Hypolipidemic effect and modulation of hepatic enzymes by different edible oils in obese Wistar rats

The current study assessed the hypolipidemic effect and modulation of hepatic enzymes by different edible oils in obese Wistar rats. In order to conduct this study, 36 Wistar rats that were collected at 5 weeks of age and weighed an average of 70 g were split into two groups: 28 of them were fed a h...

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Bibliographic Details
Published in:	Heliyon Vol. 10; no. 4; p. e25880
Main Authors:	Alim, Md Abdul, Mumu, Tarana Jannat, Tamanna, Ummay Salma, Khan, Md Moin, Miah, Md Imran, Islam, Md Shahikul, Jesmin, Zannat Ara, Khan, Tayeba, Hasan, Md Rakibul, Alam, Md Jahangir, Murtaja Reza Linkon, Khan Md, Rahman, Md Nannur, Begum, Rokeya, Prodhan, Utpal Kumar
Format:	Journal Article
Language:	English
Published:	England Elsevier Ltd 29-02-2024 Elsevier
Subjects:	Edible oils Hepatic enzymes Hypolipidemic effect Obesity Obesity Edible oils Hepatic enzymes Hypolipidemic effect
Online Access:	Get full text
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Summary:	The current study assessed the hypolipidemic effect and modulation of hepatic enzymes by different edible oils in obese Wistar rats. In order to conduct this study, 36 Wistar rats that were collected at 5 weeks of age and weighed an average of 70 g were split into two groups: 28 of them were fed a high-fat diet (HFD) and 8 of them were fed a control diet. After 5 weeks of feeding, rats from the HFD (obese, n = 4) and the control diet group (n = 4) were sacrificed. Subsequently, the rest of obese rats (n = 24) were separated into six groups, including the continuing high-fat (CHF) diet group, rice bran oil (RBO) diet group, olive oil (OO) diet group, soybean oil (SO) diet group, cod liver oil (CLO) diet group, and sunflower oil (SFO) diet group, and the continuing control diet group (n = 4). Rats from each group were sacrificed following an additional 5 weeks, and all analytical tests were carried out. The results found that the interventions of RBO, CLO, and SFO in obese rats reduced their body weight non-significantly when compared with CHF. It was also observed that a non-significant reduction in weight of the heart, AAT, and EAT occurred by RBO, OO, SO, and CLO, while SFO reduced the AAT level significantly (p < 0.05). Besides, RBO, OO, SO, CLO, and SFO decreased IBAT and liver fat significantly compared to CHF. Similarly, the administration of RBO, OO, SO, and CLO reduced ALT significantly. RBO reduced GGT (p < 0.05) significantly, but other oils did not. The given oil has the efficiency to reduce TC, TAG, and LDL-C but increase HDL-C significantly. These findings suggest that different edible oils can ameliorate obesity, regulate lipid profiles, and modulate hepatic enzymes. [Display omitted] •Administration of edible oil-enriched diets to obese rats significantly reduced obesity.•Different edible oils encourage lowering fat storage in major fat depots.•Intervention oils have an effect on regulating the lipid profile in hyperlipidemic rats.•Rice bran oil (RBO) has a remarkable impact on restoring healthy liver functions.
Bibliography:	ObjectType-Article-1 SourceType-Scholarly Journals-1 ObjectType-Feature-2 content type line 23 These authors contributed equally to this work.
ISSN:	2405-8440 2405-8440
DOI:	10.1016/j.heliyon.2024.e25880