Search Results - "Jeremy Thorner"

Function and regulation in MAPK signaling pathways: Lessons learned from the yeast Saccharomyces cerevisiae by Chen, Raymond E., Thorner, Jeremy

“…Signaling pathways that activate different mitogen-activated protein kinases (MAPKs) elicit many of the responses that are evoked in cells by changes in…”
Get full text

Synthesis and function of membrane phosphoinositides in budding yeast, Saccharomyces cerevisiae by Strahl, Thomas, Thorner, Jeremy

“…It is now well appreciated that derivatives of phosphatidylinositol (PtdIns) are key regulators of many cellular processes in eukaryotes. Of particular…”
Get full text

Rab5 GTPases are required for optimal TORC2 function by Locke, Melissa N, Thorner, Jeremy

“…Target of rapamycin complex-2 (TORC2), a conserved protein kinase complex, is an indispensable regulator of plasma membrane homeostasis. In budding yeast ( ),…”
Get full text

Protein kinase Ypk1 phosphorylates regulatory proteins Orm1 and Orm2 to control sphingolipid homeostasis in Saccharomyces cerevisiae by Roelants, Françoise M, Breslow, David K, Muir, Alexander, Weissman, Jonathan S, Thorner, Jeremy

“…The Orm family proteins are conserved integral membrane proteins of the endoplasmic reticulum that are key homeostatic regulators of sphingolipid biosynthesis…”
Get full text

TORC2-dependent protein kinase Ypk1 phosphorylates ceramide synthase to stimulate synthesis of complex sphingolipids by Muir, Alexander, Ramachandran, Subramaniam, Roelants, Françoise M, Timmons, Garrett, Thorner, Jeremy

“…Plasma membrane lipid composition must be maintained during growth and under environmental insult. In yeast, signaling mediated by TOR Complex 2…”
Get full text

Subunit-dependent modulation of septin assembly: budding yeast septin Shs1 promotes ring and gauze formation by Garcia, 3rd, Galo, Bertin, Aurelie, Li, Zhu, Song, Yi, McMurray, Michael A, Thorner, Jeremy, Nogales, Eva

“…Septins are conserved guanosine triphosphate-binding cytoskeletal proteins involved in membrane remodeling. In budding yeast, five mitotic septins (Cdc3,…”
Get full text

Sphingolipid biosynthesis upregulation by TOR complex 2-Ypk1 signaling during yeast adaptive response to acetic acid stress by Guerreiro, Joana F, Muir, Alexander, Ramachandran, Subramaniam, Thorner, Jeremy, Sá-Correia, Isabel

“…Acetic acid-induced inhibition of yeast growth and metabolism limits the productivity of industrial fermentation processes, especially when lignocellulosic…”
Get more information

Phosphatidylinositol -4,5- bisphosphate Promotes Budding Yeast Septin Filament Assembly and Organization by Bertin, Aurélie, McMurray, Michael A., Thai, Luong, Garcia, Galo, Votin, Violet, Grob, Patricia, Allyn, Theresa, Thorner, Jeremy, Nogales, Eva

“…Septins are a conserved family of GTP-binding proteins that assemble into symmetric linear heterooligomeric complexes, which in turn are able to polymerize…”
Get full text

Reciprocal Phosphorylation of Yeast Glycerol-3-Phosphate Dehydrogenases in Adaptation to Distinct Types of Stress by Lee, Yong Jae, Jeschke, Grace R., Roelants, Françoise M., Thorner, Jeremy, Turk, Benjamin E.

“…Article Usage Stats Services MCB Citing Articles Google Scholar PubMed Related Content Social Bookmarking CiteULike Delicious Digg Facebook Google+ Mendeley…”
Get full text

Septin Filament Formation Is Essential in Budding Yeast by McMurray, Michael A., Bertin, Aurelie, Garcia, Galo, Lam, Lisa, Nogales, Eva, Thorner, Jeremy

“…Septins are GTP-binding proteins that form ordered, rod-like multimeric complexes and polymerize into filaments, but how such supramolecular structure…”
Get full text

Septins: molecular partitioning and the generation of cellular asymmetry by McMurray, Michael A, Thorner, Jeremy

“…During division, certain cellular contents can be distributed unequally; daughter cells with different fates have different needs. Septins are proteins that…”
Get full text

Septin Collar Formation in Budding Yeast Requires GTP Binding and Direct Phosphorylation by the PAK, Cla4 by Versele, Matthias, Thorner, Jeremy

“…Assembly at the mother-bud neck of a filamentous collar containing five septins (Cdc3, Cdc10, Cdc11, Cdc12, and Shs1) is necessary for proper morphogenesis and…”
Get full text

protein kinase network regulates the function of aminophospholipid flippases by Roelants, Françoise M, Baltz, Alexander G, Trott, Amy E, Fereres, Sol, Thorner, Jeremy

“…Limited exposure of aminophospholipids on the outer leaflet of the plasma membrane is a fundamental feature of eukaryotic cells and is maintained by the action…”
Get full text

Phosphorylation by the stress-activated MAPK Slt2 down-regulates the yeast TOR complex 2 by Leskoske, Kristin L, Roelants, Françoise M, Emmerstorfer-Augustin, Anita, Augustin, Christoph M, Si, Edward P, Hill, Jennifer M, Thorner, Jeremy

“…target of rapamycin (TOR) complex 2 (TORC2) is an essential regulator of plasma membrane lipid and protein homeostasis. How TORC2 activity is modulated in…”
Get full text

Saccharomyces cerevisiae septins: Supramolecular organization of heterooligomers and the mechanism of filament assembly by Bertin, Aurelie, McMurray, Michael A, Grob, Patricia, Park, Sang-Shin, Garcia, Galo III, Patanwala, Insiyyah, Ng, Ho-leung, Alber, Tom, Thorner, Jeremy, Nogales, Eva

“…Mitotic yeast cells express five septins (Cdc3, Cdc10, Cdc11, Cdc12, and Shs1/Sep7). Only Shs1 is nonessential. The four essential septins form a complex…”
Get full text

The Carboxy-Terminal Tails of Septins Cdc11 and Shs1 Recruit Myosin-II Binding Factor Bni5 to the Bud Neck in Saccharomyces cerevisiae by Finnigan, Gregory C, Booth, Elizabeth A, Duvalyan, Angela, Liao, Elizabeth N, Thorner, Jeremy

“…Septins are a conserved family of GTP-binding proteins that form heterooctameric complexes that assemble into higher-order structures. In yeast, septin…”
Get full text

The Stress-Sensing TORC2 Complex Activates Yeast AGC-Family Protein Kinase Ypk1 at Multiple Novel Sites by Leskoske, Kristin L, Roelants, Françoise M, Martinez Marshall, Maria Nieves, Hill, Jennifer M, Thorner, Jeremy

“…Yeast ( ) target of rapamycin (TOR) complex 2 (TORC2) is a multi-subunit plasma membrane-associated protein kinase and vital growth regulator. Its essential…”
Get full text

Stress resistance and signal fidelity independent of nuclear MAPK function by Westfall, Patrick J, Patterson, Jesse C, Chen, Raymond E, Thorner, Jeremy

“…Elevated external solute stimulates a conserved MAPK cascade that elicits responses that maintain osmotic balance. The yeast high-osmolarity glycerol (HOG)…”
Get full text

mCAL: A New Approach for Versatile Multiplex Action of Cas9 Using One sgRNA and Loci Flanked by a Programmed Target Sequence by Finnigan, Gregory C, Thorner, Jeremy

“…Genome editing exploiting CRISPR/Cas9 has been adopted widely in academia and in the biotechnology industry to manipulate DNA sequences in diverse organisms…”
Get full text

Down-regulation of TORC2-Ypk1 signaling promotes MAPK-independent survival under hyperosmotic stress by Muir, Alexander, Roelants, Françoise M, Timmons, Garrett, Leskoske, Kristin L, Thorner, Jeremy

“…In eukaryotes, exposure to hypertonic conditions activates a MAPK (Hog1 in Saccharomyces cerevisiae and ortholog p38 in human cells). In yeast, intracellular…”
Get full text