Search Results - "Jensen, Holly A"

6-Formylindolo(3,2-b)Carbazole (FICZ) Modulates the Signalsome Responsible for RA-Induced Differentiation of HL-60 Myeloblastic Leukemia Cells by Bunaciu, Rodica P, Jensen, Holly A, MacDonald, Robert J, LaTocha, Dorian H, Varner, Jeffrey D, Yen, Andrew

“…6-Formylindolo(3,2-b)carbazole (FICZ) is a photoproduct of tryptophan and an endogenous high affinity ligand for aryl hydrocarbon receptor (AhR). It was…”
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Retinoic acid therapy resistance progresses from unilineage to bilineage in HL-60 leukemic blasts by Jensen, Holly A, Bunaciu, Rodica P, Ibabao, Christopher N, Myers, Rebecca, Varner, Jeffrey D, Yen, Andrew

“…Emergent resistance can be progressive and driven by global signaling aberrations. All-trans retinoic acid (RA) is the standard therapeutic agent for acute…”
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The Src-family kinase inhibitor PP2 rescues inducible differentiation events in emergent retinoic acid-resistant myeloblastic leukemia cells by Jensen, Holly A, Styskal, Lauren E, Tasseff, Ryan, Bunaciu, Rodica P, Congleton, Johanna, Varner, Jeffrey D, Yen, Andrew

“…Retinoic acid is an embryonic morphogen and dietary factor that demonstrates chemotherapeutic efficacy in inducing maturation in leukemia cells. Using HL60…”
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iCoreDrop: A robust immune monitoring spectral cytometry assay with six open channels for biomarker flexibility by Jensen, Holly A., Kim, Jeong

“…Recent advances in spectral cytometry have extended our ability to monitor immune cell subsets and activation status while simultaneously improving rare…”
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Analytical performance of a 25‐marker spectral cytometry immune monitoring assay in peripheral blood by Jensen, Holly A., Wnek, Richard

“…Herein, we describe the development and analytical performance characteristics of a spectral flow cytometry assay for longitudinal immune monitoring biomarker…”
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Induced myelomonocytic differentiation in leukemia cells is accompanied by noncanonical transcription factor expression by Jensen, Holly A., Yourish, Harmony B., Bunaciu, Rodica P., Varner, Jeffrey D., Yen, Andrew

“…•We surveyed common myeloid leukemia cell lines undergoing differentiation therapy.•Lineage progression in induced leukemia cell lines differs from…”
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An Effective Model of the Retinoic Acid Induced HL-60 Differentiation Program by Tasseff, Ryan, Jensen, Holly A., Congleton, Johanna, Dai, David, Rogers, Katharine V., Sagar, Adithya, Bunaciu, Rodica P., Yen, Andrew, Varner, Jeffrey D.

“…In this study, we present an effective model All-Trans Retinoic Acid (ATRA)-induced differentiation of HL-60 cells. The model describes reinforcing feedback…”
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GW5074 and PP2 kinase inhibitors implicate nontraditional c-Raf and Lyn function as drivers of retinoic acid-induced maturation by Jensen, Holly A., Bunaciu, Rodica P., Varner, Jeffrey D., Yen, Andrew

“…The multivariate nature of cancer necessitates multi-targeted therapy, and kinase inhibitors account for a vast majority of approved cancer therapeutics. While…”
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Retinoic acid and 6-formylindolo(3,2-b)carbazole (FICZ) combination therapy reveals putative targets for enhancing response in non-APL AML by Bunaciu, Rodica P., MacDonald, Robert J., Jensen, Holly A., Gao, Feng, Wang, Xin, Johnson, Lynn, Varner, Jeffrey D., Yen, Andrew

“…In non-acute promyelotic leukemia (APL)- non myelocytic leukemia (AML), identification of a signaling signature would predict potentially actionable targets to…”
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Interferon regulatory factor-1 binds c-Cbl, enhances mitogen activated protein kinase signaling and promotes retinoic acid-induced differentiation of HL-60 human myelo-monoblastic leukemia cells by Shen, Miaoqing, Bunaciu, Rodica P., Congleton, Johanna, Jensen, Holly A., Sayam, Lavanya G., Varner, Jeffrey D., Yen, Andrew

“…Abstract All-trans retinoic acid (RA) and interferons (IFNs) have efficacy in treating certain leukemias and lymphomas, respectively, motivating interest in…”
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6-Formylindolo Modulates the Signalsome Responsible for RA-Induced Differentiation of HL-60 Myeloblastic Leukemia Cells by Bunaciu, Rodica P, Jensen, Holly A, MacDonald, Robert J, LaTocha, Dorian H, Varner, Jeffrey D, Yen, Andrew

“…6-Formylindolo(3,2-b)carbazole (FICZ) is a photoproduct of tryptophan and an endogenous high affinity ligand for aryl hydrocarbon receptor (AhR). It was…”
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6-Formylindolo by Bunaciu, Rodica P, Jensen, Holly A, MacDonald, Robert J, LaTocha, Dorian H, Varner, Jeffrey D, Yen, Andrew

“…6-Formylindolo(3,2-b)carbazole (FICZ) is a photoproduct of tryptophan and an endogenous high affinity ligand for aryl hydrocarbon receptor (AhR). It was…”
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Overcoming the differentiation block: Mechanisms of retinoic acid-induced differentiation, resistance, and lineage selection in myeloid leukemia progenitor cells by Jensen, Holly A

“…Differentiation induction therapy aims to “reform, rather than retaliate” like conventional chemotherapeutic methods. The most successful differentiation…”
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6-Formylindolo(3,2-b)Carbazole (FICZ) Modulates the Signalsome Responsible for RA-Induced Differentiation of HL-60 Myeloblastic Leukemia Cells: e0135668 by Bunaciu, Rodica P, Jensen, Holly A, MacDonald, Robert J, LaTocha, Dorian H, Varner, Jeffrey D, Yen, Andrew

“…6-Formylindolo(3,2-b)carbazole (FICZ) is a photoproduct of tryptophan and an endogenous high affinity ligand for aryl hydrocarbon receptor (AhR). It was…”
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The Src-Family Kinase Inhibitor PP2 Rescues Inducible Differentiation Events in Emergent Retinoic Acid-Resistant Myeloblastic Leukemia Cells. e58621 by Jensen, Holly A, Styskal, Lauren E, Tasseff, Ryan, Bunaciu, Rodica P, Congleton, Johanna, Varner, Jeffrey D, Yen, Andrew

“…Retinoic acid is an embryonic morphogen and dietary factor that demonstrates chemotherapeutic efficacy in inducing maturation in leukemia cells. Using HL60…”
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