell debris that may stimulate inflammation and tumor growth…”
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Vagal Regulation of Group 3 Innate Lymphoid Cells and the Immunoresolvent PCTR1 Controls Infection Resolution by Dalli, Jesmond, Colas, Romain A., Arnardottir, Hildur, Serhan, Charles N.

“…Uncovering mechanisms that control immune responses in the resolution of bacterial infections is critical for the development of new therapeutic strategies…”
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Protectins and maresins: New pro-resolving families of mediators in acute inflammation and resolution bioactive metabolome by Serhan, Charles N., Dalli, Jesmond, Colas, Romain A., Winkler, Jeremy W., Chiang, Nan

“…Acute inflammatory responses are protective, yet without timely resolution can lead to chronic inflammation and organ fibrosis. A systems approach to…”
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Reply to: Failure to apply standard limit-of-detection or limit-of-quantitation criteria to specialized pro-resolving mediator analysis incorrectly characterizes their presence in biological samples by Dalli, Jesmond, Gomez, Esteban A.

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Identification and signature profiles for pro-resolving and inflammatory lipid mediators in human tissue by Colas, Romain A, Shinohara, Masakazu, Dalli, Jesmond, Chiang, Nan, Serhan, Charles N

“…Resolution of acute inflammation is an active process locally controlled by a novel genus of specialized pro-resolving mediators (SPM) that orchestrate key…”
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Recent advances in the chemistry and biology of anti-inflammatory and specialized pro-resolving mediators biosynthesized from n-3 docosapentaenoic acid by Vik, Anders, Dalli, Jesmond, Hansen, Trond Vidar

“…[Display omitted] Several novel oxygenated polyunsaturated lipid mediators biosynthesized from n-3 docosapentaenoic acid were recently isolated from murine…”
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Macrophage Proresolving Mediators-the When and Where by Dalli, Jesmond, Serhan, Charles

“…Macrophages and neutrophils orchestrate acute inflammation and host defense as well as the resolution phase and return to homeostasis. In this article, we…”
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Identification of 14-series sulfido-conjugated mediators that promote resolution of infection and organ protection by Dalli, Jesmond, Chiang, Nan, Serhan, Charles N

“…Upon infection and inflammation, tissue repair and regeneration are essential in reestablishing function. Here we identified potent molecules present in…”
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Resolvin D1 and resolvin D2 govern local inflammatory tone in obese fat by Clària, Joan, Dalli, Jesmond, Yacoubian, Stephanie, Gao, Fei, Serhan, Charles N

“…The unprecedented increase in the prevalence of obesity and obesity-related disorders is causally linked to a chronic state of low-grade inflammation in…”
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Vagus nerve controls resolution and pro-resolving mediators of inflammation by Mirakaj, Valbona, Dalli, Jesmond, Granja, Tiago, Rosenberger, Peter, Serhan, Charles N

“…Resolution of inflammation is now recognized as a biosynthetically active process involving pro-resolving mediators. Here, we show in zymosan-initiated…”
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Requirement for the histone deacetylase Hdac3 for the inflammatory gene expression program in macrophages by Chen, Xuefen, Barozzi, Iros, Termanini, Alberto, Prosperini, Elena, Recchiuti, Antonio, Dalli, Jesmond, Mietton, Flore, Matteoli, Gianluca, Hiebert, Scott, Natoli, Gioacchino

“…Histone deacetylases (HDACs) regulate inflammatory gene expression, as indicated by the potent antiinflammatory activity of pan-HDAC inhibitors. However, the…”
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Neutrophil Resolvin E1 Receptor Expression and Function in Type 2 Diabetes by Freire, Marcelo O, Dalli, Jesmond, Serhan, Charles N, Van Dyke, Thomas E

“…Unresolved inflammation is key in linking metabolic dysregulation and the immune system in type 2 diabetes. Successful regulation of acute inflammation…”
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Resolvin T4 enhances macrophage cholesterol efflux to reduce vascular disease by Walker, Mary E., De Matteis, Roberta, Perretti, Mauro, Dalli, Jesmond

“…While cardiovascular disease (CVD) is one of the major co-morbidities in patients with rheumatoid arthritis (RA), the mechanism(s) that contribute to CVD in…”
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Blood pro-resolving mediators are linked with synovial pathology and are predictive of DMARD responsiveness in rheumatoid arthritis by Gomez, Esteban A., Colas, Romain A., Souza, Patricia R., Hands, Rebecca, Lewis, Myles J., Bessant, Conrad, Pitzalis, Costantino, Dalli, Jesmond

“…Biomarkers are needed for predicting the effectiveness of disease modifying antirheumatic drugs (DMARDs). Here, using functional lipid mediator profiling and…”
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