Search Results - "Jepsen, Karl J."

Establishing Biomechanical Mechanisms in Mouse Models: Practical Guidelines for Systematically Evaluating Phenotypic Changes in the Diaphyses of Long Bones by Jepsen, Karl J, Silva, Matthew J, Vashishth, Deepak, Guo, X Edward, van der Meulen, Marjolein CH

“…ABSTRACT Mice are widely used in studies of skeletal biology, and assessment of their bones by mechanical testing is a critical step when evaluating the…”
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Guidelines for assessment of bone microstructure in rodents using micro–computed tomography by Bouxsein, Mary L, Boyd, Stephen K, Christiansen, Blaine A, Guldberg, Robert E, Jepsen, Karl J, Müller, Ralph

“…Use of high‐resolution micro–computed tomography (µCT) imaging to assess trabecular and cortical bone morphology has grown immensely. There are several…”
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Region-specific variation in the properties of skeletal adipocytes reveals regulated and constitutive marrow adipose tissues by Scheller, Erica L., Doucette, Casey R., Learman, Brian S., Cawthorn, William P., Khandaker, Shaima, Schell, Benjamin, Wu, Brent, Ding, Shi-Ying, Bredella, Miriam A., Fazeli, Pouneh K., Khoury, Basma, Jepsen, Karl J., Pilch, Paul F., Klibanski, Anne, Rosen, Clifford J., MacDougald, Ormond A.

“…Marrow adipose tissue (MAT) accumulates in diverse clinical conditions but remains poorly understood. Here we show region-specific variation in MAT adipocyte…”
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Functional Interactions Among Morphologic and Tissue Quality Traits Define Bone Quality by Jepsen, Karl J.

“…Background Advances in diagnostic and treatment regimens that aim to reduce fracture incidence will benefit from a better understanding of how bone morphology…”
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The relationship between whole bone stiffness and strength is age and sex dependent by Patton, Daniella M., Bigelow, Erin M.R., Schlecht, Stephen H., Kohn, David H., Bredbenner, Todd L., Jepsen, Karl J.

“…Accurately estimating whole bone strength is critical for identifying individuals that may benefit from prophylactic treatments aimed at reducing fracture…”
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Involvement of the Toll-like receptor 4 pathway and use of TNF-α antagonists for treatment of the mucopolysaccharidoses by Simonaro, Calogera M, Ge, Yi, Eliyahu, Efrat, He, Xingxuan, Jepsen, Karl J, Schuchman, Edward H

“…Enzyme replacement therapy is currently available for three of the mucopolysaccharidoses (MPSs) but has limited effects on the skeletal lesions. We…”
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Type XII collagen regulates osteoblast polarity and communication during bone formation by Izu, Yayoi, Sun, Mei, Zwolanek, Daniela, Veit, Guido, Williams, Valerie, Cha, Byeong, Jepsen, Karl J, Koch, Manuel, Birk, David E

“…Differentiated osteoblasts are polarized in regions of bone deposition, demonstrate extensive cell interaction and communication, and are responsible for bone…”
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Genetic architecture of complex traits: Large phenotypic effects and pervasive epistasis by Shao, Haifeng, Burrage, Lindsay C, Sinasac, David S, Hill, Annie E, Ernest, Sheila R, O'Brien, William, Courtland, Hayden-William, Jepsen, Karl J, Kirby, Andrew, Kulbokas, E.J, Daly, Mark J, Broman, Karl W, Lander, Eric S, Nadeau, Joseph H

“…The genetic architecture of complex traits underlying physiology and disease in most organisms remains elusive. We still know little about the number of genes…”
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How Does Bone Strength Compare Across Sex, Site, and Ethnicity? by Schlecht, Stephen H., Bigelow, Erin M. R., Jepsen, Karl J.

“…Background The risk of fragility fractures in the United States is approximately 2.5 times greater among black and white women compared with their male…”
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Differential changes in bone strength of two inbred mouse strains following administration of a sclerostin-neutralizing antibody during growth by Mathis, Noah J, Adaniya, Emily N, Smith, Lauren M, Robling, Alexander G, Jepsen, Karl J, Schlecht, Stephen H

“…Administration of sclerostin-neutralizing antibody (Scl-Ab) treatment has been shown to elicit an anabolic bone response in growing and adult mice. Prior work…”
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Anti-TNF-alpha therapy enhances the effects of enzyme replacement therapy in rats with mucopolysaccharidosis type VI by Eliyahu, Efrat, Wolfson, Theodore, Ge, Yi, Jepsen, Karl J, Schuchman, Edward H, Simonaro, Calogera M

“…Although enzyme replacement therapy (ERT) is available for several lysosomal storage disorders, the benefit of this treatment to the skeletal system is very…”
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Subrupture tendon fatigue damage by Fung, David T., Wang, Vincent M., Laudier, Damien M., Shine, Jean H., Basta-Pljakic, Jelena, Jepsen, Karl J., Schaffler, Mitchell B., Flatow, Evan L.

“…The mechanical and microstructural bases of tendon fatigue, by which damage accumulates and contributes to degradation, are poorly understood. To investigate…”
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The mortality burden of non-trauma fracture for adults with cerebral palsy by Whitney, Daniel G., Bell, Sarah, Hurvitz, Edward A., Peterson, Mark D., Caird, Michelle S., Jepsen, Karl J.

“…Individuals with cerebral palsy (CP) manifest skeletal fragility problems early in life, are vulnerable to non-trauma fracture (NTFx), and have a high burden…”
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The respiratory disease burden of non-traumatic fractures for adults with cerebral palsy by Etter, Jonathan P., Kannikeswaran, Sanjana, Hurvitz, Edward A., Peterson, Mark D., Caird, Michelle S., Jepsen, Karl J., Whitney, Daniel G.

“…Individuals with cerebral palsy (CP) are vulnerable to non-trauma fracture (NTFx) and premature mortality due to respiratory disease (RD); however, very little…”
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Structural and mechanical effects of in vivo fatigue damage induction on murine tendon by Sereysky, Jedd B., Andarawis-Puri, Nelly, Jepsen, Karl J., Flatow, Evan L.

“…The purpose of this study was to develop and validate an in vivo mouse model of tendon fatigue and use this model to investigate and quantify the physical…”
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Elevated serum levels of IGF‐1 are sufficient to establish normal body size and skeletal properties even in the absence of tissue IGF‐1 by Elis, Sebastien, Courtland, Hayden‐William, Wu, Yingjie, Rosen, Clifford J, Sun, Hui, Jepsen, Karl J, Majeska, Robert J, Yakar, Shoshana

“…Use of recombinant insulin‐like growth factor 1 (IGF‐1) as a treatment for primary IGF‐1 deficiency in children has become increasingly common. When untreated,…”
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The transcriptome of fracture healing defines mechanisms of coordination of skeletal and vascular development during endochondral bone formation by Grimes, Rachel, Jepsen, Karl J, Fitch, Jennifer L, Einhorn, Thomas A, Gerstenfeld, Louis C

“…Fractures initiate one round of endochondral bone formation in which callus cells differentiate in a synchronous manner that temporally phenocopies the spatial…”
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Relationship Between Bone Morphology and Bone Quality in Male Tibias: Implications for Stress Fracture Risk by Tommasini, Steven M, Nasser, Philip, Schaffler, Mitchell B, Jepsen, Karl J

“…Biomechanical properties were assessed from the tibias of 17 adult males 17‐46 years of age. Tissue‐level mechanical properties varied with bone size. Narrower…”
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Three-dimensional Reconstruction of Fracture Callus Morphogenesis by Gerstenfeld, Louis C, Alkhiary, Yaser M, Krall, Elizabeth A, Nicholls, Fred H, Stapleton, Stephanie N, Fitch, Jennifer L, Bauer, Megan, Kayal, Rayyan, Graves, Dana T, Jepsen, Karl J, Einhorn, Thomas A

“…Rat and mouse femur and tibia fracture calluses were collected over various time increments of healing. Serial sections were produced at spatial segments…”
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Serum IGF-1 affects skeletal acquisition in a temporal and compartment-specific manner by Courtland, Hayden-William, Elis, Sebastien, Wu, Yingjie, Sun, Hui, Rosen, Clifford J, Jepsen, Karl J, Yakar, Shoshana

“…Insulin-like growth factor-1 (IGF-1) plays a critical role in the development of the growing skeleton by establishing both longitudinal and transverse bone…”
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