Search Results - "Jenquin, Jana R."

Mitigating RNA Toxicity in Myotonic Dystrophy using Small Molecules by Reddy, Kaalak, Jenquin, Jana R, Cleary, John D, Berglund, J Andrew

“…This review, one in a series on myotonic dystrophy (DM), is focused on the development and potential use of small molecules as therapeutics for DM. The complex…”
Get full text

A CTG repeat-selective chemical screen identifies microtubule inhibitors as selective modulators of toxic CUG RNA levels by Reddy, Kaalak, Jenquin, Jana R., McConnell, Ona L., Cleary, John D., Richardson, Jared I., Pinto, Belinda S., Haerle, Maja C., Delgado, Elizabeth, Planco, Lori, Nakamori, Masayuki, Wang, Eric T., Berglund, J. Andrew

“…A CTG repeat expansion in the DMPK gene is the causative mutation of myotonic dystrophy type 1 (DM1). Transcription of the expanded CTG repeat produces toxic…”
Get full text

Combination Treatment of Erythromycin and Furamidine Provides Additive and Synergistic Rescue of Mis-splicing in Myotonic Dystrophy Type 1 Models by Jenquin, Jana R, Yang, Hongfen, Huigens III, Robert W, Nakamori, Masayuki, Berglund, J. Andrew

“…Myotonic dystrophy type 1 (DM1) is a multisystemic disease that presents with clinical symptoms including myotonia, cardiac dysfunction, and cognitive…”
Get full text

Molecular characterization of myotonic dystrophy fibroblast cell lines for use in small molecule screening by Jenquin, Jana R., O’Brien, Alana P., Poukalov, Kiril, Lu, Yidan, Frias, Jesus A., Shorrock, Hannah K., Richardson, Jared I., Mazdiyasni, Hormoz, Yang, Hongfen, Huigens, Robert W., Boykin, David, Ranum, Laura P.W., Cleary, John Douglas, Wang, Eric T., Berglund, J. Andrew

“…Myotonic dystrophy type 1 (DM1) and type 2 (DM2) are common forms of adult onset muscular dystrophy. Pathogenesis in both diseases is largely driven by…”
Get full text

Furamidine Rescues Myotonic Dystrophy Type I Associated Mis-Splicing through Multiple Mechanisms by Jenquin, Jana R, Coonrod, Leslie A, Silverglate, Quinn A, Pellitier, Natalie A, Hale, Melissa A, Xia, Guangbin, Nakamori, Masayuki, Berglund, J. Andrew

“…Myotonic dystrophy type 1 (DM1) is an autosomal dominant, CTG•CAG microsatellite expansion disease. Expanded CUG repeat RNA sequester the muscleblind-like…”
Get full text

Small Molecule Approaches to Reduce the Effects of Toxic Repeat RNA in Myotonic Dystrophy Models by Jenquin, Jana R

“…Myotonic dystrophy type 1 (DM1) is an autosomal dominant, microsatellite expansion disease that presents with clinical symptoms including myotonia, cardiac…”
Get full text