Search Results - "Jensen, Trine I"

CRISPR-Cas-mediated transcriptional modulation: The therapeutic promises of CRISPRa and CRISPRi by Bendixen, Louise, Jensen, Trine I., Bak, Rasmus O.

“…The CRISPR-Cas system is commonly known for its ability to cleave DNA in a programmable manner, which has democratized gene editing and facilitated recent…”
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Argonaute-associated short introns are a novel class of gene regulators by Hansen, Thomas B., Venø, Morten T., Jensen, Trine I., Schaefer, Anne, Damgaard, Christian K., Kjems, Jørgen

“…MicroRNAs (miRNAs) are short (∼22 nucleotides) regulators of gene expression acting by direct base pairing to 3′-UTR target sites in messenger RNAs. Mature…”
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Enrichment of transgene integrations by transient CRISPR activation of a silent reporter gene by Mikkelsen, Nanna S., Hernandez, Sabina S., Jensen, Trine I., Schneller, Jessica L., Bak, Rasmus O.

“…CRISPR-Cas-mediated site-specific integration of transgenes by homology-directed repair (HDR) is challenging, especially in primary cells, where inferior…”
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Natural RNA circles function as efficient microRNA sponges by Hansen, Thomas B., Jensen, Trine I., Clausen, Bettina H., Bramsen, Jesper B., Finsen, Bente, Damgaard, Christian K., Kjems, Jørgen

“…A natural circular RNA termed ciRS-7 is shown to function as a negative regulator of microRNA; ciRS-7 acts as an efficient sponge for the microRNA miR-7, and…”
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SAM68 directs STING signaling to apoptosis in macrophages by van der Horst, Demi, Kurmasheva, Naziia, Marqvorsen, Mikkel H. S., Assil, Sonia, Rahimic, Anna H. F., Kollmann, Christoph F., Silva da Costa, Leandro, Wu, Qi, Zhao, Jian, Cesari, Eleonora, Iversen, Marie B., Ren, Fanghui, Jensen, Trine I., Narita, Ryo, Schack, Vivien R., Zhang, Bao-cun, Bak, Rasmus O., Sette, Claudio, Fenton, Robert A., Mikkelsen, Jacob G., Paludan, Søren R., Olagnier, David

“…DNA is a danger signal sensed by cGAS to engage signaling through STING to activate innate immune functions. The best-studied downstream responses to STING…”
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Therapeutic gene editing in haematological disorders with CRISPR/Cas9 by Jensen, Trine I., Axelgaard, Esben, Bak, Rasmus O.

“…Summary The Clustered Regularly Interspaced Short Palindromic Repeats (CRISPR)/CRISPR‐associated (Cas)9 platform offers an efficient way of making precise…”
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Targeted regulation of transcription in primary cells using CRISPRa and CRISPRi by Jensen, Trine I, Mikkelsen, Nanna S, Gao, Zongliang, Foßelteder, Johannes, Pabst, Gabriel, Axelgaard, Esben, Laustsen, Anders, König, Saskia, Reinisch, Andreas, Bak, Rasmus O

“…Targeted transcriptional activation or interference can be induced with the CRISPR-Cas9 system (CRISPRa/CRISPRi) using nuclease-deactivated Cas9 fused to…”
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CD5 expression by dendritic cells directs T cell immunity and sustains immunotherapy responses by He, Mingyu, Roussak, Kate, Ma, Feiyang, Borcherding, Nicholas, Garin, Vince, White, Mike, Schutt, Charles, Jensen, Trine I, Zhao, Yun, Iberg, Courtney A, Shah, Kairav, Bhatia, Himanshi, Korenfeld, Daniel, Dinkel, Sabrina, Gray, Judah, Ulezko Antonova, Alina, Ferris, Stephen, Donermeyer, David, Lindestam Arlehamn, Cecilia, Gubin, Matthew M, Luo, Jingqin, Gorvel, Laurent, Pellegrini, Matteo, Sette, Alessandro, Tung, Thomas, Bak, Rasmus, Modlin, Robert L, Fields, Ryan C, Schreiber, Robert D, Allen, Paul M, Klechevsky, Eynav

“…The induction of proinflammatory T cells by dendritic cell (DC) subtypes is critical for antitumor responses and effective immune checkpoint blockade (ICB)…”
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442-E A novel targeted, type I interferon producing, innate lymphocyte therapy with potent anti-tumor activity by Laustsen, Anders, Bjerg, Tobias W, Hansen, Aida S, Jæhger, Ditte, Jensen, Trine I, Trempenau, Mette-Louise, Jensen, Kasper M, Haahr, Nicolai O, Rosendal, Marcus N, Vejlebo, Jonas B, Diaconu, Iulia, Bak, Rasmus O, Jakobsen, Martin R

“…BackgroundPlasmacytoid Dendritic Cells (pDCs) - sometimes referred to as type I interferon producing innate lymphocyte cells - are known as a master regulator…”
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