Solitary Expression of CD7 Among T-Cell Antigens in Acute Myeloid Leukemia: Identification of a Group of Patients With Similar T-Cell Receptor β and δ Rearrangements and Course of Disease Suggestive of Poor Prognosis

In a series of 100 acute myeloid leukemia (AML) patients defined by cytochemistry and immunophenotyping, 20 expressed T-lymphocyte associated antigens on the surface of their blasts. While 15 expressed two or more T-cell antigens, five were found to express only CD7. All patients belonged to the Fre...

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Bibliographic Details
Published in:	Blood Vol. 78; no. 5; pp. 1292 - 1300
Main Authors:	Jensen, Arne W., Hokland, Marianne, Jorgensen, Hanne, Justesen, Just, Ellegaard, Jorgen, Hokland, Peter
Format:	Journal Article
Language:	English
Published:	Washington, DC Elsevier Inc 01-09-1991 The Americain Society of Hematology
Subjects:	Acute Disease Antigens, CD - biosynthesis Antigens, CD - genetics Antigens, CD - immunology Antigens, CD7 Antigens, Differentiation, T-Lymphocyte - biosynthesis Antigens, Differentiation, T-Lymphocyte - genetics Antigens, Differentiation, T-Lymphocyte - immunology Biological and medical sciences Gene Rearrangement, beta-Chain T-Cell Antigen Receptor - immunology Gene Rearrangement, gamma-Chain T-Cell Antigen Receptor - immunology Gene Rearrangement, T-Lymphocyte - immunology Hematologic and hematopoietic diseases Humans Immunophenotyping Leukemia, Myeloid - genetics Leukemia, Myeloid - immunology Medical sciences Remission Induction Antigen Human Correlation Prognosis Chronic myelocytic leukemia T-Lymphocyte Evolution Malignant hemopathy Gene expression Cell surface Acute myelocytic leukemia Biological receptor
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Summary:	In a series of 100 acute myeloid leukemia (AML) patients defined by cytochemistry and immunophenotyping, 20 expressed T-lymphocyte associated antigens on the surface of their blasts. While 15 expressed two or more T-cell antigens, five were found to express only CD7. All patients belonged to the French-American-British type M4, and four were under the age of 40. Despite intensive chemotherapy, four never obtained a complete remission and the fifth died of relapse after an allogenic bone marrow transplantation. While 12 randomly selected T-cell antigen negative AML patients showed only few rearrangements in Igor T-cell receptor (TCR) genes, such genetic alterations were demonstrated in four of five patients for the TCR δ gene and in all patients for the TCR β gene. Interestingly, DNA fragments of similar size were demonstrated in three of five patients for both the β and δ genes. These data suggest that the solitary presence of CD7 among T-cell antigens in otherwise clearcut AML cases identifies a group of patients with similarities in antigen receptor gene configuration as well as outcome.
Bibliography:	ObjectType-Article-2 SourceType-Scholarly Journals-1 ObjectType-Feature-1 content type line 23 ObjectType-Article-1 ObjectType-Feature-2
ISSN:	0006-4971 1528-0020
DOI:	10.1182/blood.V78.5.1292.1292