Search Results - "Jeroen, Dekervel"

Encorafenib, Binimetinib, and Cetuximab in BRAF V600E–Mutated Colorectal Cancer by Kopetz, Scott, Grothey, Axel, Yaeger, Rona, Van Cutsem, Eric, Desai, Jayesh, Yoshino, Takayuki, Wasan, Harpreet, Ciardiello, Fortunato, Loupakis, Fotios, Hong, Yong Sang, Steeghs, Neeltje, Guren, Tormod K, Arkenau, Hendrik-Tobias, Garcia-Alfonso, Pilar, Pfeiffer, Per, Orlov, Sergey, Lonardi, Sara, Elez, Elena, Kim, Tae-Won, Schellens, Jan H.M, Guo, Christina, Krishnan, Asha, Dekervel, Jeroen, Morris, Van, Calvo Ferrandiz, Aitana, Tarpgaard, L.S, Braun, Michael, Gollerkeri, Ashwin, Keir, Christopher, Maharry, Kati, Pickard, Michael, Christy-Bittel, Janna, Anderson, Lisa, Sandor, Victor, Tabernero, Josep

“…Colorectal cancers with BRAF mutations have an aggressive natural history and are often resistant to therapy. A treatment regimen that combined BRAF…”
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[18F]AlF-NOTA-octreotide PET imaging: biodistribution, dosimetry and first comparison with [68Ga]Ga-DOTATATE in neuroendocrine tumour patients by Pauwels, Elin, Cleeren, Frederik, Tshibangu, Térence, Koole, Michel, Serdons, Kim, Dekervel, Jeroen, Van Cutsem, Eric, Verslype, Chris, Van Laere, Koen, Bormans, Guy, Deroose, Christophe M.

“…Purpose The widespread use of gallium-68-labelled somatostatin analogue (SSA) PET, the current standard for somatostatin receptor (SSTR) imaging, is limited by…”
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Expression profiling of budding cells in colorectal cancer reveals an EMT-like phenotype and molecular subtype switching by De Smedt, Linde, Palmans, Sofie, Andel, Daan, Govaere, Olivier, Boeckx, Bram, Smeets, Dominiek, Galle, Eva, Wouters, Jasper, Barras, David, Suffiotti, Madeleine, Dekervel, Jeroen, Tousseyn, Thomas, De Hertogh, Gert, Prenen, Hans, Tejpar, Sabine, Lambrechts, Diether, Sagaert, Xavier

“…Background: Tumour budding, described as the presence of single cells or small clusters of up to five tumour cells at the invasive margin, is established as a…”
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PD-1- CD45RA+ effector-memory CD8 T cells and CXCL10+ macrophages are associated with response to atezolizumab plus bevacizumab in advanced hepatocellular carcinoma by Cappuyns, Sarah, Philips, Gino, Vandecaveye, Vincent, Boeckx, Bram, Schepers, Rogier, Van Brussel, Thomas, Arijs, Ingrid, Mechels, Aurelie, Bassez, Ayse, Lodi, Francesca, Jaekers, Joris, Topal, Halit, Topal, Baki, Bricard, Orian, Qian, Junbin, Van Cutsem, Eric, Verslype, Chris, Lambrechts, Diether, Dekervel, Jeroen

“…The combination of atezolizumab plus bevacizumab (atezo/bev) has dramatically changed the treatment landscape of advanced HCC (aHCC), achieving durable…”
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Anti-Cancer Activity of Acriflavine as Metabolic Inhibitor of OXPHOS in Pancreas Cancer Xenografts by Bulle, Ashenafi, Dekervel, Jeroen, Deschuttere, Lise, Nittner, David, Van Cutsem, Eric, Verslype, Chris, van Pelt, Jos

“…All currently available therapies for the treatment of pancreatic ductal adenocarcinoma (PDAC) show limited success. PDACs fast progression depends on the…”
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Gemcitabine Recruits M2-Type Tumor-Associated Macrophages into the Stroma of Pancreatic Cancer by Bulle, Ashenafi, Dekervel, Jeroen, Deschuttere, Lise, Nittner, David, Libbrecht, Louis, Janky, Rekin's, Plaisance, Stéphane, Topal, Baki, Coosemans, An, Lambrechts, Diether, Van Cutsem, Eric, Verslype, Chris, van Pelt, Jos

“…BACKGROUND: Pancreatic ductal adenocarcinoma (PDAC) is a very lethal disease that can develop therapy resistance over time. The dense stroma in PDAC plays a…”
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A phase 1b study of the MET inhibitor capmatinib combined with cetuximab in patients with MET-positive colorectal cancer who had progressed following anti-EGFR monoclonal antibody treatment by Delord, Jean-Pierre, Argilés, Guillem, Fayette, Jerôme, Wirth, Lori, Kasper, Stefan, Siena, Salvatore, Mesia, Ricard, Berardi, Rossana, Cervantes, Andrés, Dekervel, Jeroen, Zhao, Sylvia, Sun, Yongjian, Hao, Huai-Xiang, Tiedt, Ralph, Vicente, Sergio, Myers, Andrea, Siu, Lillian L.

“…Summary Background Overcoming resistance to anti-epidermal growth factor receptor (EGFR) monoclonal antibodies (mAbs) in patients with KRAS wildtype (WT)…”
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Pleural decortication and hyperthermic intrathoracic chemotherapy for pseudomyxoma by Proesmans, Viktor, Vandaele, Tom, Van Slambrouck, Jan, Wolthuis, Albert, D´Hoore, André, Dekervel, Jeroen, Van Cutsem, Eric, Dresen, Raphaëla, De Hertogh, Gert, Degezelle, Karlien, Van Raemdonck, Dirk, Nafteux, Philippe, Ceulemans, Laurens J.

“…Aim: Pleural dissemination of pseudomyxoma peritonei (PMP) is an extremely rare diagnosis, for which no standard therapy is available. Methods: We describe the…”
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Intra-individual qualitative and quantitative comparison of [68Ga]Ga-DOTATATE PET/CT and PET/MRI by Lens, Géraldine, Ahmadi Bidakhvidi, Niloefar, Vandecaveye, Vincent, Grauwels, Steven, Laenen, Annouschka, Deckers, Wies, Peeters, Ronald, Dresen, Raphaëla C., Dekervel, Jeroen, Verslype, Chris, Nackaerts, Kristiaan, Clement, Paul M., Van Cutsem, Eric, Koole, Michel, Goffin, Karolien, Van Laere, Koen, Deroose, Christophe M.

“…Background: Somatostatin receptor (SSTR) positron emission tomography (PET) is a cornerstone of neuroendocrine tumor (NET) management. Hybrid PET/magnetic…”
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Acriflavine Inhibits Acquired Drug Resistance by Blocking the Epithelial-to-Mesenchymal Transition and the Unfolded Protein Response by Dekervel, Jeroen, Bulle, Ashenafi, Windmolders, Petra, Lambrechts, Diether, Van Cutsem, Eric, Verslype, Chris, van Pelt, Jos

“…Abstract Epithelial-to-mesenchymal transition (EMT) is linked to tumor invasion, drug resistance and aggressive disease and this is largely dependent on the…”
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Extended criteria for liver transplantation in hepatocellular carcinoma. A retrospective, multicentric validation study in Belgium by Degroote, Helena, Callebout, Eduard, Iesari, Samuele, Dekervel, Jeroen, Schreiber, Jonas, Pirenne, Jacques, Verslype, Chris, Ysebaert, Dirk, Michielsen, Peter, Lucidi, Valerio, Moreno, Christophe, Detry, Olivier, Delwaide, Jean, Troisi, Roberto Ivan, Lerut, Jan Paul, Van Vlierberghe, Hans

“…Recent studies indicate that a group of patients with cirrhosis receiving a liver transplantation for hepatocellular cancer (HCC) beyond the Milan Criteria…”
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Quantitative comparison of pre-treatment predictive and post-treatment measured dosimetry for selective internal radiation therapy using cone-beam CT for tumor and liver perfusion territory definition by Jafargholi Rangraz, Esmaeel, Tang, Xikai, Van Laeken, Charlotte, Maleux, Geert, Dekervel, Jeroen, Van Cutsem, Eric, Verslype, Chris, Baete, Kristof, Nuyts, Johan, Deroose, Christophe M.

“…Background Selective internal radiation therapy (SIRT) is a promising treatment for unresectable hepatic malignancies. Predictive dose calculation based on a…”
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Hypoxia-Driven Gene Expression Is an Independent Prognostic Factor in Stage II and III Colon Cancer Patients by DEKERVEL, Jeroen, HOMPES, Daphne, VAN MALENSTEIN, Hannah, POPOVIC, Dusan, SAGAERT, Xavier, DE MOOR, Bart, VAN CUTSEM, Eric, D'HOORE, André, VERSLYPE, Chris, VAN PELT, Jos

“…Hypoxia is considered a major microenvironmental factor influencing cancer behavior. Our aim was to develop a hypoxia-based gene score that could identify high…”
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Cancer Surveillance in Healthy Carriers of Germline Pathogenic Variants in BRCA1/2: A Review of Secondary Prevention Guidelines by Dullens, Boudewijn, de Putter, Robin, Lambertini, Matteo, Toss, Angela, Han, Sileny, Van Nieuwenhuysen, Els, Van Gorp, Toon, Vanderstichele, Adriaan, Van Ongeval, Chantal, Keupers, Machteld, Prevos, Renate, Celis, Valerie, Dekervel, Jeroen, Everaerts, Wouter, Wildiers, Hans, Nevelsteen, Ines, Neven, Patrick, Timmerman, Dirk, Smeets, Ann, Denayer, Ellen, Van Buggenhout, Griet, Legius, Eric, Punie, Kevin

“…Germline pathogenic alterations in the breast cancer susceptibility genes 1 (BRCA1) and 2 (BRCA2) are the most prevalent causes of hereditary breast and…”
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Prospective comparison of [18F]AlF-NOTA-octreotide PET/MRI to [68Ga]Ga-DOTATATE PET/CT in neuroendocrine tumor patients by Boeckxstaens, Lennert, Pauwels, Elin, Vandecaveye, Vincent, Deckers, Wies, Cleeren, Frederik, Dekervel, Jeroen, Vandamme, Timon, Serdons, Kim, Koole, Michel, Bormans, Guy, Laenen, Annouschka, Clement, Paul M., Geboes, Karen, Van Cutsem, Eric, Nackaerts, Kristiaan, Stroobants, Sigrid, Verslype, Chris, Van Laere, Koen, Deroose, Christophe M.

“…Background Fluorine-18-labeled SSAs have the potential to become the next-generation tracer in SSTR-imaging in neuroendocrine tumor (NET) patients given their…”
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Constitutional mismatch repair deficiency mimicking Lynch syndrome is associated with hypomorphic mismatch repair gene variants by Gallon, Richard, Brekelmans, Carlijn, Martin, Marie, Bours, Vincent, Schamschula, Esther, Amberger, Albert, Muleris, Martine, Colas, Chrystelle, Dekervel, Jeroen, De Hertogh, Gert, Coupier, Jérôme, Colleye, Orphal, Sepulchre, Edith, Burn, John, Brems, Hilde, Legius, Eric, Wimmer, Katharina

“…Lynch syndrome (LS) and constitutional mismatch repair deficiency (CMMRD) are distinct cancer syndromes caused, respectively, by mono- and bi-allelic germline…”
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Nonoperative versus operative approach according to the response to neoadjuvant chemoradiotherapy for rectal cancer: A prospective cohort study by Bulens, Philippe P., Smets, Lien, Debucquoy, Annelies, Joye, Ines, D'Hoore, André, Wolthuis, Albert, Debrun, Lynn, Dekervel, Jeroen, Van Cutsem, Eric, Dresen, Raphaëla, Vandecaveye, Vincent, Deroose, Christophe M., Sagaert, Xavier, Haustermans, Karin

“…•Watch-and-wait patients after chemoradiotherapy for rectal cancer have good functional outcome.•No survival differences were seen between patients undergoing…”
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Oncogenic role of PMEPA1 and its association with immune exhaustion and TGF-β activation in HCC by Piqué-Gili, Marta, Andreu-Oller, Carmen, Mesropian, Agavni, Esteban-Fabró, Roger, Bárcena-Varela, Marina, Ruiz de Galarreta, Marina, Montironi, Carla, Martinez-Quetglas, Iris, Cappuyns, Sarah, Peix, Judit, Keraite, Ieva, Gris-Oliver, Albert, Fernández-Martínez, Elisa, Mauro, Ezequiel, Torres-Martin, Miguel, Abril-Fornaguera, Jordi, Lindblad, Katherine E., Lambrechts, Diether, Dekervel, Jeroen, Thung, Swan N., Sia, Daniela, Lujambio, Amaia, Pinyol, Roser, Llovet, Josep M.

“…Transforming growth factor β (TGF-β) plays an oncogenic role in advanced cancer by promoting cell proliferation, metastasis and immunosuppression. PMEPA1…”
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A fatal wound complication following sequential anti-angiogenesis, immune checkpoint inhibition and ultra-hypofractionated radiotherapy by Orazem, Miha, Draulans, Cédric, Spaas, Mathieu, Van Cutsem, Eric, Debecker, Marina, De Meerleer, Gert, Tejpar, Sabine, Dekervel, Jeroen, Haustermans, Karin

“…Purpose Multimodality treatments combining radiotherapy, immune therapy and/or targeted therapy are under heavy investigation. Promising data from clinical…”
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Transcatheter Arterial Chemoembolization with Doxorubicin-Eluting Superabsorbent Polymer Microspheres in the Treatment of Hepatocellular Carcinoma: Midterm Follow-up by Dekervel, Jeroen, MD, van Malenstein, Hannah, MD, PhD, Vandecaveye, Vincent, MD, PhD, Nevens, Frederik, MD, PhD, van Pelt, Jos, Dr, Ing, Heye, Sam, MD, PhD, Laleman, Wim, MD, PhD, Van Steenbergen, Werner, MD, PhD, Vaninbroukx, Johan, MD, Verslype, Chris, MD, PhD, Maleux, Geert, MD, PhD

“…Abstract Purpose To investigate prospectively the safety, tolerability, and efficacy of transarterial chemoembolization using superabsorbent polymer (SAP)…”
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