Search Results - "Jensen, Klaus Gjervig"

Discovery of 1-[2-(2,4-Dimethylphenylsulfanyl)phenyl]piperazine (Lu AA21004): A Novel Multimodal Compound for the Treatment of Major Depressive Disorder by Bang-Andersen, Benny, Ruhland, Thomas, Jørgensen, Morten, Smith, Garrick, Frederiksen, Kristen, Jensen, Klaus Gjervig, Zhong, Huailing, Nielsen, Søren Møller, Hogg, Sandra, Mørk, Arne, Stensbøl, Tine Bryan

“…The synthesis and structure−activity relationship of a novel series of compounds with combined effects on 5-HT3A and 5-HT1A receptors and on the serotonin…”
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Distal kinetic deuterium isotope effect: Phenyl ring deuteration attenuates N-demethylation of Lu AF35700 by Gjervig Jensen, Klaus, Tornby Christoffersen, Claus, Graulund Hvenegaard, Mette, Didriksen, Michael, Jørgensen, Morten

“…[Display omitted] The N-demethylation of zicronapine (7) and three of its deuterated analogs 8 – 10 has been studied in human in vitro metabolism systems…”
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Test systems in drug discovery for hazard identification and risk assessment of human drug-induced liver injury by Weaver, Richard J, Betts, Catherine, Blomme, Eric A G, Gerets, Helga H J, Gjervig Jensen, Klaus, Hewitt, Philip G, Juhila, Satu, Labbe, Gilles, Liguori, Michael J, Mesens, Natalie, Ogese, Monday O, Persson, Mikael, Snoeys, Jan, Stevens, James L, Walker, Tracy, Park, B Kevin

“…The liver is an important target for drug-induced toxicities. Early detection of hepatotoxic drugs requires use of well-characterized test systems, yet current…”
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Risk assessment of accidental nortriptyline poisoning: The importance of cytochrome P450 for nortriptyline elimination investigated using a population-based pharmacokinetic simulator by Jornil, Jakob, Jensen, Klaus Gjervig, Larsen, Frank, Linnet, Kristian

“…It is not possible to make a prospective clinical study that reveals the importance of the nortriptyline metabolising cytochrome P450 (CYP) isoforms (CYP1A2,…”
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5-Hydroxy- l-tryptophan alters gaboxadol pharmacokinetics in rats: Involvement of PAT1 and rOat1 in gaboxadol absorption and elimination by Larsen, Mie, Holm, René, Jensen, Klaus Gjervig, Sveigaard, Christina, Brodin, Birger, Nielsen, Carsten Uhd

“…The aim was to investigate the effect of 5-hydroxy- l-tryptophan (5-HTP) on gaboxadol pharmacokinetics in rats. As both 5-HTP and gaboxadol bind to the human…”
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Hit-to-lead investigation of a series of novel combined dopamine D2 and muscarinic M1 receptor ligands with putative antipsychotic and pro-cognitive potential by Sams, Anette Graven, Larsen, Krestian, Mikkelsen, Gitte Kobberøe, Hentzer, Morten, Christoffersen, Claus Tornby, Jensen, Klaus Gjervig, Frederiksen, Kristen, Bang-Andersen, Benny

“…We describe the discovery of a series of compounds based on…”
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New α1-adrenoceptor antagonists derived from the antipsychotic sertindole - carbon-11 labelling and pet examination of brain uptake in the cynomolgus monkey by Balle, Thomas, Halldin, Christer, Andersen, Linus, Hjorth Alifrangis, Lene, Badolo, Lassina, Gjervig Jensen, Klaus, Chou, Yuan-Wha, Andersen, Kim, Perregaard, Jens, Farde, Lars

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Identification of Cytochrome P450 Isoforms Involved in the Metabolism of Paroxetine and Estimation of Their Importance for Human Paroxetine Metabolism Using a Population-Based Simulator by JORNIL, Jakob, JENSEN, Klaus Gjervig, LARSEN, Frank, LINNET, Kristian

“…We identify here for the first time the low-affinity cytochrome P450 (P450) isoforms that metabolize paroxetine, using cDNA-expressed human P450s measuring…”
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N°356 - Muscle velocity recovery cycles as pharmacodynamic biomarker in a first-in-human trial of a first-in-class chloride channel 1 inhibitor: A randomized, double-blind, placebo-controlled, cross-over study in healthy subjects and patients with myasthenia grav by de Cuba, Catherine, Heuberger, Jules, Ruijs, Titia, Hutchison, John, Bold, Jan, Skjærlund Grønnebæk, Thomas, Gjervig Jensen, Klaus, Chin, Eva, Quiroz, Jorge, de Kam, Marieke, Koopmans, Ingrid, de Goede, Annika, Holm Pedersen, Thomas, Jan Groeneveld, Geert

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Lack of Exposure in a First-in-Man Study Due to Aldehyde Oxidase Metabolism: Investigated by Use of 14 C-microdose, Humanized Mice, Monkey Pharmacokinetics, and In Vitro Methods by Jensen, Klaus Gjervig, Jacobsen, Anne-Marie, Bundgaard, Christoffer, Nilausen, Dorrit Østergaard, Thale, Zia, Chandrasena, Gamini, Jørgensen, Martin

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Lack of Exposure in a First-in-Man Study Due to Aldehyde Oxidase Metabolism: Investigated by Use of super(14) C-microdose, Humanized Mice, Monkey Pharmacokinetics, and In Vitro Methods by Jensen, Klaus Gjervig, Jacobsen, Anne-Marie, Bundgaard, Christoffer, Nilausen, Dorrit Ostergaard, Thale, Zia, Chandrasena, Gamini, Jorgensen, Martin

“…Inclusion of a microdose of super(14) C-labeled drug in the first-in-man study of new investigational drugs and subsequent analysis by accelerator mass…”
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Metabolites of [14C]-5-(2-Ethyl-2H-tetrazol-5-yl)-1-methyl-1,2,3,6-tetrahydropyridine in Mice, Rats, Dogs, and Humans by CHRISTENSEN, E. B, ANDERSEN, J. B, PEDERSEN, H, JENSEN, K. G, DALGAARD, L

“…The M1 muscarine agonist, 5-(2-ethyl-2 H -tetrazol-5-yl)-1-methyl-1,2,3,6-tetrahydropyridine (Lu 25–109), is extensively metabolized in mice, rats, dogs, and…”
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Effects of organotin compounds on mitosis, spindle structure, toxicity and in vitro microtubule assembly by Jensen, K G, Onfelt, A, Wallin, M, Lidums, V, Andersen, O

“…Di- and tri-methyl, -butyl and phenyl tin, all as chlorides were tested for toxicity and spindle disturbances in V79 Chinese hamster cells and for effects on…”
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Lack of Exposure in a First-in-Man Study Due to Aldehyde Oxidase Metabolism: Investigated by Use of 14C-microdose, Humanized Mice, Monkey Pharmacokinetics, and In Vitro Methods by Jensen, Klaus Gjervig, Jacobsen, Anne-Marie, Bundgaard, Christoffer, Nilausen, Dorrit Østergaard, Thale, Zia, Chandrasena, Gamini, Jørgensen, Martin

“…Inclusion of a microdose of C-labeled drug in the first-in-man study of new investigational drugs and subsequent analysis by accelerator mass spectrometry has…”
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Differential effects of γ-secretase and BACE1 inhibition on brain Aβ levels in vitro and in vivo by Elvang, Anders Brandt, Volbracht, Christiane, Pedersen, Lars Østergaard, Jensen, Klaus Gjervig, Karlsson, Jens-Jakob, Larsen, Stine Anna, Mørk, Arne, Stensbøl, Tine Bryan, Bastlund, Jesper Frank

“…Alzheimer's disease (AD) is hypothesized to result from elevated brain levels of β-amyloid peptide (Aβ) which is the main component of plaques found in AD…”
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Differential effects of [gamma]-secretase and BACE1 inhibition on brain A[beta] levels in vitro and in vivo by Elvang, Anders Brandt, Volbracht, Christiane, Pedersen, Lars Østergaard, Jensen, Klaus Gjervig, Karlsson, Jens-Jakob, Larsen, Stine Anna, Mørk, Arne, Stensbøl, Tine Bryan, Bastlund, Jesper Frank

“…Alzheimer's disease (AD) is hypothesized to result from elevated brain levels of [beta]-amyloid peptide (A[beta]) which is the main component of plaques found…”
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Organotin compounds induce aneuploidy in human peripheral lymphocytes in vitro by Jensen, K G, Andersen, O, Rønne, M

“…In vitro exposure of PHA-stimulated human lymphocytes to organotin compounds resulted in statistically significant increases in the frequencies of hyperdiploid…”
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Differential effects of gamma-secretase and BACE1 inhibition on brain Abeta levels in vitro and in vivo by Elvang, Anders Brandt, Volbracht, Christiane, Pedersen, Lars Østergaard, Jensen, Klaus Gjervig, Karlsson, Jens-Jakob, Larsen, Stine Anna, Mørk, Arne, Stensbøl, Tine Bryan, Bastlund, Jesper Frank

“…Alzheimer's disease (AD) is hypothesized to result from elevated brain levels of beta-amyloid peptide (Abeta) which is the main component of plaques found in…”
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New alpha(1)-adrenoceptor antagonists derived from the antipsychotic sertindole - carbon-11 labelling and pet examination of brain uptake in the cynomolgus monkey by Balle, Thomas, Halldin, Christer, Andersen, Linus, Hjorth Alifrangis, Lene, Badolo, Lassina, Gjervig Jensen, Klaus, Chou, Yuan-Wha, Andersen, Kim, Perregaard, Jens, Farde, Lars

“…Central alpha(1)-adrenergic receptors are potential targets for recently developed antipsychotic drugs. Two new 11C labeled potent and selective…”
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In vitro metabolism of the M1-muscarinic agonist 5-(2-ethyl-2H-tetrazol-5-yl)-1-methyl-1,2,3,6-tetrahydropyridine by human hepatic cytochromes P-450 determined at pH 7.4 and 8.5 by Jensen, K G, Dalgaard, L

“…Biotransformation of the M1-muscarinic agonist Lu 25-109 (5-(2-ethyl-2H-tetrazol-5-yl)-1-methyl-1,2,3,6-tetrahydropyridine) , in development for the treatment…”
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