Search Results - "Jepson, G W"

Binding of Perfluorooctanoic Acid to Rat and Human Plasma Proteins by Han, Xing, Snow, Timothy A, Kemper, Raymond A, Jepson, Gary W

“…Perfluorooctanoic acid (PFOA) is a commercially important organic fluorochemical and is considered to have a long half-life in human blood. In this paper, PFOA…”
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Physiologically Based Modeling of Nonsteady State Dermal Absorption of Halogenated Methanes from an Aqueous Solution by Jepson, Gary W., McDougal, James N.

“…Dermal absorption of organic chemicals from aqueous solutions are a concern in both the workplace and the home. Organic chemicals are generally not very…”
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Predicting vehicle effects on the dermal absorption of halogenated methanes using physiologically based modeling by JEPSON, G. W, MCDOUGAL, J. N

“…Occupational and environmental settings present opportunities for humans to come into contact with a variety of chemicals via the dermal route. The chemicals…”
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PBPK MODELING OF SHORT-TERM (0 TO 5 MIN) HUMAN INHALATION EXPOSURES TO HALOGENATED HYDROCARBONS by Vinegar, A, Jepson, G W, Overton, J H

“…Allowable human exposure to Halons and Halon replacement chemicals is often regulated on the basis of cardiac sensitization potential. Exposure guidelines are…”
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Physiologically Based Pharmacokinetic Model for the Inhibition of Acetylcholinesterase by Organophosphate Esters by Gearhart, Jeffery M., Gary W. Jepson, Clewell, Harvey J., Andersen, Melvin E., Conolly, Rory B.

“…Organophosphate (OP) exposure can be lethal at high doses while lower doses may impair performance of critical tasks. The ability to predict such effects for…”
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Physiologically based pharmacokinetic and pharmacodynamic model for the inhibition of acetylcholinesterase by diisopropylfluorophosphate by Gearhart, J M, Jepson, G W, Clewell, 3rd, H J, Andersen, M E, Conolly, R B

“…Organophosphate (OP) exposure can be lethal at high doses while lower doses may impair performance of critical tasks. The ability to predict such effects for…”
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Subcellular Distribution and Protein Binding of Perfluorooctanoic Acid in Rat Liver and Kidney by Han, Xing, Kemper, R A, Jepson, G W

“…Perfluorooctanoic acid (PFOA) is an organic fluorochemical, and its elimination in rats is markedly sex-dependent. Liver and kidney are two primary tissues of…”
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A physiological pharmacokinetic model for dermal absorption of vapors in the rat by McDougal, J N, Jepson, G W, Clewell, 3rd, H J, MacNaughton, M G, Andersen, M E

“…Absorption of chemical vapors through the skin is a passive process that is not easily quantitated, but may be important in the assessment of health hazards in…”
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Dermal absorption of dihalomethane vapors by McDougal, J N, Jepson, G W, Clewell, 3rd, H J, Andersen, M E

“…The dermal absorption of dibromomethane (DBM) and bromochloromethane (BCM) vapors was studied in rats placed in a specially designed chamber incorporating…”
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Cardiac sensitization thresholds of halon replacement chemicals predicted in humans by physiologically-based pharmacokinetic modeling by Vinegar, A, Jepson, G W

“…Human exposure to halons and halon replacement chemicals is often regulated on the basis of cardiac sensitization potential. The dose-response data obtained…”
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SETTING SAFE ACUTE EXPOSURE LIMITS FOR HALON REPLACEMENT CHEMICALS USING PHYSIOLOGICALLY BASED PHARMACOKINETIC MODELING by Allen Vinegar, Gary W. Jepson, Mark Cisneros, Reva Rubenstein, William J. Brock

“…Most proposed replacements for Halon 1301 as a fire suppressant are halogenated hydrocarbons. The acute toxic endpoint of concern for these agents is cardiac…”
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A partition coefficient determination method for nonvolatile chemicals in biological tissues by Jepson, G W, Hoover, D K, Black, R K, McCafferty, J D, Mahle, D A, Gearhart, J M

“…Partition or distribution coefficients are critical elements in efforts designed to describe the uptake, distribution, biotransformation, and excretion of…”
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Simulated blood levels of CF3I in personnel exposed during its release from an F-15 jet engine nacelle and during intentional inhalation by Vinegar, A, Jepson, G W, Hammann, S J, Harper, G, Dierdorf, D S, Overton, J H

“…Of the agents under consideration for protecting unoccupied areas from fire, CF3I (trifluoroiodomethane) has physicochemical properties that give it potential…”
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Dermal absorption of organic chemical vapors in rats and humans by McDougal, J N, Jepson, G W, Clewell, 3rd, H J, Gargas, M L, Andersen, M E

“…Quantitation of chemical vapor penetration through skin is necessary for assessment of health hazards involved in some occupational environments. Information…”
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Determination of skin:air partition coefficients for volatile chemicals: experimental method and applications by Mattie, D R, Bates, Jr, G D, Jepson, G W, Fisher, J W, McDougal, J N

“…The partition coefficient (PC) of a chemical in skin is an indicator of the capacity for a chemical in the skin and may reflect the rate at which a chemical…”
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Biotransformation of 2,3,3,3-tetrafluoropropene (HFO-1234yf) by Schuster, Paul, Bertermann, Rüdiger, Snow, Timothy A., Han, Xing, Rusch, George M., Jepson, Gary W., Dekant, Wolfgang

“…2,3,3,3-Tetrafluoropropene (HFO-1234yf) is a non-ozone-depleting fluorocarbon replacement with a low global warming potential which has been developed as…”
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Inflammatory damage to skin by prolonged contact with 1,2-dichlorobenzene and chloropentafluorobenzene by McDougal, James N., Grabau, John H., Dong, Lily, Mattie, David R., Jepson, Gary W.

“…Skin samples from Fischer‐344 rats and Hartley guinea pigs exposed dermally to 1,2‐dichlorobenzene (DCB) and chloropentafluorobenzene (CPFB) for up to 4 h were…”
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Physiologically based pharmacokinetic model for the inhibition of acetylcholinesterase by organophosphate esters by Gearhart, J M, Jepson, G W, Clewell, HJ, Andersen, ME, Conolly, R B

“…Organophosphate (OP) exposure can be lethal at high doses while lower doses may impair performance of critical tasks. The ability to predict such effects for…”
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