Search Results - "Jensen, Taylor J."

Role for DNA methylation in the regulation of miR-200c and miR-141 expression in normal and cancer cells by Vrba, Lukas, Jensen, Taylor J, Garbe, James C, Heimark, Ronald L, Cress, Anne E, Dickinson, Sally, Stampfer, Martha R, Futscher, Bernard W

“…The microRNA-200 family participates in the maintenance of an epithelial phenotype and loss of its expression can result in epithelial to mesenchymal…”
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Determination of fetal DNA fraction from the plasma of pregnant women using sequence read counts by Kim, Sung K., Hannum, Gregory, Geis, Jennifer, Tynan, John, Hogg, Grant, Zhao, Chen, Jensen, Taylor J., Mazloom, Amin R., Oeth, Paul, Ehrich, Mathias, van den Boom, Dirk, Deciu, Cosmin

“…Objective This study introduces a novel method, referred to as SeqFF, for estimating the fetal DNA fraction in the plasma of pregnant women and to infer the…”
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Incidental Detection of Maternal Neoplasia in Noninvasive Prenatal Testing by Dharajiya, Nilesh G, Grosu, Daniel S, Farkas, Daniel H, McCullough, Ron M, Almasri, Eyad, Sun, Youting, Kim, Sung K, Jensen, Taylor J, Saldivar, Juan-Sebastian, Topol, Eric J, van den Boom, Dirk, Ehrich, Mathias

“…Noninvasive prenatal testing (NIPT) uses cell-free DNA (cfDNA) as an analyte to detect copy-number alterations in the fetal genome. Because maternal and fetal…”
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Detection of Microdeletion 22q11.2 in a Fetus by Next-Generation Sequencing of Maternal Plasma by JENSEN, Taylor J, DZAKULA, Zeljko, DECIU, Cosmin, VAN DEN BOOM, Dirk, EHRICH, Mathias

“…Efforts have been undertaken recently to assess the fetal genome through analysis of circulating cell-free (ccf) fetal DNA obtained from maternal plasma…”
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High-throughput massively parallel sequencing for fetal aneuploidy detection from maternal plasma by Jensen, Taylor J, Zwiefelhofer, Tricia, Tim, Roger C, Džakula, Željko, Kim, Sung K, Mazloom, Amin R, Zhu, Zhanyang, Tynan, John, Lu, Tim, McLennan, Graham, Palomaki, Glenn E, Canick, Jacob A, Oeth, Paul, Deciu, Cosmin, van den Boom, Dirk, Ehrich, Mathias

“…Circulating cell-free (ccf) fetal DNA comprises 3-20% of all the cell-free DNA present in maternal plasma. Numerous research and clinical studies have…”
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Quantification of Fetal DNA by Use of Methylation-Based DNA Discrimination by NYGREN, Anders O. H, DEAN, Jarrod, JENSEN, Taylor J, KRUSE, Selena, KWONG, William, VAN DEN BOOM, Dirk, EHRICH, Mathias

“…Detection of circulating cell-free fetal nucleic acids in maternal plasma has been used in noninvasive prenatal diagnostics. Most applications rely on the…”
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Mechanisms of immune modulation in the tumor microenvironment and implications for targeted therapy by Czajka-Francuz, Paulina, Prendes, Maria J, Mankan, Arun, Quintana, Ángela, Pabla, Sarabjot, Ramkissoon, Shakti, Jensen, Taylor J, Peiró, Sandra, Severson, Eric A, Achyut, Bhagelu R, Vidal, Laura, Poelman, Martine, Saini, Kamal S

“…The efficacy of cancer therapies is limited to a great extent by immunosuppressive mechanisms within the tumor microenvironment (TME). Numerous immune escape…”
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Cancer testis antigen burden (CTAB): a novel biomarker of tumor-associated antigens in lung cancer by Seager, R J, Senosain, Maria-Fernanda, Van Roey, Erik, Gao, Shuang, DePietro, Paul, Nesline, Mary K, Dash, Durga Prasad, Zhang, Shengle, Ko, Heidi, Hastings, Stephanie B, Strickland, Kyle C, Previs, Rebecca A, Jensen, Taylor J, Eisenberg, Marcia, Caveney, Brian J, Severson, Eric A, Ramkissoon, Shakti, Conroy, Jeffrey M, Pabla, Sarabjot

“…Cancer-testis antigens (CTAs) are tumor antigens that are normally expressed in the testes but are aberrantly expressed in several cancers. CTA overexpression…”
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Real-world comprehensive genomic and immune profiling reveals distinct age- and sex-based genomic and immune landscapes in tumors of patients with non-small cell lung cancer by Wallen, Zachary D, Ko, Heidi, Nesline, Mary K, Hastings, Stephanie B, Strickland, Kyle C, Previs, Rebecca A, Zhang, Shengle, Pabla, Sarabjot, Conroy, Jeffrey, Jackson, Jennifer B, Saini, Kamal S, Jensen, Taylor J, Eisenberg, Marcia, Caveney, Brian, Sathyan, Pratheesh, Severson, Eric A, Ramkissoon, Shakti H

“…Younger patients with non-small cell lung cancer (NSCLC) (<50 years) represent a significant patient population with distinct clinicopathological features and…”
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Case report: Single gene testing and comprehensive genomic profiling in non-small cell lung cancer—a case series of divergent results from a large reference laboratory by Strickland, Kyle C., Nesline, Mary K., Previs, Rebecca A., Ko, Heidi, Cooper, Maureen, Rushton, Jennifer R., Wallen, Zachary D., Pabla, Sarabjot, Conroy, Jeffrey M., Sausen, Mark, Saini, Kamal S., Cantini, Luca, Jensen, Taylor J., Caveney, Brian J., Eisenberg, Marcia, Severson, Eric A., Ramkissoon, Shakti

“…Clinical management of non-small cell lung cancer (NSCLC) requires accurate identification of tumor-specific genetic alterations to inform treatment options…”
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Genetic and epigenetic inactivation of extracellular superoxide dismutase promotes an invasive phenotype in human lung cancer by disrupting ECM homeostasis by Teoh-Fitzgerald, Melissa L T, Fitzgerald, Matthew P, Jensen, Taylor J, Futscher, Bernard W, Domann, Frederick E

“…Extracellular superoxide dismutase (EcSOD) is an important superoxide scavenger in the lung in which its loss, sequence variation, or abnormal expression…”
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Cell-type specific DNA methylation patterns define human breast cellular identity by Novak, Petr, Stampfer, Martha R, Munoz-Rodriguez, Jose L, Garbe, James C, Ehrich, Mathias, Futscher, Bernard W, Jensen, Taylor J

“…DNA methylation plays a role in a variety of biological processes including embryonic development, imprinting, X-chromosome inactivation, and stem cell…”
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Horizons in Veterinary Precision Oncology: Fundamentals of Cancer Genomics and Applications of Liquid Biopsy for the Detection, Characterization, and Management of Cancer in Dogs by Chibuk, Jason, Flory, Andi, Kruglyak, Kristina M, Leibman, Nicole, Nahama, Alexis, Dharajiya, Nilesh, van den Boom, Dirk, Jensen, Taylor J, Friedman, Jeffrey S, Shen, M Richard, Clemente-Vicario, Francisco, Chorny, Ilya, Tynan, John A, Lytle, Katherine M, Holtvoigt, Lauren E, Murtaza, Muhammed, Diaz, Jr, Luis A, Tsui, Dana W Y, Grosu, Daniel S

“…Cancer is the leading cause of death in dogs, in part because many cases are identified at an advanced stage when clinical signs have developed, and prognosis…”
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Epigenetic mediated transcriptional activation of WNT5A participates in arsenical-associated malignant transformation by Jensen, Taylor J., Wozniak, Ryan J., Eblin, Kylee E., Wnek, Sean M., Gandolfi, A. Jay, Futscher, Bernard W.

“…Arsenic is a human carcinogen with exposure associated with cancer of the lung, skin, and bladder. Many potential mechanisms have been implicated as playing a…”
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Genome-wide sequencing of cell-free DNA identifies copy number alterations that can be used for monitoring response to immunotherapy in cancer patients by Jensen, Taylor J, Goodman, Aaron M, Kato, Shumei, Ellison, Christopher K, Daniels, Gregory A, Kim, Lisa, Nakashe, Prachi, McCarthy, Erin, Mazloom, Amin R, McLennan, Graham, Grosu, Daniel S, Ehrich, Mathias, Kurzrock, Razelle

“…Inhibitors of the PD-1/PD-L1/CTLA4 immune checkpoint pathway have revolutionized cancer treatment. Indeed, some patients with advanced, refractory malignancies…”
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Whole genome bisulfite sequencing of cell-free DNA and its cellular contributors uncovers placenta hypomethylated domains by Jensen, Taylor J, Kim, Sung K, Zhu, Zhanyang, Chin, Christine, Gebhard, Claudia, Lu, Tim, Deciu, Cosmin, van den Boom, Dirk, Ehrich, Mathias

“…Circulating cell-free fetal DNA has enabled non-invasive prenatal fetal aneuploidy testing without direct discrimination of the maternal and fetal DNA. Testing…”
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Metastatic basal cell carcinoma with amplification of PD-L1: exceptional response to anti-PD1 therapy by Ikeda, Sadakatsu, Goodman, Aaron M, Cohen, Philip R, Jensen, Taylor J, Ellison, Christopher K, Frampton, Garrett, Miller, Vincent, Patel, Sandip P, Kurzrock, Razelle

“…Metastatic basal cell carcinomas are rare malignancies harbouring Hedgehog pathway alterations targetable by SMO antagonists (vismodegib/sonidegib). We…”
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RNA Sequencing Identifies Novel NRG1 Fusions in Solid Tumors that Lack Co-Occurring Oncogenic Drivers by Severson, Eric, Achyut, Bhagelu R., Nesline, Mary, Pabla, Sarabjot, Previs, Rebecca A., Kannan, Geoffrey, Chenn, Anjen, Zhang, Shengle, Klein, Roger, Conroy, Jeffrey, Sausen, Mark, Sathyan, Pratheesh, Saini, Kamal S., Ghosh, Aradhana, Jensen, Taylor J., Reddy, Prasanth, Ramkissoon, Shakti H.

“…NRG1 gene fusions are rare, therapeutically relevant, oncogenic drivers that occur across solid tumor types. To understand the landscape of NRG1 gene fusions,…”
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Stepwise DNA Methylation Changes Are Linked to Escape from Defined Proliferation Barriers and Mammary Epithelial Cell Immortalization by NOVAK, Petr, JENSEN, Taylor J, GARBE, James C, STAMPFER, Martha R, FUTSCHER, Bernard W

“…The timing and progression of DNA methylation changes during carcinogenesis are not completely understood. To develop a timeline of aberrant DNA methylation…”
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A consensus-based classification workflow to determine genetically inferred ancestry from comprehensive genomic profiling of patients with solid tumors by Wallen, Zachary D, Nesline, Mary K, Pabla, Sarabjot, Gao, Shuang, Vanroey, Erik, Hastings, Stephanie B, Ko, Heidi, Strickland, Kyle C, Previs, Rebecca A, Zhang, Shengle, Conroy, Jeffrey M, Jensen, Taylor J, George, Elizabeth, Eisenberg, Marcia, Caveney, Brian, Sathyan, Pratheesh, Ramkissoon, Shakti, Severson, Eric A

“…Abstract Disparities in cancer diagnosis, treatment, and outcomes based on self-identified race and ethnicity (SIRE) are well documented, yet these variables…”
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