Search Results - "Jentsch, James David"

In the blink of an eye: relating positive-feedback sensitivity to striatal dopamine D2-like receptors through blink rate by Groman, Stephanie M, James, Alex S, Seu, Emanuele, Tran, Steven, Clark, Taylor A, Harpster, Sandra N, Crawford, Maverick, Burtner, Joanna Lee, Feiler, Karen, Roth, Robert H, Elsworth, John D, London, Edythe D, Jentsch, James David

“…For >30 years, positron emission tomography (PET) has proven to be a powerful approach for measuring aspects of dopaminergic transmission in the living human…”
Get full text

Dopamine D2/D3 receptors play a specific role in the reversal of a learned visual discrimination in monkeys by LEE, Buyean, GROMAN, Stephanie, LONDON, Edythe D, JENTSCH, James David

“…Converging evidence supports a role for mesocorticolimbic dopaminergic systems in a subject's ability to shift behavior in response to changing stimulus-reward…”
Get full text

Dysbindin Modulates Prefrontal Cortical Glutamatergic Circuits and Working Memory Function in Mice by JENTSCH, James David, TRANTHAM-DAVIDSON, Heather, JAIRL, Corey, TINSLEY, Matthew, CANNON, Tyrone D, LAVIN, Antonieta

“…Behavioral genetic studies of humans have associated variation in the DTNBP1 gene with schizophrenia and its cognitive deficit phenotypes. The protein coded…”
Get full text

Monoamine Levels Within the Orbitofrontal Cortex and Putamen Interact to Predict Reversal Learning Performance by Groman, Stephanie M, James, Alex S, Seu, Emanuele, Crawford, Maverick A, Harpster, Sandra N, Jentsch, James David

“…Background The compulsive and inflexible behaviors that are present in many psychiatric disorders, particularly behavioral addictions and obsessive-compulsive…”
Get full text

Reward, interrupted: Inhibitory control and its relevance to addictions by Jentsch, James David, Pennington, Zachary T.

“…There are broad individual differences in the ability to voluntarily and effortfully suppress motivated, reward-seeking behaviors, and this review presents the…”
Get full text

In the Blink of an Eye: Relating Positive-Feedback Sensitivity to Striatal Dopamine D 2 -Like Receptors through Blink Rate by Groman, Stephanie M., James, Alex S., Seu, Emanuele, Tran, Steven, Clark, Taylor A., Harpster, Sandra N., Crawford, Maverick, Burtner, Joanna Lee, Feiler, Karen, Roth, Robert H., Elsworth, John D., London, Edythe D., Jentsch, James David

“…For >30 years, positron emission tomography (PET) has proven to be a powerful approach for measuring aspects of dopaminergic transmission in the living human…”
Get full text

Targeted expression of μ-opioid receptors in a subset of striatal direct-pathway neurons restores opiate reward by Cui, Yijun, Ostlund, Sean B, James, Alex S, Park, Chang Sin, Ge, Weihong, Roberts, Kristofer W, Mittal, Nitish, Murphy, Niall P, Cepeda, Carlos, Kieffer, Brigitte L, Levine, Michael S, Jentsch, James David, Walwyn, Wendy M, Sun, Yi E, Evans, Christopher J, Maidment, Nigel T, Yang, X William

“…μ-opioid receptor (MOR) was previously shown to be necessary for opiate reward, analgesia and dependence. To better understand the specific anatomical and cell…”
Get full text

The future of translational research on alcohol use disorder by Ray, Lara A., Grodin, Erica N., Leggio, Lorenzo, Bechtholt, Anita J., Becker, Howard, Feldstein Ewing, Sarah W., Jentsch, James David, King, Andrea C., Mason, Barbara J., O'Malley, Stephanie, MacKillop, James, Heilig, Markus, Koob, George F.

“…In March 2019, a scientific meeting was held at the University of California, Los Angeles (UCLA) Luskin Center to discuss approaches to expedite the…”
Get full text

Heritable variation in locomotion, reward sensitivity and impulsive behaviors in a genetically diverse inbred mouse panel by Bailey, Lauren S., Bagley, Jared R., Dodd, Rainy, Olson, Ashley, Bolduc, Mikayla, Philip, Vivek M., Reinholdt, Laura G., Sukoff Rizzo, Stacey J., Tarantino, Lisa, Gagnon, Leona, Chesler, Elissa J., Jentsch, James David

“…Drugs of abuse, including alcohol and stimulants like cocaine, produce effects that are subject to individual variability, and genetic variation accounts for…”
Get full text

Methamphetamine-induced increases in putamen gray matter associate with inhibitory control by Groman, Stephanie M., Morales, Angelica M., Lee, Buyean, London, Edythe D., Jentsch, James David

“…Rationale Problematic drug use is associated with difficulty in exerting self-control over behaviors, and this difficulty may be a consequence of atypical…”
Get full text

Behavioral Characteristics and Neural Mechanisms Mediating Performance in a Rodent Version of the Balloon Analog Risk Task by JENTSCH, James David, WOODS, Jason A, GROMAN, Stephanie M, SEU, Emanuele

“…The tendency for some individuals to partake in high-risk behaviors (eg, substance abuse, gambling, risky sexual activities) is a matter of great public health…”
Get full text

Opioid self-administration results in cell-type specific adaptations of striatal medium spiny neurons by James, Alex S., Chen, Jane Y., Cepeda, Carlos, Mittal, Nitish, Jentsch, James David, Levine, Michael S., Evans, Christopher J., Walwyn, Wendy

“…•We examined the effect of repeated contingent opioid exposure on striatal medium spiny neurons (MSNs) in D1- and D2-GFP expressing mice.•Mice were trained to…”
Get full text

In the Blink of an Eye: Relating Positive-Feedback Sensitivity to Striatal Dopamine D sub(2)-Like Receptors through Blink Rate by Groman, Stephanie M, James, Alex S, Seu, Emanuele, Tran, Steven, Clark, Taylor A, Harpster, Sandra N, Crawford, Maverick, Burtner, Joanna Lee, Feiler, Karen, Roth, Robert H, Elsworth, John D, London, Edythe D, Jentsch, James David

“…For >30 years, positron emission tomography (PET) has proven to be a powerful approach for measuring aspects of dopaminergic transmission in the living human…”
Get full text

Compromised NMDA/Glutamate Receptor Expression in Dopaminergic Neurons Impairs Instrumental Learning, But Not Pavlovian Goal Tracking or Sign Tracking by James, Alex S, Pennington, Zachary T, Tran, Phu, Jentsch, James David

“…Two theories regarding the role for dopamine neurons in learning include the concepts that their activity serves as a (1) mechanism that confers incentive…”
Get full text

Targeted expression of [mu]-opioid receptors in a subset of striatal direct-pathway neurons restores opiate reward by Cui, Yijun, Ostlund, Sean B, James, Alex S, Park, Chang Sin, Ge, Weihong, Roberts, Kristofer W, Mittal, Nitish, Murphy, Niall P, Cepeda, Carlos, Kieffer, Brigitte L, Levine, Michael S, Jentsch, James David, Walwyn, Wendy M, Sun, Yi E, Evans, Christopher J, Maidment, Nigel T, Yang, X William

“…μ-opioid receptors (MORs) are necessary for the analgesic and addictive effects of opioids such as morphine, but the MOR-expressing neuronal populations that…”
Get full text

Compromised NMDA/Glutamate Receptor Expression in Dopaminergic Neurons Impairs Instrumental Learning, But Not Pavlovian Goal Tracking or Sign Tracking1,2,3 by James, Alex S., Pennington, Zachary T., Tran, Phu, Jentsch, James David

“…Behavior is shaped to a dramatic degree by the occurrence of rewards, through both pavlovian and instrumental conditioning processes; these mechanisms give…”
Get full text

Neurochemical substrates of cognitive dysfunction produced by the psychotomimetic drug phencyclidine by Jentsch, James David

“…Administration of non-competitive NMDA/glutamate receptor antagonists, such as phencyclidine (PCP) and ketamine, to humans induces a broad range of…”
Get full text

Neurochemical substrates of cognitive dysfunction produced by the psychotomimetic drug phencyclidine by Jentsch, James David

“…Administration of non-competitive NMDA/glutamate receptor antagonists, such as phencyclidine (PCP) and ketamine, to humans induces a broad range of…”
Get full text