Search Results - "Jensen, Torben Heick"

The multitasking polyA tail: nuclear RNA maturation, degradation and export by Tudek, Agnieszka, Lloret-Llinares, Marta, Jensen, Torben Heick

“…A polyA (pA) tail is an essential modification added to the 3′ ends of a wide range of RNAs at different stages of their metabolism. Here, we describe the main…”
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Identification of a Nuclear Exosome Decay Pathway for Processed Transcripts by Meola, Nicola, Domanski, Michal, Karadoulama, Evdoxia, Chen, Yun, Gentil, Coline, Pultz, Dennis, Vitting-Seerup, Kristoffer, Lykke-Andersen, Søren, Andersen, Jens S., Sandelin, Albin, Jensen, Torben Heick

“…The RNA exosome is fundamental for the degradation of RNA in eukaryotic nuclei. Substrate targeting is facilitated by its co-factor Mtr4p/hMTR4, which links to…”
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The Human Nuclear Exosome Targeting Complex Is Loaded onto Newly Synthesized RNA to Direct Early Ribonucleolysis by Lubas, Michal, Andersen, Peter Refsing, Schein, Aleks, Dziembowski, Andrzej, Kudla, Grzegorz, Jensen, Torben Heick

“…The RNA exosome complex constitutes the major nuclear eukaryotic 3′-5′ exonuclease. Outside of nucleoli, the human nucleoplasmic exosome is directed to some of…”
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Transcription start site analysis reveals widespread divergent transcription in D. melanogaster and core promoter-encoded enhancer activities by Rennie, Sarah, Dalby, Maria, Lloret-Llinares, Marta, Bakoulis, Stylianos, Dalager Vaagensø, Christian, Heick Jensen, Torben, Andersson, Robin

“…Abstract Mammalian gene promoters and enhancers share many properties. They are composed of a unified promoter architecture of divergent transcripton…”
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Nuclear stability and transcriptional directionality separate functionally distinct RNA species by Andersson, Robin, Refsing Andersen, Peter, Valen, Eivind, Core, Leighton J., Bornholdt, Jette, Boyd, Mette, Heick Jensen, Torben, Sandelin, Albin

“…Mammalian genomes are pervasively transcribed, yielding a complex transcriptome with high variability in composition and cellular abundance. Although recent…”
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Interaction Profiling Identifies the Human Nuclear Exosome Targeting Complex by Lubas, Michal, Christensen, Marianne S., Kristiansen, Maiken S., Domanski, Michal, Falkenby, Lasse G., Lykke-Andersen, Søren, Andersen, Jens S., Dziembowski, Andrzej, Jensen, Torben Heick

“…The RNA exosome is a conserved degradation machinery, which obtains full activity only when associated with cofactors. The most prominent activator of the…”
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The MTR4 helicase recruits nuclear adaptors of the human RNA exosome using distinct arch-interacting motifs by Lingaraju, Mahesh, Johnsen, Dennis, Schlundt, Andreas, Langer, Lukas M., Basquin, Jérôme, Sattler, Michael, Heick Jensen, Torben, Falk, Sebastian, Conti, Elena

“…The nuclear exosome and its essential co-factor, the RNA helicase MTR4, play crucial roles in several RNA degradation pathways. Besides unwinding RNA…”
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Mapping domains of ARS2 critical for its RNA decay capacity by Melko, Mireille, Winczura, Kinga, Rouvière, Jérôme Olivier, Oborská-Oplová, Michaela, Andersen, Pia K, Heick Jensen, Torben

“…Abstract ARS2 is a conserved protein centrally involved in both nuclear RNA productive and destructive processes. To map features of ARS2 promoting RNA decay,…”
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Structural basis for competitive binding of productive and degradative co-transcriptional effectors to the nuclear cap-binding complex by Dubiez, Etienne, Pellegrini, Erika, Finderup Brask, Maja, Garland, William, Foucher, Anne-Emmanuelle, Huard, Karine, Heick Jensen, Torben, Cusack, Stephen, Kadlec, Jan

“…The nuclear cap-binding complex (CBC) coordinates co-transcriptional maturation, transport, or degradation of nascent RNA polymerase II (Pol II) transcripts…”
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The Nuclear PolyA-Binding Protein Nab2p Is Essential for mRNA Production by Schmid, Manfred, Olszewski, Pawel, Pelechano, Vicent, Gupta, Ishaan, Steinmetz, Lars M., Jensen, Torben Heick

“…Polyadenylation of mRNA is a key step in eukaryotic gene expression. However, despite the major impact of poly(A) tails on mRNA metabolism, the precise roles…”
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Controlling nuclear RNA levels by Schmid, Manfred, Jensen, Torben Heick

“…RNA turnover is an integral part of cellular RNA homeostasis and gene expression regulation. Whereas the cytoplasmic control of protein-coding mRNA is often…”
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Dealing with Pervasive Transcription by Jensen, Torben Heick, Jacquier, Alain, Libri, Domenico

“…Eukaryotic genomes are pervasively transcribed. However, it is unclear how many newly found RNAs have functions and how many are byproducts of functional, or…”
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Nuclear Retention Prevents Premature Cytoplasmic Appearance of mRNA by Kallehauge, Thomas Beuchert, Robert, Marie-Cécile, Bertrand, Edouard, Jensen, Torben Heick

“…In S. cerevisiae cells debilitated in mRNA nuclear export, transcripts are retained in nuclear foci (“dots”). The ultimate fate of dot-mRNA has remained…”
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Nuclear sorting of RNA by Garland, William, Jensen, Torben Heick

“…The majority of the mammalian genome is transcribed by RNA polymerase II, yielding a vast amount of noncoding RNA (ncRNA) in addition to the standard…”
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Assigning function to an unexplored Integrator module by Garland, William, Rouvière, Jérôme O, Heick Jensen, Torben

“…In this issue of Molecular Cell, Razew et al. and Sabath et al. assign function to an unexplored module of the Integrator (INT) complex, expanding the toolbox…”
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Escaping nuclear decay: the significance of mRNA export for gene expression by Tudek, Agnieszka, Schmid, Manfred, Jensen, Torben Heick

“…In this perspective, we discuss the regulatory impact of nuclear RNA export and decay on messenger RNA (mRNA) functionality. It is well established that…”
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Human nonsense-mediated RNA decay initiates widely by endonucleolysis and targets snoRNA host genes by Lykke-Andersen, Søren, Chen, Yun, Ardal, Britt R, Lilje, Berit, Waage, Johannes, Sandelin, Albin, Jensen, Torben Heick

“…Eukaryotic RNAs with premature termination codons (PTCs) are eliminated by nonsense-mediated decay (NMD). While human nonsense RNA degradation can be initiated…”
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Targeting the nuclear RNA exosome: Poly(A) binding proteins enter the stage by Meola, Nicola, Jensen, Torben Heick

“…Centrally positioned in nuclear RNA metabolism, the exosome deals with virtually all transcript types. This 3′-5′ exo- and endo-nucleolytic degradation machine…”
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Structure and regulation of the nuclear exosome targeting complex guides RNA substrates to the exosome by Gerlach, Piotr, Garland, William, Lingaraju, Mahesh, Salerno-Kochan, Anna, Bonneau, Fabien, Basquin, Jérôme, Jensen, Torben Heick, Conti, Elena

“…In mammalian cells, spurious transcription results in a vast repertoire of unproductive non-coding RNAs, whose deleterious accumulation is prevented by rapid…”
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Rapid factor depletion highlights intricacies of nucleoplasmic RNA degradation by Gockert, Maria, Schmid, Manfred, Jakobsen, Lis, Jens, Marvin, Andersen, Jens S, Jensen, Torben Heick

“…Abstract Turnover of nucleoplasmic transcripts by the mammalian multi-subunit RNA exosome is mediated by two adaptors: the Nuclear EXosome Targeting (NEXT)…”
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