Search Results - "Jepps, Thomas A"

Cyclic AMP-Dependent Regulation of Kv7 Voltage-Gated Potassium Channels by van der Horst, Jennifer, Greenwood, Iain A, Jepps, Thomas A

“…Voltage-gated Kv7 potassium channels, encoded by genes, have major physiological impacts cardiac myocytes, neurons, epithelial cells, and smooth muscle cells…”
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Suppression of smooth muscle cell inflammation by myocardin-related transcription factors involves inactivation of TANK-binding kinase 1 by Bankell, Elisabeth, Liu, Li, van der Horst, Jennifer, Rippe, Catarina, Jepps, Thomas A., Nilsson, Bengt-Olof, Swärd, Karl

“…Myocardin-related transcription factors (MRTFs: myocardin/ MYOCD , MRTF-A/ MRTFA , and MRTF-B/ MRTFB ) suppress production of pro-inflammatory cytokines and…”
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Editorial: Kv7 Channels: Structure, Physiology, and Pharmacology by Jepps, Thomas A, Barrese, Vincenzo, Miceli, Francesco

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TMEM16A is implicated in the regulation of coronary flow and is altered in hypertension by Askew Page, Henry R., Dalsgaard, Thomas, Baldwin, Samuel N., Jepps, Thomas A., Povstyan, Oleksandr, Olesen, Søren P., Greenwood, Iain A.

“…Background and Purpose Coronary artery disease leads to ischaemic heart disease and ultimately myocardial infarction. Thus, it is important to determine the…”
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Cycling matters: Sex hormone regulation of vascular potassium channels by Baldwin, Samuel N, Jepps, Thomas A, Greenwood, Iain A

“…Sex hormones and the reproductive cycle (estrus in rodents and menstrual in humans) have a known impact on arterial function. In spite of this, sex hormones…”
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Medicinal plant rosemary relaxes blood vessels by activating vascular smooth muscle KCNQ channels by Manville, Rían W., Baldwin, Samuel N., Eriksen, Emil Ørnberg, Jepps, Thomas A., Abbott, Geoffrey W.

“…The evergreen plant rosemary (Salvia rosmarinus) has been employed medicinally for centuries as a memory aid, analgesic, spasmolytic, vasorelaxant and…”
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Acetaminophen (Paracetamol) Metabolites Induce Vasodilation and Hypotension by Activating Kv7 Potassium Channels Directly and Indirectly by van der Horst, Jennifer, Manville, Rian W., Hayes, Katie, Thomsen, Morten B., Abbott, Geoffrey W., Jepps, Thomas A.

“…OBJECTIVE:Intravenous acetaminophen/paracetamol (APAP) is well documented to cause hypotension. Since the patients receiving intravenous APAP are usually…”
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Contribution of Kv7 channels to natriuretic peptide mediated vasodilation in normal and hypertensive rats by Stott, Jennifer B, Barrese, Vincenzo, Jepps, Thomas A, Leighton, Emma V, Greenwood, Iain A

“…The Kv7 family of voltage-gated potassium channels are expressed within the vasculature where they are key regulators of vascular tone and mediate cAMP-linked…”
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KCNQ5 Potassium Channel Activation Underlies Vasodilation by Tea by Redford, Kaitlyn E, Rognant, Salomé, Jepps, Thomas A, Abbott, Geoffrey W

“…Tea, produced from the evergreen Camellia sinensis, has reported therapeutic properties against multiple pathologies, including hypertension. Although some…”
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Kcne4 Deletion Sex-Dependently Alters Vascular Reactivity by Abbott, Geoffrey W, Jepps, Thomas A

“…Voltage-gated potassium (Kv) channels formed by Kv7 (KCNQ) α-subunits are recognized as crucial for vascular smooth muscle function, in addition to their…”
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Contribution of Kv7 Channels to Basal Coronary Flow and Active Response to Ischemia by KHANAMIRI, Saereh, SOLTYSINSKA, Ewa, JEPPS, Thomas A, BENTZEN, Bo H, CHADHA, Preet S, SCHMITT, Nicole, GREENWOOD, Iain A, OLESEN, Søren-Peter

“…The goal of the present study was to determine the role of KCNQ-encoded Kv channels (Kv7 channels) in the passive and active regulation of coronary flow in…”
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The microtubule network enables Src kinase interaction with the Na,K-ATPase to generate Ca2+ flashes in smooth muscle cells by Rognant, Salomé, Kravtsova, Violetta V., Bouzinova, Elena V., Melnikova, Elizaveta V., Krivoi, Igor I., Pierre, Sandrine V., Aalkjaer, Christian, Jepps, Thomas A., Matchkov, Vladimir V.

“…Background: Several local Ca 2+ events are characterized in smooth muscle cells. We have previously shown that an inhibitor of the Na,K-ATPase, ouabain induces…”
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Kcne4 deletion sex dependently inhibits the RISK pathway response and exacerbates hepatic ischemia-reperfusion injury in mice by Hu, Zhaoyang, Jepps, Thomas A, Zhou, Leng, Liu, Jin, Li, Mufeng, Abbott, Geoffrey W

“…Activation of antiapoptotic signaling cascades, such as the reperfusion injury salvage kinase (RISK) and survivor activating factor enhancement (SAFE)…”
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Expression and function of the K+ channel KCNQ genes in human arteries by Ng, Fu Liang, Davis, Alison J, Jepps, Thomas A, Harhun, Maksym I, Yeung, Shuk Yin, Wan, Andrew, Reddy, Marcus, Melville, David, Nardi, Antonio, Khong, Teck K, Greenwood, Iain A

“…BACKGROUND AND PURPOSE KCNQ‐encoded voltage‐gated potassium channels (Kv7) have recently been identified as important anti‐constrictor elements in rodent blood…”
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Expression profile and protein translation of TMEM16A in murine smooth muscle by Davis, Alison J, Forrest, Abigail S, Jepps, Thomas A, Valencik, Maria L, Wiwchar, Michael, Singer, Cherie A, Sones, William R, Greenwood, Iain A, Leblanc, Normand

“…Recently, overexpression of the genes TMEM16A and TMEM16B has been shown to produce currents qualitatively similar to native Ca(2+)-activated Cl(-) currents…”
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Pharmacological dissection of Kv7.1 channels in systemic and pulmonary arteries by Chadha, Preet S, Zunke, Friederike, Davis, Alison J, Jepps, Thomas A, Linders, Joannes TM, Schwake, Michael, Towart, Rob, Greenwood, Iain A

“…BACKGROUND AND PURPOSE The aim of this study was to characterize the functional impact of KCNQ1‐encoded voltage‐dependent potassium channels (Kv7.1) in the…”
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Vascular smooth muscle-specific YAP/TAZ deletion triggers aneurysm development in mouse aorta by Arévalo Martínez, Marycarmen, Ritsvall, Olivia, Bastrup, Joakim A, Celik, Selvi, Jakobsson, Gabriel, Daoud, Fatima, Winqvist, Christopher, Aspberg, Anders, Rippe, Catarina, Maegdefessel, Lars, Schiopu, Alexandru, Jepps, Thomas A, Holmberg, Johan, Swärd, Karl, Albinsson, Sebastian

“…Inadequate adaption to mechanical forces, including blood pressure, contributes to development of arterial aneurysms. Recent studies have pointed to a…”
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Polymodal K+ channel modulation contributes to dual analgesic and anti-inflammatory actions of traditional botanical medicines by Manville, Rían W., Yoshimura, Ryan F., Yeromin, Andriy V., Hogenkamp, Derk, van der Horst, Jennifer, Zavala, Angel, Chinedu, Sonia, Arena, Grey, Lasky, Emma, Fisher, Mark, Tracy, Christopher R., Othy, Shivashankar, Jepps, Thomas A., Cahalan, Michael D., Abbott, Geoffrey W.

“…Pain and inflammation contribute immeasurably to reduced quality of life, yet modern analgesic and anti-inflammatory therapeutics can cause dependence and side…”
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The impact of an atrial septal defect on the progression of atrial tachypacing-induced atrial fibrillation in a Danish Landrace pig: A case report by Saljic, Arnela, Norup Hertel, Julie, Leonhardt, Caroline, Dalgas Nissen, Sarah, Dobrev, Dobromir, Jepps, Thomas A., Jespersen, Thomas, Michael Sattler, Stefan

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Kv7 channel trafficking by the microtubule network in vascular smooth muscle by Jepps, Thomas A.

“…Abstract In arterial smooth muscle cells, changes in availability of integral membrane proteins influence the regulation of blood flow and blood pressure,…”
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