Search Results - "Jeremy, Nigri"

Cholesterol uptake disruption, in association with chemotherapy, is a promising combined metabolic therapy for pancreatic adenocarcinoma by Guillaumond, Fabienne, Bidaut, Ghislain, Ouaissi, Mehdi, Servais, Stéphane, Gouirand, Victoire, Olivares, Orianne, Lac, Sophie, Borge, Laurence, Roques, Julie, Gayet, Odile, Pinault, Michelle, Guimaraes, Cyrille, Nigri, Jérémy, Loncle, Céline, Lavaut, Marie-Noëlle, Garcia, Stéphane, Tailleux, Anne, Staels, Bart, Calvo, Ezequiel, Tomasini, Richard, Iovanna, Juan Lucio, Vasseur, Sophie

“…The malignant progression of pancreatic ductal adenocarcinoma (PDAC) is accompanied by a profound desmoplasia, which forces proliferating tumor cells to…”
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Cancer-associated fibroblast-derived annexin A6+ extracellular vesicles support pancreatic cancer aggressiveness by Leca, Julie, Martinez, Sébastien, Lac, Sophie, Nigri, Jérémy, Secq, Véronique, Rubis, Marion, Bressy, Christian, Sergé, Arnauld, Lavaut, Marie-Noelle, Dusetti, Nelson, Loncle, Céline, Roques, Julie, Pietrasz, Daniel, Bousquet, Corinne, Garcia, Stéphane, Granjeaud, Samuel, Ouaissi, Mehdi, Bachet, Jean Baptiste, Brun, Christine, Iovanna, Juan L, Zimmermann, Pascale, Vasseur, Sophie, Tomasini, Richard

“…The intratumoral microenvironment, or stroma, is of major importance in the pathobiology of pancreatic ductal adenocarcinoma (PDA), and specific conditions in…”
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Sympathetic axonal sprouting induces changes in macrophage populations and protects against pancreatic cancer by Guillot, Jérémy, Dominici, Chloé, Lucchesi, Adrien, Nguyen, Huyen Thi Trang, Puget, Angélique, Hocine, Mélanie, Rangel-Sosa, Martha M., Simic, Milesa, Nigri, Jérémy, Guillaumond, Fabienne, Bigonnet, Martin, Dusetti, Nelson, Perrot, Jimmy, Lopez, Jonathan, Etzerodt, Anders, Lawrence, Toby, Pudlo, Pierre, Hubert, Florence, Scoazec, Jean-Yves, van de Pavert, Serge A., Tomasini, Richard, Chauvet, Sophie, Mann, Fanny

“…Neuronal nerve processes in the tumor microenvironment were highlighted recently. However, the origin of intra-tumoral nerves remains poorly known, in part…”
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Peritumoral adipose tissue lipolysis activates the lymphatic system to promote PDAC-associated cachexia by Fabienne, De Toni, Jeremy, Nigri, Richard, Tomasini, Jean, Galitzky, Anne, Bouloumié, Barbara, Garmy-Susini

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LIF Drives Neural Remodeling in Pancreatic Cancer and Offers a New Candidate Biomarker by Bressy, Christian, Lac, Sophie, Nigri, Jérémy, Leca, Julie, Roques, Julie, Lavaut, Marie-Nöelle, Secq, Véronique, Guillaumond, Fabienne, Bui, Thi-Thien, Pietrasz, Daniel, Granjeaud, Samuel, Bachet, Jean-Baptiste, Ouaissi, Mehdi, Iovanna, Juan, Vasseur, Sophie, Tomasini, Richard

“…Pancreatic ductal adenocarcinoma (PDAC) is characterized by extensive stroma and pathogenic modifications to the peripheral nervous system that elevate…”
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Stromal protein βig-h3 reprogrammes tumour microenvironment in pancreatic cancer by Goehrig, Delphine, Nigri, Jérémy, Samain, Rémi, Wu, Zhichong, Cappello, Paola, Gabiane, Gaëlle, Zhang, Xinyi, Zhao, Yajie, Kim, In-San, Chanal, Marie, Curto, Roberta, Hervieu, Valerie, de La Fouchardière, Christelle, Novelli, Francesco, Milani, Pascale, Tomasini, Richard, Bousquet, Corinne, Bertolino, Philippe, Hennino, Ana

“…Pancreatic cancer is associated with an abundant stromal reaction leading to immune escape and tumour growth. This massive stroma drives the immune escape in…”
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CD9 mediates the uptake of extracellular vesicles from cancer-associated fibroblasts that promote pancreatic cancer cell aggressiveness by Nigri, Jérémy, Leca, Julie, Tubiana, Sarah-Simha, Finetti, Pascal, Guillaumond, Fabienne, Martinez, Sébastien, Lac, Sophie, Iovanna, Juan L, Audebert, Stéphane, Camoin, Luc, Vasseur, Sophie, Bertucci, François, Tomasini, Richard

“…In pancreatic ductal adenocarcinoma (PDAC), signaling from stromal cells is implicated in metastatic progression. Tumor-stroma cross-talk is often mediated…”
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SK2 channels set a signalling hub bolstering CAF-triggered tumourigenic processes in pancreatic cancer by Rapetti-Mauss, Raphael, Nigri, Jérémy, Berenguier, Camille, Finetti, Pascal, Tubiana, Sarah Simha, Labrum, Bonnie, Allegrini, Benoit, Pellissier, Bernard, Efthymiou, Georgios, Hussain, Zainab, Bousquet, Corinne, Dusetti, Nelson, Bertucci, François, Guizouarn, Hélène, Melnyk, Patricia, Borgese, Franck, Tomasini, Richard, Soriani, Olivier

“…Intercellular communication within pancreatic ductal adenocarcinoma (PDAC) dramatically contributes to metastatic processes. The underlying mechanisms are…”
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PAP/REG3A favors perineural invasion in pancreatic adenocarcinoma and serves as a prognostic marker by Nigri, Jérémy, Gironella, Meritxell, Bressy, Christian, Vila-Navarro, Elena, Roques, Julie, Lac, Sophie, Bontemps, Caroline, Kozaczyk, Coraline, Cros, Jérôme, Pietrasz, Daniel, Maréchal, Raphaël, Van Laethem, Jean-Luc, Iovanna, Juan, Bachet, Jean-Baptiste, Folch-Puy, Emma, Tomasini, Richard

“…Pancreatic ductal adenocarcinoma (PDA) is a fatal and insidious malignant disease for which clinicians’ tools are restricted by the current limits in knowledge…”
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Pancreatic preneoplastic lesions plasma signatures and biomarkers based on proteome profiling of mouse models by Ligat, Laetitia, Saint-Laurent, Nathalie, El-Mrani, Aïcha, Gigoux, Véronique, Al Saati, Talal, Tomasini, Richard, Nigri, Jérémy, Dejean, Sébastien, Pont, Frédéric, Baer, Romain, Guillermet-Guibert, Julie, Cordelier, Pierre, Lopez, Frédéric, Dufresne, Marlène

“…Background: Pancreatic ductal adenocarcinoma (PDAC) is one of the most lethal malignancies with a mortality that is almost identical to incidence. Because…”
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The Cellular and Biological Impact of Extracellular Vesicles in Pancreatic Cancer by Hussain, Zainab, Nigri, Jeremy, Tomasini, Richard

“…Deciphering the interactions between tumor and stromal cells is a growing field of research to improve pancreatic cancer-associated therapies and patients’…”
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Dendritic cell-based vaccination: powerful resources of immature dendritic cells against pancreatic adenocarcinoma by Collignon, Aurélie, Silvy, Françoise, Robert, Stéphane, Trad, Malika, Germain, Sébastien, Nigri, Jérémy, André, Frédéric, Rigot, Véronique, Tomasini, Richard, Bonnotte, Bernard, Lombardo, Dominique, Mas, Eric, Beraud, Evelyne

“…Pancreatic adenocarcinoma (PAC) has a poor prognosis. One treatment approach, investigated here, is to reinforce antitumor immunity. Dendritic cells (DCs) are…”
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Pharmacologic Normalization of Pancreatic Cancer-Associated Fibroblast Secretome Impairs Prometastatic Cross-Talk With Macrophages by Samain, Rémi, Brunel, Alexia, Douché, Thibault, Fanjul, Marjorie, Cassant-Sourdy, Stéphanie, Rochotte, Julia, Cros, Jérôme, Neuzillet, Cindy, Raffenne, Jérôme, Duluc, Camille, Perraud, Aurélie, Nigri, Jérémy, Gigoux, Véronique, Bieche, Ivan, Ponzo, Matteo, Carpentier, Gilles, Cascone, Ilaria, Tomasini, Richard, Schmid, Herbert A., Mathonnet, Muriel, Nicolle, Rémy, Bousquet, Marie-Pierre, Martineau, Yvan, Pyronnet, Stéphane, Jean, Christine, Bousquet, Corinne

“…Cancer-associated fibroblasts (CAFs) from pancreatic adenocarcinoma (PDA) present high protein synthesis rates. CAFs express the G-protein–coupled somatostatin…”
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Ketogenic HMG‐CoA lyase and its product β‐hydroxybutyrate promote pancreatic cancer progression by Gouirand, Victoire, Gicquel, Tristan, Lien, Evan C, Jaune‐Pons, Emilie, Da Costa, Quentin, Finetti, Pascal, Metay, Elodie, Duluc, Camille, Mayers, Jared R, Audebert, Stephane, Camoin, Luc, Borge, Laurence, Rubis, Marion, Leca, Julie, Nigri, Jeremy, Bertucci, François, Dusetti, Nelson, Iovanna, Juan Lucio, Tomasini, Richard, Bidaut, Ghislain, Guillaumond, Fabienne, Vander Heiden, Matthew G, Vasseur, Sophie

“…Pancreatic ductal adenocarcinoma (PDA) tumor cells are deprived of oxygen and nutrients and therefore must adapt their metabolism to ensure proliferation. In…”
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Abstract C086: Investigating resistance to RAS therapies in PDAC models by Ting, Hsiu-Chi, Kim, Sun, Park, Youngkyu, Deschnes, Astrid, Kastan, Jonathan, Nigri, Jeremy, Tuveson, David

“…Pancreatic ductal adenocarcinoma (PDAC) carries a significantly unfavorable prognosis due to delayed detection and limited therapeutic options, resulting in…”
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Abstract B040: Neural control of cancer-associated fibroblasts in PDAC by Nigri, Jeremy, Lan, Wenjun, Chavan, Sangeeta S, Park, Youngkyu, Borniger, Jeremy, Tracey, Kevin J, Tuveson, David A

“…Pancreatic ductal adenocarcinoma (PDAC) poses a formidable challenge to public health, with a dismal 5-year survival rate and a projected rise as the second…”
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Abstract B081: SOAT1 as a targetable KRAS dependency in PDAC by Lan, Wenjun, Sun, Shoujun, Nigri, Jeremy, Homer, Josh, Park, Young, Deschenes, Astrid, Cifani, Paolo, Cross, Justin, Gaeth, Victoria, Kim, Sunny, Ting, Shawn, Rubino, Rachel, Moses, John, Tuveson, David

“…Metabolic rewiring is an emerging hallmark of neoplasia. In pancreatic ductal adenocarcinoma (PDAC), KRAS alters myriad metabolic programs to promote cellular…”
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Coordinating Effect of VEGFC and Oleic Acid Participates to Tumor Lymphangiogenesis by Morfoisse, Florent, De Toni, Fabienne, Nigri, Jeremy, Hosseini, Mohsen, Zamora, Audrey, Tatin, Florence, Pujol, Françoise, Sarry, Jean-Emmanuel, Langin, Dominique, Lacazette, Eric, Prats, Anne-Catherine, Tomasini, Richard, Galitzky, Jean, Bouloumié, Anne, Garmy-Susini, Barbara

“…In cancer, the lymphatic system is hijacked by tumor cells that escape from primary tumor and metastasize to the sentinel lymph nodes. Tumor lymphangiogenesis…”
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Abstract A61: CAF-derived ANXA6+-exosomes support pancreatic cancer aggressiveness and serve as a circulating biomarker by Leca, Julie, Martinez, Sebastien, Lac, Sophie, Nigri, Jeremy, Secq, Veronique, Rubis, Marion, Dusetti, Nelson, Loncle, Celine, Roques, Julie, Pietrasz, Daniel, Garcia, Stéphane, Granjeaud, Samuel, Ouaissi, Mehdi, Bachet, Jean-Baptiste, Brun, Christine, Iovanna, Juan L., Zimmermann, Pascale, Vasseur, Sophie, Tomasini, Richard

“…Pancreatic ductal adenocarcinoma (PDA) is one of deadliest human malignancies with a median survival barely reaching 6 months post-diagnosis. Such…”
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Cancer-associated fibroblast-derived annexin [A6.sup.+] extracellular vesicles support pancreatic cancer aggressiveness by Leca, Julie, Martinez, Sebastien, Lac, Sophie, Nigri, Jeremy, Secq, Veronique, Rubis, Marion, Bressy, Christian, Serge, Arnauld, Lavaut, Marie-Noelle, Dusetti, Nelson, Loncle, Celine, Roques, Julie, Pietrasz, Daniel, Bousquet, Corinne, Garcia, Stephane, Granjeaud, Samuel, Ouaissi, Mehdi, Bachet, Jean Baptiste, Brun, Christine, lovanna, Juan L, Zimmermann, Pascale, Vasseur, Sophie, Tomasini, Richard

“…The intratumoral microenvironment, or stroma, is of major importance in the pathobiology of pancreatic ductal adenocarcinoma (PDA), and specific conditions in…”
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