Search Results - "Jeschke, M G"

Animal models in burn research by Abdullahi, A, Amini-Nik, S, Jeschke, M. G

“…Burn injury is a severe form of trauma affecting more than 2 million people in North America each year. Burn trauma is not a single pathophysiological event…”
Get full text

Gene therapy in wound healing: present status and future directions by BRANSKI, L. K, PEREIRA, C. T, HERNDON, D. N, JESCHKE, M. G

“…Gene therapy was traditionally considered a treatment modality for patients with congenital defects of key metabolic functions or late-stage malignancies. The…”
Get full text

The effect of obesity on adverse outcomes and metabolism in pediatric burn patients by Kraft, R, Herndon, D N, Williams, F N, Al-Mousawi, A M, Finnerty, C C, Jeschke, M G

“…HYPOTHESIS: Obesity influences metabolism and increases the incidence of clinical complications and worsens outcomes in pediatric burn patients. DESIGN:…”
Get full text

Liposomal gene transfer of multiple genes is more effective than gene transfer of a single gene by JESCHKE, M. G, KLEIN, D

“…Liposomal gene transfer is an effective therapeutic approach for the treatment of several pathophysiologic states. The purpose of the present study was to…”
Get full text

Pre-clinical evaluation of liposomal gene transfer to improve dermal and epidermal regeneration by Branski, L K, Masters, O E, Herndon, D N, Mittermayr, R, Redl, H, Traber, D L, Cox, R A, Kita, K, Jeschke, M G

“…Liposomal gene transfer effectively enhances dermal and epidermal regeneration in burned rodents. To advance this treatment to clinical studies, we…”
Get full text

The combination of IGF-I and KGF cDNA improves dermal and epidermal regeneration by increased VEGF expression and neovascularization by JESCHKE, M. G, HERNDON, D. N

“…Insulin-like growth factor-I (IGF-I) and keratinocyte growth factor (KGF) cDNA gene transfer individually improves dermal and epidermal regeneration. The aim…”
Get full text

Non-viral liposomal keratinocyte growth factor (KGF) cDNA gene transfer improves dermal and epidermal regeneration through stimulation of epithelial and mesenchymal factors by JESCHKE, M. G, RICHTER, G, HÖFSTÖDTER, F, HERNDON, D. N, PEREZ-POLO, J-R, JAUCH, K-W

“…Keratinocyte growth factor (KGF) stimulates epithelial cell differentiation and proliferation, which are of major importance for wound healing. Local protein…”
Get full text

Early fluid resuscitation improves outcomes in severely burned children by Barrow, Robert E., Jeschke, Marc G., Herndon, David N.

“…Background: Recent evidence suggests that timely fluid resuscitation can significantly reduce multiorgan failure and mortality in thermally injured children…”
Get full text

The impact of operative time and hypothermia in acute burn surgery by Ziolkowski, N., Rogers, A.D., Xiong, W., Hong, B., Patel, S., Trull, B., Jeschke, M.G.

“…•Millions of burn injuries undergo operative treatment per year.•Limited evidence is available to guide perioperative practice.•Patients who undergo prolonged…”
Get full text

IGF-I gene transfer in thermally injured rats by JESCHKE, M. G, BARROW, R. E, HAWKINS, H. K, YANG, K, HAYES, R. L, LICHTENBELT, B. J, PEREZ-POLO, J. R, HERNDON, D. N

“…Exogenous insulin-like growth factor-I (IGF-I) is known to improve the pathophysiology of a thermal injury, however, deleterious side-effects have limited its…”
Get full text

The structure and composition of liposomes can affect skin regeneration, morphology and growth factor expression in acute wounds by JESCHKE, M. G, SANDMANN, G, FINNERTY, C. C, HERNDON, D. N, PEREIRA, C. T, SCHUBERT, T, KLEIN, D

“…Liposomal gene transfer is an effective therapeutic approach to improve dermal and epidermal regeneration. The purpose of the present study was to define…”
Get full text

Insulinlike growth factor I plus insulinlike growth factor binding protein 3 attenuates the proinflammatory acute phase response in severely burned children by JESCHKE, M. G, BARROW, R. E, HERNDON, D. N

“…To determine the effect of insulinlike growth factor I (IGF-I) in combination with its principal binding protein (IGFBP-3) on the hepatic acute phase response…”
Get full text

Polyurethane vascular prostheses decreases neointimal formation compared with expanded polytetrafluoroethylene by Jeschke, Marc G., Hermanutz, Valentin, Wolf, Steven E., Köveker, Gerhard B.

“…Purpose: Synthetic grafts have been increasingly used for complex vascular reconstructions in patients with limited autologous vein availability. Materials…”
Get full text

Composition and characteristics of an autologous thrombocyte gel by Altmeppen, J, Hansen, E, Bonnländer, G.L, Horch, R.E, Jeschke, M.G

“…The purpose of the current study was to characterize and compare an autologous thrombocyte gel containing several blood components with a commercially…”
Get full text

Therapeutic success and efficacy of nonviral liposomal cDNA gene transfer to the skin in vivo is dose dependent by JESCHKE, M. G, RICHTER, G, HERNDON, D. N, GEISSLER, E. K, HARTL, M, HOFSTÄTTER, F, JAUCH, K.-W, PEREZ-POLO, J. R

“…It is well documented that responses to growth factor treatment typically display bell-shaped dose responses that can significantly affect efficacy. Here we…”
Get full text

Use of oxandrolone in ventilator dependent surgical patients by Pereira, C T, Jeschke, M G, Herndon, D N

Get full text

Nutritional hepatic steatosis and mortality after burn injury in rats by Mittendorfer, B., Jeschke, M.G., Wolf, S.E., Sidossis, L.S.

“…Abstract To investigate the effects of diet composition and starvation on hepatic steatosis and mortality after severe burn injury in rats. Experiment 1: rats…”
Get full text

Biodistribution and Feasibility of Non-Viral IGF-I Gene Transfers in Thermally Injured Skin by Jeschke, Marc G, Barrow, Robert E, Hawkins, Hal K, Tao, Ziming, Perez-Polo, J Regino, Herndon, David N

“…Gene therapy using cationic liposomes containing cDNA is a relatively new approach with great potential; however, little is known about the mechanisms of…”
Get full text

Early release of third-degree eyelid burns prevents eye injury by BARROW, R. E, JESCHKE, M. G, HERNDON, D. N

“…Burns to the eyelids occur in more than 20 percent of flame injuries and can lead to ocular damage and even blindness. Burn wound contracture can cause…”
Get full text

Recombinant Human Growth Hormone Alters Acute Phase Reactant Proteins, Cytokine Expression, and Liver Morphology in Burned Rats by Jeschke, Marc G., Herndon, David N., Wolf, Steven E., DebRoy, Meelie A., Rai, Jyoti, Lichtenbelt, Bart J., Barrow, Robert E.

“…Background.The effects of exogenous recombinant human growth hormone (rhGH) on hepatic acute phase reactant proteins, cytokine expression, and liver morphology…”
Get full text