Search Results - "Jensen, R Paul"

Natural Products and the Gene Cluster Revolution by Jensen, Paul R

“…Genome sequencing has created unprecedented opportunities for natural-product discovery and new insight into the diversity and distributions of natural-product…”
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Developing a new resource for drug discovery: marine actinomycete bacteria by Fenical, William, Jensen, Paul R

“…Interest in natural-product drug discovery has waned, in part owing to diminishing returns from traditional resources such as soil bacteria. Yet like many…”
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The natural product domain seeker NaPDoS: a phylogeny based bioinformatic tool to classify secondary metabolite gene diversity by Ziemert, Nadine, Podell, Sheila, Penn, Kevin, Badger, Jonathan H, Allen, Eric, Jensen, Paul R

“…New bioinformatic tools are needed to analyze the growing volume of DNA sequence data. This is especially true in the case of secondary metabolite…”
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The marine actinomycete genus Salinispora: a model organism for secondary metabolite discovery by Jensen, Paul R, Moore, Bradley S, Fenical, William

“…This review covers the initial discovery of the marine actinomycete genus Salinispora through its development as a model for natural product research. A focus…”
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Omics-based natural product discovery and the lexicon of genome mining by Machado, Henrique, Tuttle, Robert N, Jensen, Paul R

“…•A lexicon for biosynthetic gene clusters and the small molecules they encode.•Omic approaches advance natural product discovery.•Knowledge gaps in the…”
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Identification of Thiotetronic Acid Antibiotic Biosynthetic Pathways by Target-directed Genome Mining by Tang, Xiaoyu, Li, Jie, Millán-Aguiñaga, Natalie, Zhang, Jia Jia, O’Neill, Ellis C, Ugalde, Juan A, Jensen, Paul R, Mantovani, Simone M, Moore, Bradley S

“…Recent genome sequencing efforts have led to the rapid accumulation of uncharacterized or “orphaned” secondary metabolic biosynthesis gene clusters (BGCs) in…”
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Comparative transcriptomics as a guide to natural product discovery and biosynthetic gene cluster functionality by Amos, Gregory C. A., Awakawa, Takayoshi, Tuttle, Robert N., Letzel, Anne-Catrin, Kim, Min Cheol, Kudo, Yuta, Fenical, William, Moore, Bradley S., Jensen, Paul R.

“…Bacterial natural products remain an important source of new medicines. DNA sequencing has revealed that a majority of natural product biosynthetic gene…”
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Metagenomic discovery of polybrominated diphenyl ether biosynthesis by marine sponges by Agarwal, Vinayak, Blanton, Jessica M, Podell, Sheila, Taton, Arnaud, Schorn, Michelle A, Busch, Julia, Lin, Zhenjian, Schmidt, Eric W, Jensen, Paul R, Paul, Valerie J, Biggs, Jason S, Golden, James W, Allen, Eric E, Moore, Bradley S

“…Metagenomic analysis and functional characterization of biosynthetic genes uncovers the basis for widespread polybrominated diphenyl ether biosynthesis in…”
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The Marinopyrroles, Antibiotics of an Unprecedented Structure Class from a Marine Streptomyces sp by Hughes, Chambers C, Prieto-Davo, Alejandra, Jensen, Paul R, Fenical, William

“…Cultivation of an obligate marine Streptomyces strain has furnished the marinopyrroles A and B, densely halogenated, axially chiral metabolites that contain an…”
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Phylogenetic Diversity of Gram-Positive Bacteria Cultured from Marine Sediments by Gontang, Erin A, Fenical, William, Jensen, Paul R

“…Major advances in our understanding of marine bacterial diversity have been gained through studies of bacterioplankton, the vast majority of which appear to be…”
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Prioritizing Natural Product Diversity in a Collection of 146 Bacterial Strains Based on Growth and Extraction Protocols by Crüsemann, Max, O’Neill, Ellis C, Larson, Charles B, Melnik, Alexey V, Floros, Dimitrios J, da Silva, Ricardo R, Jensen, Paul R, Dorrestein, Pieter C, Moore, Bradley S

“…In order to expedite the rapid and efficient discovery and isolation of novel specialized metabolites, while minimizing the waste of resources on rediscovery…”
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Function-related replacement of bacterial siderophore pathways by Bruns, Hilke, Crüsemann, Max, Letzel, Anne-Catrin, Alanjary, Mohammad, McInerney, James O, Jensen, Paul R, Schulz, Stefan, Moore, Bradley S, Ziemert, Nadine

“…Bacterial genomes are rife with orphan biosynthetic gene clusters (BGCs) associated with secondary metabolism of unrealized natural product molecules. Often up…”
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Comparative genomics reveals evidence of marine adaptation in Salinispora species by Penn, Kevin, Jensen, Paul R

“…Actinobacteria represent a consistent component of most marine bacterial communities yet little is known about the mechanisms by which these Gram-positive…”
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Species-Specific Secondary Metabolite Production in Marine Actinomycetes of the Genus Salinispora by Jensen, Paul R, Williams, Philip G, Oh, Dong-Chan, Zeigler, Lisa, Fenical, William

“…Here we report associations between secondary metabolite production and phylogenetically distinct but closely related marine actinomycete species belonging to…”
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Vertical Inheritance Facilitates Interspecies Diversification in Biosynthetic Gene Clusters and Specialized Metabolites by Chase, Alexander B, Sweeney, Douglas, Muskat, Mitchell N, Guillén-Matus, Dulce G, Jensen, Paul R

“…While specialized metabolites are thought to mediate ecological interactions, the evolutionary processes driving chemical diversification, particularly among…”
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Hidden formaldehyde in e-cigarette aerosols by Jensen, R Paul, Luo, Wentai, Pankow, James F, Strongin, Robert M, Peyton, David H

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Chlorizidine, a Cytotoxic 5H‑Pyrrolo[2,1‑a]isoindol-5-one-Containing Alkaloid from a Marine Streptomyces sp by Alvarez-Mico, Xavier, Jensen, Paul R, Fenical, William, Hughes, Chambers C

“…Cultivation of an obligate marine Streptomyces strain has provided the cytotoxic natural product chlorizidine A. X-ray crystallographic analysis revealed that…”
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Genome sequencing reveals complex secondary metabolome in the marine actinomycete Salinispora tropica by Udwary, Daniel W, Zeigler, Lisa, Asolkar, Ratnakar N, Singan, Vasanth, Lapidus, Alla, Fenical, William, Jensen, Paul R, Moore, Bradley S

“…Recent fermentation studies have identified actinomycetes of the marine-dwelling genus Salinispora as prolific natural product producers. To further evaluate…”
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Discovery and development of the anticancer agent salinosporamide A (NPI-0052) by Fenical, William, Jensen, Paul R., Palladino, Michael A., Lam, Kin S., Lloyd, G. Kenneth, Potts, Barbara C.

“…The discovery of the anticancer agent salinosporamide A (NPI-0052) resulted from the exploration of new marine environments and a commitment to the potential…”
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Small molecule in situ resin capture provides a compound first approach to natural product discovery by Bogdanov, Alexander, Salib, Mariam N., Chase, Alexander B., Hammerlindl, Heinz, Muskat, Mitchell N., Luedtke, Stephanie, da Silva, Elany Barbosa, O’Donoghue, Anthony J., Wu, Lani F., Altschuler, Steven J., Molinski, Tadeusz F., Jensen, Paul R.

“…Culture-based microbial natural product discovery strategies fail to realize the extraordinary biosynthetic potential detected across earth’s microbiomes. Here…”
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