Search Results - "Jensen, Pernille R"

Production of hyperpolarized [1,4-¹³C₂]malate from [1,4-¹³C₂]fumarate is a marker of cell necrosis and treatment response in tumors by Gallagher, Ferdia A, Kettunen, Mikko I, Hu, De-En, Jensen, Pernille R, Zandt, René in 't, Karlsson, Magnus, Gisselsson, Anna, Nelson, Sarah K, Witney, Timothy H, Bohndiek, Sarah E, Hansson, Georg, Peitersen, Torben, Lerche, Mathilde H, Brindle, Kevin M

“…Dynamic nuclear polarization of ¹³C-labeled cell substrates has been shown to massively increase their sensitivity to detection in NMR experiments. The…”
Get full text

Hyperpolarized NMR probes for biological assays by Meier, Sebastian, Jensen, Pernille R, Karlsson, Magnus, Lerche, Mathilde H

“…During the last decade, the development of nuclear spin polarization enhanced (hyperpolarized) molecular probes has opened up new opportunities for studying…”
Get full text

Metabolic pathway visualization in living yeast by DNP-NMR by Meier, Sebastian, Karlsson, Magnus, Jensen, Pernille R, Lerche, Mathilde H, Duus, Jens Ø

“…Central carbon metabolism of living Saccharomyces cerevisiae is visualized by DNP-NMR. Experiments are conducted as real time assays that detect metabolic…”
Get more information

Hyperpolarized [1,3‐13C2]ethyl acetoacetate is a novel diagnostic metabolic marker of liver cancer by Jensen, Pernille R., Serra, Sonia Colombo, Miragoli, Luigi, Karlsson, Magnus, Cabella, Claudia, Poggi, Luisa, Venturi, Luca, Tedoldi, Fabio, Lerche, Mathilde H.

“…An increased prevalence of liver diseases such as hepatitis C and nonalcoholic fatty liver results in an augmented incidence of the most common form of liver…”
Get full text

Tissue-specific Short Chain Fatty Acid Metabolism and Slow Metabolic Recovery after Ischemia from Hyperpolarized NMR in Vivo by Jensen, Pernille R., Peitersen, Torben, Karlsson, Magnus, in 't Zandt, René, Gisselsson, Anna, Hansson, Georg, Meier, Sebastian, Lerche, Mathilde H.

“…Mechanistic details of mammalian metabolism in vivo and dynamic metabolic changes in intact organisms are difficult to monitor because of the lack of spatial,…”
Get full text

Direct Observation of Metabolic Differences in Living Escherichia Coli Strains K-12 and BL21 by Meier, Sebastian, Jensen, Pernille R., Duus, Jens Ø.

“…Direct observation of metabolism on a timescale of seconds shows altered usage, due to genomic differences, of one specific reaction in living E. coli K‐12 and…”
Get full text

Hyperpolarized Amino Acids for In Vivo Assays of Transaminase Activity by Jensen, Pernille R., Karlsson, Magnus, Meier, Sebastian, Duus, Jens Ø., Lerche, Mathilde H.

“…Novel markers: NMR spectroscopy has a unique potential to monitor chemical reactions in vivo (see figure). Unlike other imaging techniques, non‐invasive NMR…”
Get full text

Development of Dissolution DNP-MR Substrates for Metabolic Research by Karlsson, Magnus, Jensen, Pernille R., Duus, Jens Ø., Meier, Sebastian, Lerche, Mathilde H.

“…Dissolution dynamic nuclear polarization (DNP) provides a broadly applicable and rather simple means of developing probes for the real-time molecular imaging…”
Get full text

Continuous Molecular Evolution of Protein-Domain Structures by Single Amino Acid Changes by Meier, Sebastian, Jensen, Pernille R., David, Charles N., Chapman, Jarrod, Holstein, Thomas W., Grzesiek, Stephan, Özbek, Suat

“…Protein structures cluster into families of folds that can result from extremely different amino acid sequences [1]. Because the enormous amount of genetic…”
Get full text

NMR Insights into the Inner Workings of Living Cells by Lerche, Mathilde H, Jensen, Pernille R, Karlsson, Magnus, Meier, Sebastian

Get full text

Magnetic resonance imaging of pH in vivo using hyperpolarized [sup.13]C-labelled bicarbonate by Gallagher, Ferdia A, Kettunen, Mikko I, Day, Sam E, Hu, De-En, Ardenkjaer-Larsen, Jan Henrik, Zandt, Rene in't, Jensen, Pernille R, Karlsson, Magnus, Golman, Klaes, Lerche, Mathilde H, Brindle, Kevin M

Get full text

Combined In-Cell NMR and Simulation Approach to Probe Redox-Dependent Pathway Control by Jensen, Pernille R, Matos, Marta R. A, Sonnenschein, Nikolaus, Meier, Sebastian

“…Dynamic response of intracellular reaction cascades to changing environments is a hallmark of living systems. As metabolism is complex, mechanistic models have…”
Get full text

Stable Isotope-Resolved Analysis with Quantitative Dissolution Dynamic Nuclear Polarization by Lerche, Mathilde H, Yigit, Demet, Frahm, Anne B, Ardenkjær-Larsen, Jan Henrik, Malinowski, Ronja M, Jensen, Pernille R

“…Metabolite profiles and their isotopomer distributions can be studied noninvasively in complex mixtures with NMR. The advent of dissolution Dynamic Nuclear…”
Get full text

Real-time detection of central carbon metabolism in living Escherichia coli and its response to perturbations by Meier, Sebastian, Jensen, Pernille R., Duus, Jens Ø.

“…► Metabolic networks are visualized in living Escherichia coli with pulse-response experiments. ► Adaptations of central carbon metabolism are directly made…”
Get full text

Visualization of Pathway Usage in an Extended Carbohydrate Conversion Network Reveals the Impact of Solvent-Enabled Proton Transfer by Jensen, Pernille R, Knudsen, Rikke K, Meier, Sebastian

“…Bio-sourced molecules should increasingly contribute to meeting societal demands for energy and chemicals, while reducing net carbon dioxide release and the…”
Get full text

Pancreatic β-cells respond to fuel pressure with an early metabolic switch by Malinowski, Ronja M., Ghiasi, Seyed M., Mandrup-Poulsen, Thomas, Meier, Sebastian, Lerche, Mathilde H., Ardenkjær-Larsen, Jan H., Jensen, Pernille R.

“…Pancreatic β-cells become irreversibly damaged by long-term exposure to excessive glucose concentrations and lose their ability to carry out glucose stimulated…”
Get full text

Real-Time DNP NMR Observations of Acetic Acid Uptake, Intracellular Acidification, and of Consequences for Glycolysis and Alcoholic Fermentation in Yeast by Jensen, Pernille R., Karlsson, Magnus, Lerche, Mathilde H., Meier, Sebastian

“…Uptake and upshot in vivo: Straightforward methods that permit the real‐time observation of organic acid influx, intracellular acidification, and concomitant…”
Get full text

Targeted Metabolomics with Quantitative Dissolution Dynamic Nuclear Polarization by Lerche, Mathilde H, Karlsson, Magnus, Ardenkjær-Larsen, Jan H, Jensen, Pernille R

“…Metabolite profiles and their isotopomer distributions can be studied noninvasively in complex mixtures with NMR. The advent of hyperpolarized C-NMR using…”
Get more information

WhiB7, an Fe-S-dependent Transcription Factor That Activates Species-specific Repertoires of Drug Resistance Determinants in Actinobacteria by Ramón-García, Santiago, Ng, Carol, Jensen, Pernille R., Dosanjh, Manisha, Burian, Jan, Morris, Rowan P., Folcher, Marc, Eltis, Lindsay D., Grzesiek, Stephan, Nguyen, Liem, Thompson, Charles J.

“…WhiB-like (Wbl) proteins are well known for their diverse roles in actinobacterial morphogenesis, cell division, virulence, primary and secondary metabolism,…”
Get full text

Inhibition of beta cell growth and function by bone morphogenetic proteins by Bruun, Christine, Christensen, Gitte L., Jacobsen, Marie L. B., Kanstrup, Marianne B., Jensen, Pernille R., Fjordvang, Helle, Mandrup-Poulsen, Thomas, Billestrup, Nils

“…Aims/hypothesis Impairment of beta cell mass and function is evident in both type 1 and type 2 diabetes. In healthy physiological conditions pancreatic beta…”
Get full text