Search Results - "Jensen, Mark S."

An Improved Protocol for the Preparation of 3-Pyridyl- and Some Arylboronic Acids by Li, Wenjie, Nelson, Dorian P, Jensen, Mark S, Hoerrner, R. Scott, Cai, Dongwei, Larsen, Robert D, Reider, Paul J

“…3-Pyridylboronic acid was prepared in high yield and bulk quantity from 3-bromopyridine via a protocol of lithium−halogen exchange and “in situ quench”. This…”
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Efficient Synthesis of a GABAA α2,3-Selective Allosteric Modulator via a Sequential Pd-Catalyzed Cross-Coupling Approach by Jensen, Mark S, Hoerrner, R. Scott, Li, Wenjie, Nelson, Dorian P, Javadi, Gary J, Dormer, Peter G, Cai, Dongwei, Larsen, Robert D

“…A practical synthesis of 2-[3-(4-fluoro-3-pyridin-3-yl-phenyl)-imidazo[1,2-a]pyrimidin-7-yl]-propan-2-ol (1), an oral GABAA α2/3-selective agonist, is…”
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Synthesis of an Anti-Methicillin-Resistant Staphylococcus aureus (MRSA) Carbapenem via Stannatrane-Mediated Stille Coupling by Jensen, Mark S, Yang, Chunhua, Hsiao, Yi, Rivera, Nelo, Wells, Kenneth M, Chung, John Y. L, Yasuda, Nobuyoshi, Hughes, David L, Reider, Paul J

“…A short synthesis of carbapenem 1 is described. The key step involves the cross-coupling of an enol triflate with an amino-substituted sp3 carbon. This…”
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Cyclopropane-Containing Eicosanoids of Marine Origin. Biomimetic Synthesis of Constanolactones A and B from the Alga Constantinea simplex by White, James D, Jensen, Mark S

“…Asymmetric syntheses of a substance isolated from incubation of arachidonic acid with an acetone powder of the coral Plexaura homomalla, and of…”
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Palladium-Catalyzed Regioselective Arylation of Imidazo[1,2-a]pyrimidine by Li, Wenjie, Nelson, Dorian P, Jensen, Mark S, Hoerrner, R. Scott, Javadi, Gary J, Cai, Dongwei, Larsen, Robert D

“…Imidazo[1,2-a]pyrimidine can be arylated at the 3-position with aryl bromides in the presence of base and a catalytic amount of palladium. This provides an…”
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An Efficient Synthesis of an αvβ3 Antagonist by Yasuda, Nobuyoshi, Hsiao, Yi, Jensen, Mark S, Rivera, Nelo R, Yang, Chunhua, Wells, Kenneth M, Yau, James, Palucki, Michael, Tan, Lushi, Dormer, Peter G, Volante, Ralph P, Hughes, David L, Reider, Paul J

“…A practical preparation of an αvβ3 antagonist is reported. The antagonist consists of three key components, a tetrahydronaphthyridine moiety, a β-alanine…”
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Mild and Practical Method for the α-Arylation of Nitriles with Heteroaryl Halides by Klapars, Artis, Waldman, Jacob H, Campos, Kevin R, Jensen, Mark S, McLaughlin, Mark, Chung, John Y. L, Cvetovich, Raymond J, Chen, Cheng-yi

“…A mild and transition-metal-free method for the α-arylation of aliphatic nitriles with activated heteroaryl halides was developed using NaHMDS or KHMDS as base…”
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Biomimetic synthesis of a cyclopropane containing eicosanoid from the coral Plexaura homomalla. Assignment of relative configuration by White, James D, Jensen, Mark S

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Stereoselective synthesis of an anti-HIV drug candidate by Conlon, David A., Jensen, Mark S., Palucki, Michael, Yasuda, Nobuyoshi, Um, Joann M., Yang, Chunhua, Hartner, Frederick W., Tsay, Fuh-Rong, Hsiao, Yi, Pye, Philip, Rivera, Nelo R., Hughes, David L.

“…The asymmetric synthesis of a Merck anti‐HIV drug candidate is described. The target molecule contains four stereogenic centers, three of which are located in…”
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A Strategy for Total Synthesis of Complex Cardenolides by Deng, Wei, Jensen, Mark S, Overman, Larry E, Rucker, Paul V, Vionnet, Jean-Paul

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Preparation of crystallinep-nitrobenzyl 2-hydroxymethyl carbapenem as a key intermediate for the anti-MRS carbapenem L-786,392 by Yasuda, Nobuyoshi, Yang, Chunhua, Wells, Kenneth M., Jensen, Mark S., Hughes, David L.

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An approximate formula for the intermolecular Pauli repulsion between closed shell molecules by JAN H JENSEN MARK S GORDON

“…The exchange repulsion formula proposed by Murrell and co-workers (Proc. Roy. Soc. (Lond.) 1965, A284, 566; J. chem. Phys., 1967, 47, 4916) is considered in…”
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Efficient synthesis of a GABA A alpha2,3-selective allosteric modulator via a sequential Pd-catalyzed cross-coupling approach by Jensen, Mark S, Hoerrner, R Scott, Li, Wenjie, Nelson, Dorian P, Javadi, Gary J, Dormer, Peter G, Cai, Dongwei, Larsen, Robert D

“…A practical synthesis of 2-[3-(4-fluoro-3-pyridin-3-yl-phenyl)-imidazo[1,2-a]pyrimidin-7-yl]-propan-2-ol (1), an oral GABA(A) alpha(2/3)-selective agonist, is…”
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Efficient Synthesis of a GABA A α 2,3 -Selective Allosteric Modulator via a Sequential Pd-Catalyzed Cross-Coupling Approach by Jensen, Mark S., Hoerrner, R. Scott, Li, Wenjie, Nelson, Dorian P., Javadi, Gary J., Dormer, Peter G., Cai, Dongwei, Larsen, Robert D.

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Synthesis of 1,3-dienes of ( E, Z) configuration by a three-component coupling strategy by White, James D., Jensen, Mark S.

“…Three-component coupling of an anionic nucleophile, butadienyltriphenylphosphonium bromide, and an aldehyde gave conjugated dienes of predominantly ( E, Z)…”
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An efficient synthesis of an alphavbeta3 antagonist by Yasuda, Nobuyoshi, Hsiao, Yi, Jensen, Mark S, Rivera, Nelo R, Yang, Chunhua, Wells, Kenneth M, Yau, James, Palucki, Michael, Tan, Lushi, Dormer, Peter G, Volante, Ralph P, Hughes, David L, Reider, Paul J

“…A practical preparation of an alpha(v)beta(3) antagonist is reported. The antagonist consists of three key components, a tetrahydronaphthyridine moiety, a…”
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An Efficient Synthesis of an α v β 3 Antagonist by Yasuda, Nobuyoshi, Hsiao, Yi, Jensen, Mark S., Rivera, Nelo R., Yang, Chunhua, Wells, Kenneth M., Yau, James, Palucki, Michael, Tan, Lushi, Dormer, Peter G., Volante, Ralph P., Hughes, David L., Reider, Paul J.

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Preparation of crystalline p-nitrobenzyl 2-hydroxymethyl carbapenem as a key intermediate for the anti-MRS carbapenem L-786,392 by Yasuda, Nobuyoshi, Yang, Chunhua, Wells, Kenneth M., Jensen, Mark S., Hughes, David L.

“…Crystalline p-nitrobenzyl esters of 2-hydroxymethyl carbapenem derivatives were prepared in one pot from the corresponding diazo compounds and Bu 3SnCH 2OH…”
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A simple and scalable method to prepare 1-aza-5-chloro-5-stannabicyclo[3.3.3]undecane by Yang, Chunhua, Jensen, Mark S, Conlon, David A, Yasuda, Nobuyoshi, Hughes, David L

“…A simple and scalable method for the preparation of a potentially versatile organostannane, 1-aza-5-chloro-5-stannabicyclo[3.3.3]undecane ( 1), is described…”
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Preparation of crystalline p-nitrobenzyl 2-formyl carbapenems by oxidative cleavage by Hsiao, Yi, Wells, Kenneth M., Yang, Chunhua, Jensen, Mark S., Chung, John Y.L., Yasuda, Nobuyoshi, Hughes, David L.

“…Crystalline 1β-methyl-2-formyl carbapenem pNB esters were prepared by osmium-mediated oxidative cleavage of the corresponding 2-vinyl derivatives. Reduction of…”
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